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Biomedical subjects

D Monova

Publications and source records attributed to D Monova.

14 recordsLinked to original sources
PubMed1991

[A clinico-therapeutic study of the Bulgarian preparation fupiram].

The study includes 30 patients: 21 patients with various cardiac diseases which had led to chronic cardiac failure with well expressed edemas, 7 patients with liver cirrhosis and ascites, 2 patients with chronic glomerulonephritis and nephrotic syndrome. For 7 consecutive days the patients received fupyram or furanthril. In the morning, before breakfast, they received either 1 capsule fupyram (which is composed of amyloride hydrochloride 0.005 g and furezemide 0.04 g) or 1 tablet furanthril. In case of insufficient diuresis the daily dose was increased to 2 capsules fupyram (or 2 tablets furanthril respectively). In the patients with satisfactory diuretic effect the dose was reduced to 1 capsule (tablet) every other day or 2 capsules 2 times weekly after the second week. At the end of the 4-th week the general condition of the patients improved considerably. The diuresis increased, the body mass and the arterial pressure decreased. The potassium serum level increased from 4.4 +/- 0.3 mmol/l at the beginning of the treatment to 5.3 +/- 0.7 mmol/l. In 11 patients the potassium level reached values about 5.5 mmol/l. The drug fupyram exerts a pronounced diuretic efficacy. In the patients with preserved renal function fupyram does not change significantly the potassium serum level, but in patients with impaired renal function it can lead to hyperkalemia even after an unprolonged treatment.

Aged↗
PubMed1991

[Gemfibrozil in the treatment of hyperlipoproteinemias].

30 patients with primary hyperlipoproteinemia (type II and IV according to Fredrickson) were treated with Gemfibrosil (Gevinon--film tablets of 450 mg of "Parke-Davis Company") for a period of 45 days with a daily dose of two tablets taken with the evening meal. The results of the treatment were a decrease of the total cholesterol (with 16.34%), of triglycerides (with 34.50%), of low density lipoproteins (with 10.76%) and of very low density lipoproteins (with 49.21%) and an increase of the high density lipoproteins (with 2.34%). Gevilon was well tolerated. No side effects requiring discontinuing of the treatment were registered.

Adult↗
PubMed1990

[Guanfacine in the treatment of arterial hypertension in diabetics].

30 patients with hypertension and diabetes mellitus type II were treated with guanfacine (Estulic--"Sandoz" Switzerland) 1 mg tablets in the course of 6 months. The trial began with a placebo period at the end of which the patients were classified into groups: I groups--mild hypertension--14 patients, II group--moderate hypertension--8 patients and III group--severe hypertension - 8 patients. The treatment began in all patients with 0.5 mg Estulic once a day in the evening. According to the effect the dose was increased in one week intervals to 1, 2 and 3 mg daily. A very good effect was achieved in 24 patients (80%), good effect--in 3 patients (10%). There was no effect in 3 patients (10%) with diastolic pressure at the end of the placebo period of 15.3 kP (115 mm Hg). The drug Estulic did not deteriorate the glucose tolerance and in 22 patients (73.3%) a decrease of the blood sugar levels with mean 3.47-1.98 mmol/l was found.

Adolescent↗
PubMed1990

[A case of xanthogranulomatous pyelonephritis].

A case of a 38 years old man with xanthogranulomatous pyelonephritis is presented. The ultrasound examination of the abdomen found a tumorous formation above the left kidney. Arterial hypertension and changes in the lipid metabolism were found clinically. The i. v. urography revealed more characteristic changes. The diagnosis xanthogranulomatous pyelonephritis is based on the computed tomography findings and the clinico-laboratory examinations.

Adult↗
PubMed1990

[Treatment of chronic glomerulonephritis with high doses of intravenous immunoglobulin].

