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Biomedical subjects

D Mottier

Publications and source records attributed to D Mottier.

At least 73 records · Page 4Linked to original sources
PubMed1985

[Phenotype of the mononuclear cells of the cornea in ocular herpes].

There is now a great deal of evidence for cell-mediated immunopathogenesis of herpetic stromal keratitis. However, this has never been unequivocally demonstrated, so far. Accordingly, we established a new technical approach in which lymphocytes were cornea-eluted, further purified and characterized by means of monoclonal antibodies. Four corneal specimens were obtained after penetrating keratoplasty. The patients suffered from herpetic interstitial keratitis with perforation of the cornea. The most relevant point to emerge from this experiment is the marked infiltration of corneal buttons by suppressor/cytotoxic T cells. This finding strongly supports the recent suggestion, by Ahonen and coworkers that lymphocytes might be cytotoxic for keratocytes.

Antibodies, Monoclonal↗
PubMed1985

[Pure hypertensive nephropathy associated with malignant arterial hypertension in disseminated lupus erythematosus. Case with a favorable outcome].

The authors report the association of a clinically florid form of lupus with malignant hypertension and renal failure. The renal histology revealed lesions of nephroangiosclerosis, with virtually no signs of lupus proliferative glomerulonephritis. With a follow-up period of 42 months, the renal function has returned to normal, although steroid treatment has been interrupted for 33 months. However, intensive antihypertensive treatment is still required. This unusual case is discussed in the light of previous reports in the literature of the association of disseminated lupus erythematosus and malignant hypertension, which is nevertheless a rare entity.

Adolescent↗
PubMed1985

[Influence of treatment on the chemotaxis of polymorphonuclear neutrophils in rheumatoid arthritis].

The chemotaxis of neutrophil polymorphonuclear cells was measured in 56 patients with rheumatoid arthritis classified according to the treatment received. The presence of D-penicillamine in the serum affected the migration of the neutrophil polymorphonuclear cells in both the control subjects and the patients. In the patient group, the chemotaxis of the neutrophil polymorphonuclear cells was corrected non-significantly in the presence of control AB serum.

Adrenal Cortex Hormones↗
PubMed1984

[Lambert-Eaton syndrome and myasthenia. Nosologic discussion].

The Eaton-Lambert syndrome is a presynaptic neuromuscular blockade with well-defined electrical characteristics. It contrasts with the postsynaptic neuromuscular blockade which typifies myasthenia gravis. A review of the literature shows that cases do not always perfectly fit the description by Eaton and Lambert and that both kinds of blockade may be associated as in the observation reported here. Since its first description in 1956, there have been many publications on the Eaton-Lambert syndrome. However, there are cases in which both types of blockade; i.e. myasthenic and pseudo-myasthenic, are associated and the following case-report has seemed to us worthy of interest.

Carcinoma, Small Cell↗
PubMed1984

[Yersinia enterocolitica septicemia occurring in a hospital milieu. A case with septic shock in an immunocompromised patient].

A case of Yersinia enterocolitica septicemia is reported. This case is unusual as the infection was apparently acquired within the hospital and septic shock occurred during the course. Immunodeficiency, which is nearly consistent in similar observations and was established in the index case, was apparently caused by protein-calorie deficiency, without any of the usual associations reported in the literature.

Aged↗
PubMed1984

[Gougerot-Sjögren syndrome and monoclonal immunoglobulin].

Serum electrophoresis and immunoelectrophoresis were performed in 67 patients with Sjögren's syndrome. We found a monoclonal gammapathy in 11 cases: IgG (10 cases) and IgM (1 case). 1 monoclonal gammapathy was detected in 2 of 21 patients with primary Sjögren's syndrome. All patients with monoclonal gammapathy were asymptomatic.

Adult↗
PubMed1984

[Early cerebral vascular accidents in treated Horton's disease. Responsibility of the corticoid treatment?].

Two cases of strokes in the vertebrobasilar territory were observed in patients with Horton's disease during the first week of treatment when the inflammatory process seemed clinically and biologically under control. The mechanisms of arterial ischaemia are discussed: specific localisation of giant cell arteritis, associated atherosclerosis, failure of therapy or a possible inducing role of steroid therapy as the chronology of these cases would suggest.

Adrenal Cortex Hormones↗
PubMed1984

[Estrogen-progestogen agents and megaloblastic anemia].

TwO cases of megaloblastic anaemia, of which one was very severe, occurring in women who had been taking oestrogen-progestogen oral contraception over a long period of time, are reported. The authors take the opportunity, after having reviewed the literature, of pointing out the role of oestro-progestogen products in bringing about vitamin deficiencies. They discuss how and where oestrogen-progestogen products work on folic metabolism and emphasize that there is an associated factor which starts off the deficiencies.

Adult↗
PubMed1983

[Prevalence of protein malnutrition on admission in internal medicine. Study of 260 hospitalized adults].

The nutritional protein status of 260 unselected adult patients admitted to an internal medicine hospital unit and of 60 healthy controls was evaluated by measurement of the brachial muscular perimeter and of the weight--height ratio and by assay of serum albumin, prealbumin, retinol-binding protein and transferrin. The values most frequently low were those of retinol-binding protein (66%), prealbumin (42%) and albumin (25%). The sensitivity of short half-life serum protein assays is underlined. Twenty-eight p.cent of patients were found to have protein malnutrition on admission, most of these being women and patients older than 60 years. In view of the scattering of most values in controls according to age and/or sex, it is suggested that individual reference values should be determined for this type of study and that no comparison should be made with data found in the literature.

Adult↗
PubMed1983

Critical study of staging in multiple myeloma.

130 patients with multiple myeloma were reviewed for a retrospective study of their classification according to Durie & Salmon. No significant difference was found in survival between patients in stages I, II and III (median survival 24.8, 32.1, and 17.3 months, respectively). Of the classical criteria affecting survival, only the Hb level showed any significant influence (P less than 0.04). In accordance with this finding, the survival time was much shorter (P less than 0.001) in patients with renal failure than in patients without (median survival 7.4 and 24.8 months, respectively); in addition, thrombopenia, fever, old age, and above all, the % of bone-marrow plasmocytes present, were shown to be decisive factors.

Actuarial Analysis↗