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D Milovanović

Publications and source records attributed to D Milovanović.

At least 19 recordsLinked to original sources
PubMed1999

The effects of excitatory amino acids on isolated gut segments of the rat.

Glutamate and aspartate are excitatory neurotransmitters in both central and peripheral nervous systems, acting on ionotropic and metabotropic receptors. In our study we have examined the effects of glutamate, aspartate, N-methyl-d-aspartate (NMDA), kainic acid and (+/-)-1-aminocyclopentane-cis-1,3-dicarboxylic acid (ACPD) on tone and spontaneous activity of isolated rat gastric fundus, jejunum, ileum, ascending colon and rectum. Both glutamate and aspartate produced concentration-dependent tonic contractions of rat fundus and rectum; the other gut segments used in the study were not responsive. While only NMDA and kainic acid produced concentration-dependent tonic contractions of isolated rat gastric fundus, all three type-selective agonists of glutamate receptors (NMDA, kainic acid and ACPD) produced tonic contractions of isolated rat rectum. The results of our study suggest that glutamate and aspartate in rat gastric fundus activate excitatory intrinsic neurons through only ionotropic receptors (NMDA and non-NMDA receptors), while the same action in rat rectum is mediated through both ionotropic and metabotropic receptors.

Animals↗
PubMed1996

[Dopamine receptor subtypes].

Dopamine is a neurotransmitter in both central and peripheral nervous system. In the central nervous system dopamine is involved in regulation of: movements, emotional processing of sensory input, appetite, vomiting and secretion of anterior pituitary hormones. The most important peripheral effect of dopamine is control of splanchnic and renal blood flows. There are five subtypes of dopamine receptors. D1 receptors are responsible for majority of peripheral dopamine effects; in the brain they modulate activity of limbic system. Symptoms of schizophrenia are produced by increased activation of D2 and D4 receptors. On the other hand, Parkinson's syndrome could be induced by D2 receptors blockade. D3 receptors decrease craving in drug-dependent laboratory animals. Although D5 receptors were found in many brain regions and in peripheral blood lymphocytes, their functions remain unknown. Linking dopamine receptor subtypes with actual effects of dopamine will enable more selective therapy of disorders caused by malfunction of this important system.

Animals↗
PubMed1992

Aggressive inflammatory pseudotumor of the abdomen 9 years after therapy for Wilms tumor. A complication, coincidence, or association?

BACKGROUND: Inflammatory pseudotumor (IPT) is a benign lesion that occurs in various organs and tissues. It is usually sharply demarcated from the surrounding tissue and surgery is considered to be the best treatment. METHODS: This article discusses a 15-year-old boy with an aggressive IPT of the abdomen occurring 9 years after therapy for Wilms tumor. RESULTS: IPT widely involved the esophagus, stomach, and liver, producing severe dysphagia. Histologically, it showed classic features of IPT and, also, areas of metaplastic bone, a new feature recently described in the same lesion of the kidney. It mimicked malignant tumor clinically and led to extensive surgery, but early follow-up has shown no recurrence. CONCLUSION: Although many complications of surgery and chemotherapy are well known, the authors believe that it is unlikely to be the cause of IPT in the case presented. Therefore, the possibility of coincidence or association of Wilms tumor and IPT remains open.

Adolescent↗
PubMed1976

[Endometriosis of the ileum].

The following is an account of a case of Endometriosis of the Ileum in an 11 year old girl. The patient's first menstruation was accompanied by pain localized in the lower right abdominal quadrant. Her second menstruation was again accompanied by pain. During an explorative laparotomy, a tumorous mass was found in the wall of the ileum 50--60 cm proximal to Valvula Ileocecalis. The tumor was seven mm in diameter, having a fibrous thickening in the surrounding wall. A resection of this segment of intensine was performed. Histological findings confirmed an endometriosis of the Ileum of a polypoidal infiltrative type. The patient encountered no difficulties postoperatively. Proceeding menstruations were painless, which is indicative of an isolated endometriosis of the ileum.

Child↗