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Biomedical subjects

D N Edwards

Publications and source records attributed to D N Edwards.

5 recordsLinked to original sources
PubMed1979

Histological grade and other prognostic factors in relation to survival of patients with breast cancer.

Records of 3085 patients registered with breast cancer at the Mersey Regional Cancer Registry have been analysed to evaluate the relative importance of possible prognostic factors. In a subgroup of 1759 patients, clinical stage and histological grade are shown to be strongly related to survival after treatment. In addition histological grade is related to the distribution of times to death after treatment. The results of this and 3 other studies have implications for the design and analysis of clinical trials in the primary treatment of breast cancer.

Age Factors↗
PubMed1978

The treatment of carcinoma in situ of the uterine cervix in the Mersey Regional Cancer Registry Area with some comments on incidence.

One thousand and twenty-four patients were registered with carcinoma in situ of the cervix at the Mersey Regional Cancer Registry from 1962 to 1973. The number of new cases reached a peak in the over-35s during 1968-70, but later in the under-35s. Fifty-five per cent of patients were treated initially by hysterectomy and 39% by cone biopsy or amputation. In the former group two patients developed invasive recurrence and one patient in situ recurrence. In the latter group one patient developed invasive recurrence and 15 patients developed in situ recurrence. This evidence is in agreement with other studies and supports the view that cone biopsy is an effective treatment for c. in situ of the cervix.

Adult↗
PubMed1976

Sex dependence of human intracranial gliomata.

The age and sex distribution of 1223 cases of intracranial gliomata, diagnosed in the geographical area covered by the Mersey Regional Cancer Registry over the period 1961-70, are analysed. In children and adults, the intracranial gliomata predominates in males, the tumour incidence figures indicating a ratio of 3 : 2. For young adults, the tumour incidence increases with age and is approximately the same in males and females. It is not until the age group 45-49 years is reached that the tumour incidence in males is higher. The peak tumour incidence occurs at the same age in both sexes (60-64 years) and thereafter incidence declines with age. These results are compared with previously published human data, and with the findings of experimental studies in the rat. Factors including naturally occurring changes in the hormone levels are discussed, in an attempt to explain the observed age-related sex differences.

Adolescent↗