PubMed Health⌕ Search

Biomedical subjects

D Misra

Publications and source records attributed to D Misra.

At least 55 records · Page 3Linked to original sources
PubMed1991

Proxy respondents in reproductive research: a comparison of self- and partner-reported data.

The quality of proxy reporting was assessed among 136 prenatal patients and their spouse/partners recruited from the obstetric services of a New Jersey hospital between 1985 and 1987. The concordance, sensitivity, and specificity of proxy reports about partners' occupation, smoking, and drinking were examined in relation to self-reports. Overall, private patients provided better proxy data than did clinic patients, and women provided better data than did men. No consistent effects on the quality of proxy reports were found in relation to age, level of education, marital status, or length of cohabitation. Partners' recent job titles appeared to be quite accurately reported, whereas partners' smoking and drinking patterns were less well-reported. For alcohol use in particular, there was evidence of considerable misclassification resulting from proxy reports even when kappa statistics and intraclass correlation coefficients suggested good agreement. Use of proxy respondents is unnecessary in reproductive studies and should be avoided when it may produce misleading results. Our data indicate that private prenatal patients and their partners can give reasonable proxy reports about job titles and smoking, but not about alcohol use. The high proportion of clinic patients who did not refer a partner (or whose partners could not be contacted) limits the generalizability of our results for this group and gives cause for concern about collecting proxy information from clinic populations.

Adolescent↗
PubMed1989

Effect of post-hypoxic acclimatization on extremity temperature during exposure to acute cold stress in man.

Twelve male volunteers aged 20-28 yr, who were physically fit for high altitude duties were studied. Recordings of oral temperature, mean skin temperature, extremity temperature, O2 consumption and heart rate were taken in a thermoneutral room (26 degrees +/- 2 degrees C) and cold room (6 degrees-8 degrees C) initially; after 4 wk stay at 3353 m (502 mm Hg); again after 4 wk at 4115 m (455 mm Hg); and finally after return to Delhi (740 mm Hg). The oral temperature, mean skin temperature, oxygen consumption and heart rate did not show any significant difference from their initial sea level values recorded in the thermoneutral room or the cold room. It may be concluded that our subjects did not exhibit any degree cold acclimatization when retested at sea level. A significant elevation (P less than 0.001) of extremity temperature observed during retest in cold might be due to some degree of vasodilatation through relaxation of constrictor tone that might have taken place during exposure to hypoxia at high altitude.

Acclimatization↗
PubMed1988

Quinazolyl benzophenothiazines as potential antiviral agents.

The reaction of anthranilic acid with excess of benzoylchloride in the presence of pyridine yielded 2-phenyl(3H) 4-oxo-3,1-benzoxazine(I). Interaction of (I) with 2-aminoethanol afforded 2-phenyl-3-hydroxy-ethyl(3H) 4-oxo-quinazoline (II). The condensation of (II) with beta-naphthol in the presence of conc. H2SO4 gave 1-(2'-phenyl-3'-ethyl-4'-oxo-quinazolyl) beta-naphthol (III). The reaction of (III) with primary aromatic amines in the presence of anhydrous zinc-chloride afforded 1-(2'-phenyl-3'-ethyl-4'-oxo-quinazolyl)-beta-naphthyl phenyl amine (IV). When (IV) was heated with sulphur and iodine, 1-(2'-phenyl 3'-ethyl -4'-oxo-quinazolyl)-benzophenothiazine (V) was obtained. All the five synthesised benzophenothiazines were screened for their antiviral activity and two compounds exhibited significant inhibition of virus multiplications.

Animals↗
PubMed1982

Influence of sex hormones on parathion toxicity in rats: antiacetylcholinesterase activity of parathion and paraoxon in plasma, erythrocytes, and brain.

