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Biomedical subjects

D N Shivpuri

Publications and source records attributed to D N Shivpuri.

At least 19 recordsLinked to original sources
PubMed1979

Allergenic factors and symptomatology of respiratory allergy patients.

An attempt has been made in the present study to find out the relationship between the symptomatology of nasobronchial allergy patients of Delhi with markedly positive skin reactions and prevalence of total pollen concentration in the atmosphere, concentration of major individual pollen types, total fungal spores and house dust mites together with climatic factors such as mean monthly temperature and relative humidity. A statistically significant correlation was not found between symptomatology of the patients of Delhi and mean monthly relatively humidity, atmospheric concentration of pollen, fungal spores and house dust mites. A significant negative correlation was observed between symptomatology of patients and mean monthly temperature. Except for the pollen of prospis which showed significant positive correlation with the symptomatology of Delhi patients, a significant positive correlation was absent with respect to other individual pollen types.

Allergens↗
PubMed1979

Studies on allergenic algae of Delhi area: botanical aspects.

To study distribution of algae in and around Delhi aerobiological surveys were undertaken for two consecutive years (September, 1972, to August, 1974). The surveys were accomplished by (a) slide exposure method and (b) culture plate exposure method. A total of 850 slides were exposed using Durham's gravity sampling device. Of these, 560 slides were exposed during 1973 (272 slides at two meter and 288 at ten meter height) and the rest (290 slides) were exposed during 1974 at ten meter height. A total of 858 culture plates were exposed (276 for one hour and 282 for two hours) during 1973 and the rest (300 culture plates) were exposed during 1974 at ten meter height for two hours duration only. Air was found to be rich in algae flora during the months of September to November. The dominant forms of algae present were all blue greens. This might be due to the relative greater resistance of blue green algae to unfavorable conditions.

Air Microbiology↗
PubMed1979

Respiratory allergy to algae: clinical aspects.

A comprehensive investigation was done to evaluate the allergenic algae in the Delhi area. Results of 4,000 skin tests performed on 400 patients suffering from naso-bronchial allergy and 300 skin tests on 30 healthy persons with 10 common algae isolated from the Dehli atmosphere are presented and compared. Positive skin reactions (1+ to 3+) to algae extracts ranged from 25.7% with Lyngbya major extract to 1.7% with Oscillatoria simplicissima extract; in healthy non-allergic volunteers there were no positive skin reactions. The Prausnitz-Küstner (PK), bronchial provocation and conjunctival tests were negative in patients with negative skin reactions; in patients with positive skin reactions PK was positive in 70.9%, bronchial provocation in 50% and conjunctival in 48.5%. Levels of total IgE in patients with naso-bronchial allergy were higher, ranging from 1,225 international units per ml to 1,550 international units per ml, while in healthy volunteers the values were less than 885 international units per ml.

Allergens↗
PubMed1979

New allergenic pollens of Delhi State, India, and their clinical significance.

Antigenic extracts of 26 new pollen types were assessed on 175 patients with respiratory allergy for their allergenicity, using the intradermal test. A total of 4,550 intradermal tests were performed in addition to 1,040 skin tests performed on 40 non-allergic healthy individuals as a control. Fisher's Extract Probability Test was used to determine the statistical significance of the allergenicity, expressed in percentages of markedly positive skin reactions (2+ and above). Only 13 of the 26 pollen types investigated proved to be statistically significant as possessing allergenicity. The relative sensitivity of different diagnostic tests was also assessed. Markedly positive reactions evaluated by Passive Transfer (P-K), conjunctival and bronchial challenge tests were found to be equally significant. The P-K and bronchial challenge tests gave significant correlation with markedly positive intradermal tests.

Allergens↗
PubMed1975

A study of serum immunoglobulins including IgE and reaginic antibodies in patients with bronchial asthma in relation to the spectrum of the disease.

Immunoglobulins G, A, M, D, and E were studied in the sera obtained from sxity-nine bronchial asthma patients, who were graded objectively according to atopic score. Among other associated atopic diseases, they often had allergic rhinitis. Ninety-one per cent of these patients had elevated serum IgE levels and the mean level of serum IgE was more than 3-5 times higher than that observed in the normal subjects. Moreover, as their atopic score increased, the serum IgE levels were also elevated, and every patient with high atopic score, had elevated serum IgE levels. This indicates the association of atopic state with serum IgE level. Furthermore, reaginic antibodies were studied in some of these patients by intradermal tests, Prausnitz-Küstner (PK) reaction, conjunctival and bronchial provocation tests. Intradermal and PK tests were comparable and proved to be the most sensitive method of detecting reagins. The intensity of these reactions correlated significantly with serum IgE LEvel, although this relationship is not invariably present. The reaginic activities in the sera of the patients with atopic bronchial asthma also compared well with the positive bronchial test (induced asthma) by inhalation of specific aerosol although this association is also not always present. Eleven patients with high atopic score had isolated serum IgA deficiency. There was a significant rise of mean serum IgM in comparison to the controls.

Adolescent↗