Biomedical subjects
Publications and source records attributed to D Misra.
Familial duodenal atresia occurs as part of Feingold syndrome. Other features of this variable autosomal dominant condition include tracheo-oesophageal fistula and oesophageal atresia, microcephaly, hand and foot anomalies, facial dysmorphism, and developmental delay. We report a father and two sons with Feingold syndrome. One has bilateral dysplastic kidneys which have not been reported previously.
A 33-year-old woman presented at 31 weeks' gestation with polyhydramnios that required repeated amniodrainage. An antenatal scan at 32 weeks showed dilated fetal bowel loops, which were not confirmed on subsequent scans. The amniotic fluid karyotype confirmed 47,XXX. After birth, jejunal obstruction was confirmed. To our knowledge, this is the first report of an association of triple-X syndrome and jejunal atresia.
Projectile deexcitation Lyman x-ray emission following electron capture and K excitation has been studied in collisions of bare and Li-like sulphur ions (of energy 110 MeV) with fullerenes (C(60)/C(70)) and different gaseous targets. The intensity ratios of different Lyman x-ray lines in collisions with fullerenes are found to be substantially lower than those for the gas targets, both for capture and excitation. This has been explained in terms of a model based on "solidlike" effect, namely, wakefield induced stark mixing of the excited states populated via electron capture or K excitation: a collective phenomenon of plasmon excitation in the fullerenes under the influence of heavy, highly charged ions.
Explore the source record for details and available documents.
Feeding jejunostomy is a recognized method of managing feeding difficulties and failure to thrive in neurologically impaired children. There are, however, significant associated complications. The authors report 4 cases of the potentially fatal complication of severe jejunoileitis, which has not been reported previously in children. The possible underlying mechanisms are discussed.
AIM: To investigate the safety of bronchoscopy and endobronchial biopsy in children with difficult asthma, and discuss the ethical issues associated with the procedure. METHODS: A three year prospective observational study was performed in two tertiary paediatric respiratory centres specialising in the management of children with difficult asthma. A total of 48 children with difficult asthma and 35 non-asthmatic children were studied. RESULTS: Flexible bronchoscopy was performed under general anaesthesia in 38 children with difficult asthma, and rigid bronchoscopy was performed in 10, following a two week course of prednisolone. Endobronchial biopsy was performed in 47 patients. Perioperative complications occurred in one asthmatic undergoing flexible bronchoscopy (desaturation) and in two undergoing rigid bronchoscopy (desaturation in one, and bronchospasm and desaturation in one). There were no cases of significant bleeding or pneumothorax among the asthmatics. Flexible bronchoscopy was performed in 35 non-asthmatic patients with a variety of clinical indications. The total number of perioperative complications was greater in the non-asthmatics undergoing flexible bronchoscopy than in the asthmatics (17 complications in 35 children versus one in 38). Fever requiring hospital admission was documented in two asthmatics following bronchoscopy. Four asthmatics reported an increase in symptoms in the week following bronchoscopy. CONCLUSIONS: Bronchoscopy and endobronchial biopsy under general anaesthesia can be performed safely in children with difficult asthma, when the bronchoscopist and anaesthetist are suitably trained. The procedure is acceptable to the families involved.
UNLABELLED: There are several contentious issues in the management of inguinal hernias in premature neonates. They include the timing of surgery, the management of incarceration, the role of routine contralateral groin exploration and the type of anaesthesia. In this article we re-emphasize the importance of delaying surgery until the baby is ready for discharge from the neonatal unit. Regular examinations and manual reduction of these hernias should be performed in order to detect incarcerations early. CONCLUSION: With this approach, it may be possible to minimize the morbidity resulting from incarceration, and at the same time avoid the respiratory and testicular complications resulting from an early surgical/anaesthetic intervention.
The presentation of two patients with the condition is described. The difficulty of finding an underlying cause of the infection is discussed, and the importance of a history of recent head and neck infection emphasised. Recommendations are made for appropriate antibiotic therapy to cover Staphylococci as well as the more common Streptococci.
The present study deals with the assessment of industrial water of an electronic component manufacturing unit with electroplating and its subsequent effects on soil and plants receiving the effluent. The physico-chemical parameters of the effluent samples showed higher value than that of ground water. The treated effluent was within the permissible limit. Microtox test was conducted and determined the degree of toxicity of untreated, treated effluents as well as the water sample collected at effluent discharge point of receiving river (confluence point). The physico- mechanical parameters of the soil samples were not changed due to irrigation of the treated effluent, but the concentration of metals were comparatively higher than the control soil. Higher accumulation of metals was found in the plant parts in naturally growing weeds and cultivated crop plant irrigated with treated effluent. Elevated accumulation of metals in Eichhornia crassipes and Marsilea sp. growing along the effluent channel has been identified as a potential source of biomonitoring of metals particularly for Cu and Ca and can be utilised for the removal of heavy metal from wastewater.
