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Biomedical subjects

D Modersohn

Publications and source records attributed to D Modersohn.

54 records · Page 3Linked to original sources
PubMed1976

[Vetorial presentation of left-ventricular pressure parameters for the assessment of ventricular function].

The ventricle function can be established by the vectorial description of left-ventricular pressure parameters or flow sizes, respectively. The vector diagrammes result from the momentaneous pressure within the ventricle on the X-axis and the differentiated pressure curve or the aortic flow, respectively, on the Y-axis. Well surveyable from the vector loop received (LVP/dp/dt) are established dp/dtmax, dp/dtmin, LVPmax, LVEDP as well as the tg of the pressure increase speed or the pressure decrease speed, respectively, pro developed pressure. By way of example medicamentous changes of the vector diagrammes were induced and the parameters mentioned established. The vectorial demonstration of the left-ventricular haemodynamics seems to give additional informations concerning the phase of centraction and relaxation

Adrenergic beta-Antagonists↗
PubMed1976

[Electronic processing of intravascular by measured blood pressure].

With the help of electronic processing of measurement values the possible information content of the dynamic blood pressure measured by means of the electromanometer is explained. Commericial writing systems and pressure changers are supplemented by self-constructed and especially dimensioned additional devices. Partly in connection with flow sizes by multiplication, division, addition, subtraction, differentiation and integration from pressure values special references to the behaviour of the haemodynamics of certain parts of the circulation are to be obtained. This is explained by examples. In addition to this the authors deal with the systolic and diastolic indication of blood pressure important for haemodynamic measuring programs, with the electronic mean value formation, with the limitaor connection for the indication of the enddiastolic ventricular pressure as well with the short-term accumulation. The electronic processing of the intravasally measured blood pressure as well as of flow values is necessary for analyses of the circulation.

Blood Pressure↗
PubMed1975

[Problems in the use of cardiac glycosides in ischemic heart disease].

With the help of instances from literature and own experimental and clinical experiences is described that a schematic digitalisation in ischaemic heart diseases is not worth being advocated scientifically. Heart glycosides are indicated especially then, when a heart insufficiency stands in the foreground. In the acute phase of infarction, without manifest heart insufficiency, however, in individual cases they can deteriorate the myocardial oxygen balance and thus the clinical course. In myocardial infarction with severe heart insufficiency up to the cardiogenic shock all therapeutic possibilities should be utilized; to this belongs also the application of glycosides. As a rule in cardiogenic shock after myocardial infarction glycosides have no sufficient measurable influence on haemodynamics. Heart glycosides together with an individually adapted kinetotherapy are of importance for the metaphylaxis in patients with infarction.

Cardiac Glycosides↗
PubMed1975

[Influence of coronary-effective substances on the concentration of nonesterified fatty acids in the serum of patients with angina pectoris].

In a study of patients with angina pectoris the influence of coronary-effective medicaments on the concentration of non-esterified fatty acids was investigated. Supplementary establishments were carried out experimentally on pigs. Compared with normal persons patients with angina pectoris had a significantly higher level of non-esterified fatty acids. In an oral dose of 150 mg a day propranolol decreased the non-esterified fatty acids to normal values. Dipyridamol decreased the concentration of non-esterified fatty acids in the serum in an average dose of 450 mg a day also significantly. The combination of propranolol and dipyridamol did not evoke a particular additive effect on the decrease of non-esterified fatty acids. In a dosage of 300 mg a day orally trapymin had no clear influence on the non-esterified fatty acids. D,L-oxyfedrin (64 mg orally a day) increased the concentration of the non-esterified fatty acids in the serum. The decrease of the level of non-esterified fatty acids seems important for the prophylaxis of the infarction. The antilipolytic effect is a desirable therapeutic mechanism among others in the coronary therapy.

Angina Pectoris↗
PubMedDate not supplied

[Coronary reserve determination by intracoronary papaverine: effects of various doses on coronary circulation and hemodynamics].

In 40 male coronary patients during heart catheterization the coronary flow reserve was investigated by continuous thermodilution in the coronary sinus after intracoronary papaverine application. Simultaneously a number of heart function parameters were recorded. Already the lowest dosage of papaverine (5 mg) was able to induce a maximal flow acceleration. Higher dosages were accompanied with haemodynamic side effects (increase of heart rate and left ventricular end-diastolic pressure, decrease of left ventricular systolic pressure, appearance of myocardial ischemia) without further increase of coronary flow. After at most 5 minutes time the papaverine effects completely disappeared. In conclusion, a safe, short-lasting and repeatable determination of the coronary flow reserve (for instance during PTCA) proved to be possible after intracoronary papaverine injection in low dosages (5 mg).

Blood Flow Velocity↗