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D Mirković

Publications and source records attributed to D Mirković.

At least 19 recordsLinked to original sources
PubMed2001

Opposite effects of dexamethasone and ACTH on the adrenal cortex response to ethane dimethanesulphonate (EDS).

Recently we have reported that ethane dimethane-sulphonate (EDS), the Leydig cell cytotoxin, caused marked atrophy of the adrenal cortex of adult male rats. The aim of this work was to examine whether a 9-day treatment with dexamethasone (0.25 mg/kg/d) or ACTH (40 IU/kg/d), which started 4 days prior to administration of a single dose of EDS (75 mg/kg), influenced the response of the inner adrenocortical zones to the toxin. On day 15 after administration of EDS, adrenal weight was significantly decreased in saline treated rats, but glandular and serum corticosterone levels were not altered. In dexamethasone-suppressed rats, the effect of EDS was augmented; an additional decrease in adrenal weight was accompanied by reduced adrenal and serum corticosterone levels. In ACTH-treated animals EDS was ineffective. These results demonstrate that the deleterious effects of EDS on rat adrenal cortex can be prevented by ACTH and potentiated by dexamethasone.

Adrenal Cortex↗
PubMed1999

Plasma and urinary serotonin and 5-hydroxyindol-3-acetic acid in adults with migraine and tension-type headache.

Each headache can be a complex diagnostic, therapeutic, prognostic and social problem. The pain in the head can be connected with many organic and non-organic causes. In this work, the levels of plasma and urinary free 5-HT and 5-HIAA were investigated in eight migraine (aged 23-59 years) and ten tension-type headache suffers (aged 38-61 years). Based on the data obtained and their correlation with clinical features and in comparison with a control group, the following can be stated: (1) there is involvement of serotonin in migraine and tension-type headache during the attacks, although the positive 5-HT values from plasma were small; (2) urinary 5-HT values in migraine and tension-type headache were normal in comparison to the control group; (3) significantly decreased values of 5-HIAA in urine were found both in migraine and tension-type headache groups. These findings show that catabolism of 5-HT is probably decreased during headache periods; (4) visual aura was found in five out of ten subjects with tension-type headache.

Adult↗
PubMed1999

Plasma and urinary serotonin and 5-HIAA in children treated with lamotrigine for intractable epilepsy.

Alteration of monoamine levels by some antiepileptic drugs (AEDs) was elucidated in this study. Lamotrigine (LTG) is a new AED, acting the sodium-channels. LTG was given as add-on therapy to 16 patients aged 4.5-18 yrs with intractable epilepsy and comedicated with carbamazepine or valproate. An equal group of epileptics with comparable clinical characteristics and treatment served as control. Plasma and urinary (24 h-samples) serotonin and 5-HIAA were determined before onset of LTG therapy and after 2-3 months. HPLC and electrochemical detection was used for the determination of serotonin (5-HT) and 5-hydroxy indoleacetic acid (5-HIAA). No significant effect of LTG on both urinary 5-HT and 5-HIAA levels was found, whereas plasma 5-HT concentrations significantly decreased in comparison with levels before LTG starting and relevant values in controls. This findings was noted in 7/16 children with favourable response to LTG. Increased serotonin catabolism may be result of LTG action.

Adolescent↗
PubMedDate not supplied

The role of phospholipase A2 in the pathogenesis of respiratory damage in hemorrhagic necrotizing pancreatitis--assessment of a new experimental model.

The new experimental model has been set as a standard with the purpose to explore and analyze the role of phospholipase A2 in predicting the severity of acute pancreatitis with specific interest for the onset of hemorrhagic necrotizing pancreatitis and pleuropulmonary complications. The experiments were performed on dogs (n = 25), and acute pancreatitis was induced with the injection of 10% sodium-taurocholate into pancreatic duct. Four experimental groups of animals were formed, so that 2 groups had lymph held by draining the thoracic duct. In the other two groups, the lymph had been put into system circulation, so that the nylon bag was set around the pancreas in order to prevent pancreatic juice to be spilt into abdominal cavity. The analyses of the levels of amylase, lipase, pancreatic amylase and phospholipase A2 in of serum, lymph and exudate were performed. The positive correlation was found between increased concentration of phospholipase A2 in serum and reduction of partial pressure of oxygen and pH of blood and the degree of severity of respiratory failure. The speed and intensity of development of the acute hemorrhagic necrotizing pancreatitis, as well as the severity of pulmonary complications might be estimated upon the of increase of the levels of phospholipase A2 in serum and lymph. This experimental model enables the studying of pathogenesis of acute pancreatitis and systemic complications.

Amylases↗
PubMedDate not supplied

[Clinical evaluation of serum elastase-1 levels in patients with acute pancreatitis].

The prospective examination and quantitative determination of concentration of serum elastase 1 using RIA method were performed in 75 patients with pancreatic diseases at the Clinic of General and Vascular Surgery and the Institute of Nuclear Medicine of the M.M.A. in the period 1988-1989. The values of serum elastase 1 concentration were compared with values of amylase in serum and urine. The greater diagnostical importance of serum elastase 1 was found compared to values of amylase in serum and urine, not only in patients with acute pancreatitis but also in exacerbation of chronic pancreatitis. The level of serum elastase 1 concentration enables more reliable follow up of the evolution of the disease and therapeutical effects in patients with acute pancreatitis.

Acute Disease↗
PubMedDate not supplied

[Surgical treatment of toxic adenoma].

Sixty eight patients with toxic adenoma (TA) operated on in the period 1985-1992, were analyzed. The manifestation of hyperthyroidism in TA (in 55.88%) significantly depended on the gender of the patients (68.42% in men and 51.02% in women) and on the size of node. In nodes larger than 5 cm in diameter hyperthyroidism appeared in 76.92% of patients and in none with the nodes smaller than 2 cm. The degenerative changes in the nodes depended on pathohystological type of adenoma, and not on the size of nodes. On patohystological examination three carcinomas were found in TA, two papillary and one follicular. The surgical treatment of TA was the optimum way of treatment--the therapy of choice. Along with fast, complete and clear effects, the minimum percentage of complications (4.41%) developed that were mild and of short duration. The enucleation of nodes with capitonnage was absolutely sufficient in the operative treatment.

Adenoma↗
PubMedDate not supplied

[Surgical treatment of war injuries of the colon and rectum].

The results of retrospective analysis in the treatment of 155 wounded with colorectal lesions treated at the Military Medical Academy from July 1991 to December 1992 were presented. Primary surgical management was performed in 29 (18.7%) wounded and the others were transported into this hospital for further treatment after primary surgical management in war hospitals in the combat zone. Colorectal lesion (42.6%) were mostly inflicted by bullets of various caliber and high kinetic energy. Time interval between the wounding and surgery was less than 6 hours for 38.2% of wounded while 78.6% were operated within 12 hours. Multiple or combined colonic or rectal injuries were found in 91.6% of the wounded. Different surgical procedures were performed in accordance with the surgical war doctrine. Postoperative complications (colorectal cause) were found in 30 (19.3%) wounded. Reoperation was performed in 25 (16.1%) wounded and total mortality rate was 9.0% (14 wounded).

Colon↗