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D Morales

Publications and source records attributed to D Morales.

40 records · Page 3Linked to original sources
PubMedDate not supplied

Effect of dietary nucleotides on intestinal repair in rats with experimental chronic diarrhea.

Nucleic acid synthesis in tissues of rapid growth is preferentially done using dietary purines and pyrimidines via the salvage pathway. In the case of a low protein intake, dietary nucleotides may be semiessential for cell replication of gut, lymphocytes, and bone marrow, and especially in those intestinal diseases in which the mucosa is altered, dietary nucleotides may have a role in intestinal development. The effect of dietary nucleotides on intestinal weight and length, gut mucosal weight, intestinal protein and DNA contents, and lactase, maltase, and intestinal mucosal activities was assessed in a controlled way. Weanling (21-day-old) rats were separated into two groups of 36, each receiving blindly a basal diet containing glucose polymers (C) or a basal diet with lactose as the main carbohydrate (L) for 15 days. Those fed with L developed a syndrome of chronic diarrhea and malnutrition. Ten rats of each group were sacrificed at that time. The rest of the animals of each group were separated into two subgroups. The first was fed with the C diet and the second with the C diet supplemented with 50 mg/100 g of each of the following nucleotides: AMP, GMP, CMP, UMP, and IMP (CN). Thus the subgroups CC, CN, LC, and LN were formed. Rats were sacrificed after 4 weeks and gut separated into three segments corresponding to duodenum, jejunum, and ileum. Analysis of variance was used to compare the effect of diet or segments. DNA and lactase, maltase, and sucrase activities increased in the LN group with respect to LC especially in jejunum and ileum but there were not any differences between CC and CN.(ABSTRACT TRUNCATED AT 250 WORDS)

Administration, Oral↗
PubMedDate not supplied

[Epidemiologic profile of transtelephonic electrocardiography in El Salvador during 1994].

UNLABELLED: A total of 3,787 electrocardiograms were obtained with transtelephonic monitors (TT-ECG) during 1994 in CardioTel of Central America, Nueva San Salvador, El Salvador. Each case was evaluated in terms of patient's risk and classified as high or low risk on basis of its clinical profile. There were 3,441 traces of low risk patients and 346 of high risk one. Female patients accounts for 64.7% of cases, with 35.3% corresponding to males. Of all the TT-ECG's a 52.3% were normal. Subjects older than 60 years (independently of risk had a greater probability of an abnormal TT-ECG; in the same way there was an statistically significative increase in the incidence of abnormal TT-ECG in high risk subjects compared with low risk ones. In respect to specific TT-ECG abnormalities against cardiovascular risk, a high risk condition implied a greater incidence of bundle branch blocks, signs of myocardial lesion/necrosis, left ventricular hypertrophy, sinus tachycardia and bradycardia, atrial fibrillation and premature ventricular and supraventricular complexes, with a p value of 0.05 of 0.001. CONCLUSIONS: TT-ECG is useful in the search of cardiovascular disease, regardless the presence or absence of symptoms. Age greater than 60 years and high cardiovascular risk implies a greater probability of abnormal TT-ECG.

Adult↗