The initial results of the treatment of 8 patients with idiopathic and lupus glomerulonephritis with immunovenin intact are reported. Previously the patients had been treated for a long time with combinations of corticosteroids, immunosuppressors and anticoagulants without effect. All patients had an well expressed nephrotic syndrome, 6 patients had initial chronic renal failure. The immunovenin intact treatment was carried out in three day courses of 85 mg/kg/24 h (a total of 250 mg/kg for one course). All patients received two courses of treatment. The patients were followed up for 3 to 30 months (mean 10.0 +/- 3.29). In 4 patients a full clinical remission was achieved. Two patients, after a satisfactory effect of the treatment, died from non-renal causes. The mechanisms of action of immunovenin intact are discussed.

Azathioprine↗
PubMed1989

[Ciprofloxacin in bacterial infections].

42 patients with bacterial infections caused by resistant to other available in this country antibiotics, immunocompromised patients and patients in severe life-threatening conditions were treated with ciprofloxacin (Ciprobay--Bayer) in tablets. Before being admitted to the clinic most of the patients had been treated with various antibacterial drugs, including Tarivid--Hoechst (4 patients), in sufficient doses and duration. The drug was applied in doses of 250 mg or 500 mg twice daily according to the type, site, severity of the infection and the renal function state. The treatment continued for 5 up to 10 days. The results were judged by a three degree scale. In 37 patients (88.1%) the results were considered very good and in 5 patients (11.9%)--good. The side effects were insignificant. Ciprofloxacin emerges as a strong antibacterial drug with a very good therapeutic efficacy in patients with severe infections of the urinary tract and other organs.

Adult↗
PubMed1989

[Captopril from Pharmachem in the treatment of arterial hypertension].

30 hypertensive patients were treated in outpatients conditions for a 6 month period with captopril "Pharmachem". The patients were classified in accordance with the degree of the arterial hypertension into three groups: light hypertension--II patients, moderate hypertension 13 patients and severe hypertension--6 patients. Captopril was applied the first two weeks in a dose of 25 mg 3 times daily. When there was no effect the dose was increased every two weeks with 25 mg daily up to a 150 mg daily dose. A very good result was achieved in 11 patients (36.7%) and in 15 patients (50%) the result was considered good. In 4 patients the arterial pressure fell to normal after the addition of chlorthalidone. The following side effects were observed: decrease of the leucocyte number in reference ranges, insignificant increase of the uric acid in reference ranges, proteinuria below 1 gr/24 h. Captopril "Pharmachem" applied alone or in combination with a diuretic is a very efficient drug for the treatment of all stages of arterial hypertension.

Adult↗
PubMed1988

[Rapidly progressing glomerulonephritis developing against a background of idiopathic nephrotic syndrome].

A case is presented of a woman with idiopathic nephrotic syndrome--mesangioproliferative glomerulonephritis who after a 7-year therapeutic remission developed a rapidly progressing (semilunar) glomerulonephritis with a severe nephrotic syndrome, arterial hypertension, anemia, renal failure. The patient was not influenced by the treatment with ordinary doses of glucocorticosteroids and temporarily improved by the combined "pulse" methylprednisolone, immunosuppressive and heparin treatment. The possible pathogenetic mechanisms which may have played a role in the transition of the idiopathic nephrotic syndrome into a rapidly progressing glomerulonephritis are discussed.

Adolescent↗
PubMed1987

[Nifedipine in the treatment of arterial hypertension].

The results are reported from the administration of nifedipine to 39 patients with arterial hypertension. Thirty one of the patients suffered from hypertonic disease, and 8 had symptomatic hypertension. Light hypertension was established in 26 of the patients, moderate--10 and grave--3. In 22 of the patients (66.6%)--16 with light and 6 with moderate hypertension, the arterial pressure was normalized by the administration of nifedipine alone, 40 mg daily. In 16 patients the arterial hypertension was coped with the addition of beta-blockers, diuretic and clonidine. Only one patient failed to respond to the treatment. The effect advanced on 3rd--4th day on the average with the treatment with nifedipine alone and after 4-6 days after the inclusion of the double combination. Negligible and transitory adverse effects were observed in single patients. Nifedipine, administered alone or in combination with beta-blockers, diuretic and clonidine is an excellent agent in the treatment of light and moderate arterial hypertension.

Adult↗