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Biomedical subjects

D N Osegbe

Publications and source records attributed to D N Osegbe.

28 records · Page 2Linked to original sources
PubMed1985

The causes of male infertility in 504 consecutive Nigerian patients.

The causes of infertility in 504 men were studied prospectively. The major causes were varicocele (28.8%), infection (20.8%), bilateral testicular failure (15%), idiopathic oligospermia (6.6%), multifactorial (5.6%), cryptorchidism (4%), sexual problems (3.8%) and surgical injury (1.6%). Unilateral testicular torsion and sickle cell disease though of less frequent occurrence were of particular interest because their roles are only now beginning to be realized. Gonadotrophin deficiency was an insignificant cause of subfertility. In spite of the high incidence of infection and past history of urethritis Neisseria gonorrheae was surprisingly not isolated from any patient. Compared with Caucasian studies, the high incidence of infection, and the low incidence of gonadotrophin deficiency are major points of difference.

Adult↗
PubMed1984

Haematuria in Nigerians: a prospective study.

One hundred and ninety Nigerians who presented with haematuria at an out-patient department were fully investigated and treated. There were 135 males and 55 females of mean age 37.8 years. Fifty-eight per cent of them presented over 3 months after onset of symptoms. Haematuria was severe in 27%, painless in 50%, intermittent in 26%. Infection accounted for 22.6%, neoplasms 17.4%, schistosomiasis, 14.2%, trauma 13.7%, benign prostatic hyperplasia 7.9%, calculous disease 7.9% and haemoglobinopathy 2.6%. There was no case of haematuria due to Hb type AS. Aetiology was unknown in 1.6%. Urethrocystoscopy and intravenous urography were the most rewarding investigations. All patients with carcinoma of the bladder presented very late and none survived more than 1 year after diagnosis. Eighty-six per cent of the cases were of non-schistosomal origin and the need for early and thorough investigation of haematuria is stressed.

Adolescent↗
PubMed1982

Carcinoma of the male breast in West Africans and a review of world literature.

Twelve West African men with carcinoma of the breast were treated at the Lagos University Teaching Hospital over a ten-year period, 1971-1980. These cases represent 2.4% of both male and female breast carcinomas treated at the hospital. The mean age was 56.3 years. The left breast was involved 11 times more often than the right. There were no other associated malignancies. Tumor was preceded by gynecomastia in 22% of the cases. Neither trauma, estrogen therapy, nor irradiation appeared to be etiologic factors. The majority of the lesions were advanced. Simple or extended simple mastectomy followed by external radiotherapy was the treatment of choice. There were long delays before patients sought help at a hospital. This was in part because local remedies were tried before resorting to a hospital. The five-year survival rate was 22.2%. The advanced stage of the tumor before surgery rather than race accounted for the low survival rate.

Adenocarcinoma↗
PubMedDate not supplied

True hermaphroditism in older patients: problems of diagnosis and management.

Four new cases of true hermaphroditism in older patients are herein presented. The diagnosis was delayed in all 4 patients and not made in 3 until feminization had occurred. The clinical features, the sex of rearing, gonadal locations, sex chromosomes, treatment and fertility potentials of these patients are discussed. Problems encountered in the management of these older patients underscores the need to exclude at birth bisexuality in any patient with perineal hypospadias and crytorchidism.

Adolescent↗
PubMedDate not supplied

Pulse pattern of luteinizing hormone (LH) in patients with varicocele: a preliminary report.

Serum concentrations of LH were measured every 20 minutes for 6 hours in 4 varicocele patients and 4 control subjects. In both groups, a pulsatile pattern of LH secretion was observed. Also in the two groups, LH pulse rate (2-5/6 hour) and amplitude (23.5-61%) were identical. These findings suggest that Gonadotrophin releasing hormone (Gn RH) and LH secretions have no role in the deranged sperm parameters often found in infertile men with varicocele.

Humans↗
PubMedDate not supplied

Torsion of testis in Nigerians.

Torsion in a black population is presented. The clinical features are the same as the white counterpart, but the mean age is, however, much higher. There is no bias against any side of testis. Physicians are to blame for the poor salvage rate. Gangrenous testes should not be conserved and early diagnosis and treatment remain the only means of saving torted testis. Prophylactic fixation of contralateral testis is mandatory and must not be postponed. External manual detorsion is not a substitute for surgery and should not remove the sense of emergency. Relevant pathology, the mechanism of torsion and differential diagnosis are discussed.

Adolescent↗