PubMed Health⌕ Search

Biomedical subjects

D Modai

Publications and source records attributed to D Modai.

At least 109 records · Page 6Linked to original sources
PubMed1982

Zinc and copper levels in plasma, erythrocytes, and whole blood in cancer patients.

Zinc and copper levels in erythrocytes, plasma, and whole blood were determined in 35 cancer patients and compared with 24 normal individuals. A decrease in zinc was found in all three blood constituents of the cancer patients. The decrease was significant in plasma and whole blood and nonsignificant in erythrocytes. Copper levels in the cancer group showed a slight and nonsignificant increase in erythrocytes, plasma, and whole blood. The copper to zinc ratio revealed a significant increase only for plasma levels. Further investigations are indicated to determine whether these two elements could serve as indicators for diagnosis or prognosis in cancer patients.

Aged↗
PubMed1982

Legionnaires' disease in Israel: a serological study of hemodialysis patients.

A serological survey was performed in three Israeli hospitals in order to evaluate the risk of nosocomial spread of the agent of Legionnaires' Disease or antigenically related organisms. Five out of 79 chronic hemodialysis patients had titers (1:512 to 1:2,048) of indirect immunofluorescence antibodies considered indicative of past infection. None of 44 healthy subjects, 37 ambulatory patients or 16 patients with acute gram-negative sepsis due to unrelated organisms showed a seroreaction of greater than or equal to 1:128.

Adult↗
PubMed1981

Vitamin D resistant rickets with alopecia: a form of end organ resistance to 1,25 dihydroxy vitamin D.

A 4-year-old girl presented with severe clinical and radiological rickets, and alopecia since the age of 1 year. Laboratory studies revealed: hypocalcaemia, hypophosphataemia, secondary hyperparathyroidism, abnormally low intestinal calcium absorption, and markedly elevated circulating 1,25(OH)2D3 levels. A normal calcaemic response to parathyroid extract was obtained. Treatment attempts with vitamin D2, 1 alpha (OH)D3 and 1,25(OH)2D3 were totally ineffective. Intestinal resistance to the action of 1,25(OH)2D3 appeared well established in this case. Refractoriness of bone to this hormone seems less certain. From this new entity of 'Vitamin D resistant rickets due to end organ unresponsiveness', six cases have been hitherto reported in the literature. However, only two have enough resemblance to our case, to constitute a distinct and well defined nosologic subunit. The molecular basis of this disorder(s) remains to be elucidated.

Alopecia↗
PubMed1981

Eosinophilia in uremia.

Peripheral and bone marrow eosinophils were determined in a group of patients on chronic hemodialysis and in predialysis uremics. Healthy subjects were taken as controls. Increased number of eosinophils in bone marrow were found in the predialysis uremic group and this finding was even more accentuated in the dialyzed patients. Marrow eosinophilia correlated linearly with serum creatinine levels in the predialysis group. The peripheral eosinophil count was normal in the uremic group and in part of the hemodialysis group. Marked and progressive peripheral eosinophilia was evident in a distinct subgroup of the dialysis patients. Marrow eosinophilia seems to be part of the uremic syndrome. The possible nature of the factor(s) involved in the derangement of eosinophil homeostasis is discussed.

Adolescent↗
PubMed1981

Effect of uremic serum on E-rosette formation of normal lymphocytes modulated by levamisole.

The number of E-rosette forming cells of lymphocytes from healthy subjects was determined under various experimental conditions. Sera from 16 chronic hemodialysis patients were incubated with lymphocytes from 16 matched normal subjects. The effect of levamisole on this combination was studied. Uremic serum markedly inhibited E-rosette formation of normal lymphocytes. Pretreatment with levamisole completely prevented this effect, whereas levamisole treatment following incubation with uremic serum resulted in a partial correction of the E-rosette formation. The hypothesis best fitting these results is that a factor present in uremic serum blocks sheep red cell receptors on normal lymphocytes; levamisole, having a greater affinity for these receptors, prevents or partially corrects the effect of the blockade.

Humans↗
PubMed1980

Effect of levamisole on skin reactions to DNCB in chronically dialyzed patients.

The local cutaneous inflammatory response to DMCB sensitization was positive in only 35% of 20 uremic patients, and the delayed skin reaction was positive in only 15%. The reaction to DMCB challenge was markedly delayed in some patients. Improved response to DNCB re-challenge followed levamisole administration in only 16% of the patients and was not associated with a rise in blood lymphocytes.

Adolescent↗
PubMed1980

Metabolic effects of intravenous ritodrine infusion in pregnancy.

The effects of intravenous administration of Ritodrine on blood glucose, insulin, electrolytes, plasma and red cell potassium and venous pH were investigated. A highly significant increase in blood glucose and insulin occured. A highly significant negative correlation between serum and red cell potassium concentration was registered (r = -0.96268). No signficant changes during Ritodrine infusion were recorded in serum levels of sodium, chloride, calcium, phosphorus and magnesium. The pH did not seem to be influenced by intravenous Ritodrine administration. No cardiac arrhythmias or electrocardiographic deteriorations occurred. While intravenous Ritodrine administration seems to be safe in normal pregnancies, a risk may be present in diabetic and digitalized patients, and pregnant women being treated by diuretics.

Adult↗
PubMed1980

Controlled sodium bicarbonate infusion and maternal acid--base balance during labor.

The effects of a controlled sodium bicarbonate (S.B.) infusion on the acid-base balance of primiparas in normal labor and delivery were studied and compared to a similar control group of primiparas without S.B. infusion. Beginning at 6 cm cervical dilatation. 2mEq of S.B./kg of total body weight were infused to patients in the study until full cervical dilatation. The dosage given to this group emerged from a study of base deficit dynamics and space distribution of S.B. in a control group of patients during labor and delivery. Significant variations in pH, base excess, and plasma bicarbonate were observed, beginning 44 +/- 19 minutes after the S.B. infusion. These variations in acid-base parameters persisted for 10 minutes following delivery. While no adverse effects were observed in our patients, this experimental design represents a preliminary approach toward correcting deleterious fetal acid-base variations during labor and delivery.

Acid-Base Equilibrium↗
PubMed1979

Controlled intravenous bicarbonate and fetal-maternal acid-base balance. I. The primipara.

The effects of a controlled sodium bicarbonate (SB) infusion on the acid-base balance of the primiparous mother and fetus at labor and delivery were evaluated. Two identical groups of primiparas with normal labor and delivery were studied. According to acid-base parameters observed in the mothers and fetuses of a control group, the pharmacologic dynamics, and the space of distribution of SB, 2 mEq/1 kg of total body weight were administered to the mothers of the study group, beginning at a cervical dilation of 6 cm until full dilation occurred. Highly significant changes in pH, base excess (BE), and plasma bicarbonate were observed in both the mothers and fetuses. In the latter, the significant changes appeared after a time lag of about 2 hours. No adverse effects in the mothers and fetuses were observed. The significant reduction of the relative fetal acidosis by the controlled SB infusion justifies further studies on the therapy potentials of this method in high-risk deliveries and during intrapartum fetal distress.

Acid-Base Equilibrium↗