OBJECTIVE: To highlight the existence of Schistosoma haematobium in certain ethnic minority groups in Britain and in English citizens who have recently visited Africa and the Middle East, so that general practitioners and paediatric nephrologists/urologists are aware of its occurrence and consider it among the differential diagnoses in children presenting with haematuria. PATIENTS AND METHODS: Over a 2-year period, six consecutive boys (mean age 13.5 years, range 8-15) presented with haematuria and were subsequently diagnosed to be infected with S. haematobium. All patients were from Africa and had recently visited their native country. There had all reported paddling in freshwater lakes and streams. RESULTS: Dysuria and haematuria was noted 2-3 months after the infection. Terminal urine samples taken after exercise at midday were positive for S. haematobium ova. Praziquantel anti-schistosomal chemotherapy was effective in treating the infection. CONCLUSION: S. haematobium infection is treatable in the early stages and the changes are reversible before the development of fibrotic lesions, which may result in anatomical obstruction. A terminal urine sample taken at midday after exercise was diagnostic in showing Schistosoma ova in all cases. This infection must be considered in the differential diagnoses of haematuria in some ethnic minority British citizens and in those Britons who have visited Africa or the Middle East in the recent past.
Polymorphic ventricular tachycardia has been reported following the administration of adenosine for the treatment of SVT. We present a case of monomorphic ventricular tachycardia in a 75-year-old man following the intravenous administration of adenosine for stress testing.
OBJECTIVES: We examine the scope and nature of the recommendations that emerged from the Healthy Start Fetal and Infant Mortality Review (FIMR) projects and explore their use to promote systems change. METHODS: The FIMR process of 16 of the 22 federal Healthy Start projects was reviewed. We analyzed data from a June 1996 survey developed and administered by the MCH Bureau which gathered information about recommendations produced by the FIMRs. We supplemented these data with information gathered through follow-up telephone interviews and by abstracting information from grant documents. RESULTS: The 16 Healthy Start FIMRs reviewed approximately 1300 cases between 1991 and 1996. A total of 303 specific action strategies were recommended, reflecting eighteen specific substantive areas of concern. Overall, 65% of recommendations fell under the rubric of "program" functions, 31% under "practice," and 4% under "policy." Healthy Start itself was most commonly targeted for action. The second most frequent target for action were public and private provider institutions. Public policymaking entities were rarely targeted. CONCLUSIONS: In the first several years of implementation, with few exceptions these FIMRs sought limited change. They worked almost exclusively within their own span of control to effect important, but limited changes in systems serving women and their infants. As public health professionals seek to monitor population health, the field must strengthen any and all vehicles that draw upon collaborative structures at the community level to not only uncover problems, but to address them as well.
BACKGROUND: It is usually recommended that neonates with antenatally diagnosed hydronephrosis are put on prophylactic antibiotics and undergo the following investigations--ultrasound, MCU and a radio-isotope renogram. OBJECTIVE: To question the need for such an extensive protocol in antenatally diagnosed hydronephrosis on the basis of an improved understanding of this condition. METHODS: Over a 3-year-period, persistent postnatal hydronephrosis was seen in 42 neonates; in 12 it was bilateral. Antibiotic prophylaxis was stopped in the unilateral cases. An MCU was done mainly in the following circumstances: bilateral hydronephrosis, dilated ureter(s) or presence of UTI. A renogram was avoided if the AP diameter of the renal pelvis was below 15 mm and the calyces were not dilated. RESULTS: 1) The AP diameter of the pelvis was recorded in 40 renal units as follows--< 15 mm--22, 15-20 mm--10, 20-40 mm--6, > 40 mm--2. Both the patients in the latter group needed a pyeloplasty--their AP diameter exceeded 8 cms and an RNS showed depressed function. 2) In those patients who did not receive antibiotics or had a MCU, none has had a UTI. 3) Four unilateral hydronephrotic kidneys showed a paradoxical supranormal function, ranging from 54-60%. The contralateral kidney was completely normal on the RNS. CONCLUSION: 1) The vast majority of antenatally diagnosed hydronephrosis have a benign course, only 2/54 or 3.7% required a pyeloplasty. 2) Invasive investigations like an MCU are not necessary in most cases. 3) Routine antibiotic prophylaxis is not required in all unilateral cases and in bilateral ones after VUR has been excluded.
