Direct chemical stimulation With carbachol in the hypothalamus of the rabbit caused a significant increase in food intake, as a function of place stimuilated and concentration. Lower doses of carbachol injected near the supraoptic nuleus produced an increase in drinking without an increase in eating.

Animals↗

PubMed1966

Effects of intravenous injections of water on the consummatory behavior of rats.

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Animals↗

PubMedDate not supplied

Facilitation of recovery by propantheline bromide after lateral hypothalamic damage.

Following lateral hypothalamic (LH) lesions rats pretreated with propantheline bromide, a peripherally-acting antimuscarinic, ate significantly sooner and at higher body weights than saline pretreated controls. The present results could not readily be accounted for by the widely held explanations of an alteration in body weight-set point, or the occurrence of denervation supersensitivity or regeneration of damaged neural processes. Therefore, it is suggested that propantheline most likely facilitated functional recovery of ingestive behaviors by acting as a prophylaxis against the viscero-metabolic disorders typically induced by LH damage.

Animals↗

PubMedDate not supplied

The metabolic bases for "paradoxical" and normal feeding.

Hexoses infused slowly into the duodenum or hepatic-portal vein reduce feeding. However, hexoses can increase food intake following rapid infusion via either of these two routes. Insulin responses and resultant glycemic changes differ following fast and slow duodenal glucose infusion. This is unlikely to be the primary explanation, because fructose affects feeding but is not a secretagogue of insulin under our testing conditions. In follow-up studies, we infused glucose or fructose into the hepatic-portal vein at the fast or the slow rate, and measured 14C incorporation into liver mitochondria and glycogen, and tritiated water uptake into hepatic lipids. Fast infusion of glucose or fructose increased lipid formation, reducing mitochondrial uptake and glycogen formation, and was associated with hunger enhancement. Slow hexose infusion was associated with substrate uptake into mitochondria and glycogen, with reduced uptake into hepatic fat. These findings all are consistent with the previously observed positive correlation seen between mitochondrial oxidation and satiety (28).

Animals↗

PubMedDate not supplied

Afferent projections to the dorsal motor nucleus of the vagus.

The afferent projections to the dorsal motor nucleus of the vagus (DMN) were investigated by iontophoretically infusing horseradish peroxidase (HRP) into that neural region of the rat. After the tetramethylbenzidine histochemical procedure was performed on the HRP-injected brains, projections to the DMN from several areas were observed including the nucleus reticularis parvocellularis and gigantocellularis, the nucleus of the solitary tract, the nucleus raphe obscuris, the principal sensory trigeminal nucleus, and the paraventricular nucleus of the hypothalamus. The pathway originating in the paraventricular nucleus was the only forebrain projection to the DMN, a finding compatible with observation of other investigators.

Afferent Pathways↗