Administration of parathion resulted in a greater inhibition of acetylcholinesterase (AChE) activity of plasma, erythrocytes, and brain in female rats than in male rats. No sex-related difference was observed in the antiacetylcholinesterase activity of paraoxon, an active metabolite of parathion. Gonadectomy increased the susceptibility of males but had no perceptible effect on females, resulting in comparable inhibition of AChE by parathion in both sexes. Administration of testosterone led to recovery from increased sensitivity to the antiacetylcholinesterase activity of parathion in castrated males and afforded partial protection to ovariectomized females. On the other hand, administration of estradiol further enhanced the enzyme inhibition by parathion in castrated males but had no significant effect on that in ovariectomized females. Alterations in the status of sex hormones did not affect the antiacetylcholinesterase activity of paraoxon in plasma and erythrocytes. However, inhibition of AChE activity by paraoxon was significantly higher in brains of gonadectomized rats than those of normal rats and the effect was reversible on administration of the respective sex hormones. The results indicate that testosterone plays an important role in determining parathion toxicity (as reflected by its antiacetylcholinesterase activity), probably by activating the oxidative cleavage of the insecticide into nontoxic metabolites.

Animals↗
PubMed1982

Complete amino acid sequence of the ADP/ATP carrier from beef heart mitochondria.

The complete primary structure of the ADP/ATP carrier from beef heart mitochondria is described. Cyanogen bromide cleaves the protein into a long, N-terminally blocked fragment with Mr 22,000 (CB1) and several small peptides. The primary information was derived from liquid-phase sequencing of tryptic peptides obtained from the maleylated carrier protein and the citraconylated CB1 fragment, as well as from cleavage products with Staphylococcus aureus protease. The multitude of thermolysinolytic, tryptic, chymotryptic and peptic peptides was sequenced by manual methods. They rendered overlaps and further supported already known partial sequences. Also, the bridge between the published acidolytic C-terminal fragment A2 was thus obtained.

Amino Acid Sequence↗
PubMed1977

Contribution of lactic acid by the ampullary and isthmic parts of rabbit Fallopian tube under altered hormonal conditions.

The capability of the ampullary and isthmic parts of the rabbit Fallopian tube to contribute lactic acid (LA) to the tubal lumen was examined using an in vitro method of study. In addition concomitant study was also made using the uterus. It was found that in the oestrous rabbit, the isthmus contributed LA at a higher rate than that of the ampulla; the uterine contribution was minimal. Ovariectomy reduced while exogenous oestrogen enhanced this ability in all the three tissues. In mated post-ovulatory rabbits the contributory efficiency of either tubal part changed and appeared to exhibit a peak value in the presence of the ovum; the uterus showed no such changes. This is discussed in relation to the ability of the egg to secure its energy source until it attained morula/the pre-blastocyst stage.

Animals↗
PubMed1977

Erythrocytic glucose-6-phosphate dehydrogenase deficiency amongst non tribal population of Orissa.

Blood samples from three hundred subjects belonging to the non-tribal population of Orissa were examined for G-6-PD deficiency employing the methaemoglobin reduction test. G-6-PD deficiency was detected in 19 (6.3%) persons. Full expression was observed in 11 (3.6%) and partial expression in 8 (2.6%) individuals. Although a higher incidence in males was noted, this difference was not statistically significant. A brief review regarding prevalence of G-6-PD deficiency in various parts of the world and in other states of India is presented.

Female↗
PubMed1977

Incorporation of [U-C14-A1-glucose in vitro by different parts of the rabbit Fallopian tube and uterus.

The in vitro incorporation of E1U-C14]-glucose by ampullary and isthmic segments of the Fallopian tube and the uterus was determined in the intact (estrous), ovariectomized, ovariectomized plus estrogen and ovarietcomized plus estrogen + progesterone treated rabbit. In the intact animal the ampulla incorporated glucose at a faster rate than the isthmus; uterine uptake is minimal. Ovariectomy reduced the rate of incorporation below normal values in all the tissues. EDP (estradiol dipropionate) administered to ovariectomized rabbit increased the incorporation rate. Progesterone antagonized the EDP-induced uptake. The relative rate and pattern of incorporation by the three tissues were, however, determined by the dosage of estrogen and the estrogen/progesterone ratio.

Animals↗