This retrospective study examines the size of the pyloric tumour at the time of surgery in 100 patients (76 boys, 24 girls) operated over a 2.75 years period from June 1993 to March 1996. The size of the pyloric tumour was classified into one of three categories (short, moderate or large) by the operating consultant and documented in the operation note. This study supports the view that the pyloric tumour increases in size with the progressing age of a baby. Nowadays the diagnosis of hypertrophic pyloric stenosis (HPS) is made on average 2 weeks earlier than in a similar study 4 decades ago. Two thirds of the patients in the subgroup with short- and moderate-size pyloric tumours did not require any imaging technique to arrive at the diagnosis. Unexpectedly a more frequent use of imaging techniques was required in the subgroup of large pyloric tumours; large tumours tend to present as an ill-defined fullness in the right upper quadrant rather than a distinct olive.
BACKGROUND: Despite much initial enthusiasm, umbilical pyloromyotomy has failed to achieve widespread popularity. This mostly relates to difficulty with delivering the pyloric tumour through the relatively small incision. METHOD: A new technique for umbilical pyloromyotomy is described in which a circumumbilical skin incision with a right lateral extension is combined with transverse division of the linea alba and part of the right rectus muscle. The pyloric tumour is easily delivered to the skin surface through this generous minilaparotomy. After muscle closure the lateral skin extension is swung medially as described and incorporated within the umbilical scar. RESULTS: We report our experience of 30 cases in which this technique was successfully employed. The pyloromyotomy was done on the surface in all cases and the resulting scar was barely visible in the folds of the umbilicus.
Over the last 11 years, 101 patients of Wilms tumor were treated at our hospital. Of these, 7 had bilateral Wilms tumors (BWT). The first two patients were referred in terminal stages and died. Of the latter five, three have survived while one is on treatment. One patient succumbed to liver metastasis, he had stage III disease on one side and was irregular in his chemotherapy protocol. Remarkably, one of the survivors was cured even after developing vertebral metastasis, retroperitoneal recurrence and bilateral lung metastasis. Part of the success was due to "salvage chemotherapy regimens" using Cis-plantinum, ifosphamide and VP-16. Flow cytometric analysis of DNA ploidy performed on only three of the five patients showed that two tumors were aneuploid and one was diploid. Spectacular cure rates can be achieved in BWT by renal conservation surgeries and effective chemotherapy. The use of "salvage chemotherapeutic regimes" and the study of DNA ploidy is being highlighted.
OBJECTIVE: Our purpose was to compare the costs of prenatal care and subsequent maternal and neonatal outcomes in patients with gestational diabetes cared for in an inner-city university hospital house staff clinic versus an inner-city managed care organization. STUDY DESIGN: A retrospective cohort study was conducted. The groups consisted of 115 patients with gestational diabetes who were cared for in a house staff clinic and a demographically similar group of 85 patients cared for in a neighborhood managed care organization. The groups were examined regarding baseline demographics, intensity of prenatal care, maternal and neonatal outcomes, and total cost of the provision of care. RESULTS: There was no difference between groups in the total cost of maternal-infant care. A larger percentage of patients in the house staff group saw the physician frequently. In contrast, patients cared for in the managed care organization underwent more tests of fetal well-being. There was a greater rate of neonatal macrosomia in the managed care organization group compared with the house staff group. CONCLUSIONS: Managed care does not decrease the cost of caring for patients with gestational diabetes but does lead to a greater rate of neonatal macrosomia, which may reflect poorer glucose control.
OBJECTIVES: To evaluate the feasibility of using the scrotal approach in patients with undescended testes. METHODS: Over an 18-month period, 165 patients were diagnosed to have 208 undescended testes. Of these, 28 were nonpalpable. RESULTS: At exploration, 7 testes were abdominal, 33 were canalicular, 165 were in the region of the external ring/pubic tubercle, and 1 was perineal. There were 2 cases of unilateral monorchism. The operative procedure performed was as follows: orchiectomy for 6 abnormal testes, orchiopexy for 142, and scrotal fixation (SF) for 58. (In this series, 9 patients were converted from SF to an orchiopexy at the time of the initial operative procedure.) SF involves a scrotal incision extending down to the tunica vaginalus. The cord is then mobilized from below, after which the testis is placed in an extra-dartos pouch. CONCLUSIONS: Our study has shown that there are a significant number of undescended testes that lie in the region of the pubic tubercle, lack a hernial sac, and can be managed by a scrotal mobilization alone. Based on our experience with SF, we have used a simple classification of undescended testis that has therapeutic and prognostic justifications.