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Biomedical subjects

D Novak

Publications and source records attributed to D Novak.

84 records · Page 5Linked to original sources
PubMedDate not supplied

[Monoclonal antibodies in the diagnosis of breast carcinoma].

The knowledge of immunological reaction against tumor results in using of immunological methods in identification and characterisation of tumor antigens, and also in diagnosis and prognosis of malignant diseases. Identification of tumor antigens by monoclonal antibodies has been an important development in breast cancer research. A number of monoclonal antibodies produced against breast cancer antigens do not detect "tumor-specific" antigens, but, rather, they react with normal or modified tissue antigens which are inappropriately expressed upon malignant cells. The application of several monoclonal antibodies in combination has a potential value in immunohistopathology as diagnostic tools for recognition of small quantities of malignant cells, of premalignant changes, of histological origin of the metastases, or in the development of serum assays for tumor markers. Some of monoclonal antibodies produced against breast cancer antigens, and also attempts of their application in the diagnosis and prognosis of breast cancer, are presented in this review.

Antibodies, Monoclonal↗
PubMedDate not supplied

Evaluation of a smoking cessation program for pregnant minority women.

The purpose of this project was to develop and test culturally appropriate, low literacy, smoking cessation intervention materials designed to increase quit rates and prevent relapse postpartum for low-income African American and Hispanic women. A quasi-experimental, pretest-posttest design was used. Four Women, Infants, and Children (WIC) clinic sites in south and central Los Angeles were identified, pair-matched based on ethnic mix, and randomized to intervention (2 sites) or control status (2 sites). Participants were 18 years of age or older and either current or exsmokers (stopped smoking in the past year). The intervention group received the "Time for a Change: A Program for Healthy Moms and Babies" program including a 15-minute one-to-one counseling session and self-help guide, incorporating behavior-change strategies, booster postcard, and incentive contest. All materials were designed to match the cultural, language, and literacy needs of the target population. The smoking cessation intervention had a positive impact on both quit-smoking behavior during pregnancy and relapse prevention postpartum. Almost twice as many smokers in the intervention group (43%) reported quitting smoking at 9 months, compared to the control group (25%) (P < 0.01). At 6 weeks postpartum, 25% of the intervention baseline smokers were abstinent, compared to 12% of the control group (P < 0.01). Although no significant differences were observed for relapse during pregnancy among exsmokers at 6 weeks postpartum, a significantly higher proportion of intervention exsmokers were still abstinent (79%), compared to control exsmokers (62%) (P < 0.01). For the exsmokers, relapse prevention rates remained significant when adjusted for cotinine validated abstinence.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