[Evaluation of thrombinogenesis in the diagnosis of hemorrhagic diathesis].
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Biomedical subjects
Publications and source records attributed to D N Ishmukhametova.
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From the analysis of information on 158 patients who underwent operation for aneurysm of the abdominal aorta and on the basis of complications associated with impaired hemostasis, considerable disorders were revealed in the blood rheologic and coagulative properties. These disorders intensify during the operation and in the first 3 postoperative days and may lead to the development of microcirculatory and thrombotic complications. The syndrome of generalized intravascular coagulation may develop in patients with large aneurysms of the abdominal aorta, in which operations are most traumatizing. A scheme for correcting disturbances in the blood rheologic and coagulative properties in the pathological condition is given.
The values of blood coagulation and red blood were studied in 74 patients with various forms of atherosclerotic affection of the abdominal aorta and its branches. Tendency towards hypercoagulation both before operation and in various periods after it was revealed in these patients. The development of thrombotic complications is preceded by a marked increase in the fibrinogen level and in the blood platelet count. High hematocrit with a relatively small erythrocyte count and hemoglobin concentration was revealed, which was linked with the spheric shape of the erythrocytes. It is concluded that a complex of antithrombotic therapy is necessary; it should be begun before the operation and continued particularly actively in the first two postoperative weeks.
The authors confirm a well-known statement concerning a direct correlation between phagocytic activity of neutrophiles and the degree of oxygenation of an organism. According to their findings the percentage of phagocytic neutrophiles and absorbing activity of phagocytes is cases with a "blue type" heart disease is significantly lower than in patients with moderate hypoxemia. The development of an infectious process has been proved to occur in patients with a low immunoreactivity against the background of a further decrease of natural immune protection factors of an organism.
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