[Chromosomal deviations in subfertile men and their partners is often not a reason to refrain from intracytoplasmic sperm injection].
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Chromosome Aberrations↗
Biomedical subjects
D O Gebhardt
Publications and source records attributed to D O Gebhardt.
[Emphasizing of ethical criteria for medical scientific reporting and the Declaration of Helsinki].
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Ethics, Professional↗
[Four new drugs for glaucoma: apraclonidine, brimonidine, dorzolamide and latanoprost].
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Adrenergic alpha-Agonists↗
[Misunderstanding of disciplinary decisions].
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Academies and Institutes↗
Topical mitomycin C for the treatment of conjunctival and corneal epithelial dysplasia and neoplasia.
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Administration, Topical↗
[A patient with an unexplained low level of high-density-lipoprotein cholesterol].
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Anabolic Agents↗
[Medical disciplinary jurisprudence in The Netherlands; a 10-year survey].
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Humans↗
[The essence of the Law on Population Screening].
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Humans↗
Decrease of intraocular pressure after subconjunctival injection of mitomycin in human glaucoma.
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Anti-Bacterial Agents↗
Bilateral simultaneous surgery.
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Contraindications↗
[Reasons to report or not report side effects of drugs to the national monitoring system in The Netherlands].
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Drug Monitoring↗
[Information and consent in health care; current developments].
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Communication↗
[The Law on Mass Screening].
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Health Services Research↗
Mitotane (o,p'-DDD) administration raises the serum level of high density lipoprotein (HDL) in normotriglyceridemia.
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Adrenal Gland Neoplasms↗
The distribution of o,p'-DDD (mitotane) among serum lipoproteins in normo- and hypertriglyceridemia.
We found that the distribution of the lipophilic chemotherapeutic agent o,p'-DDD (mitotane) among serum (lipo)proteins was altered in hypertriglyceridemia, with relatively more o,p'-DDD accumulating in the chylomicron and very-low-density lipoprotein (VLDL) fraction. Intralipid, an artificial chylomicron emulsion, or isolated VLDL could extract o,p'-DDD from the other serum (lipo)proteins. There was an inverse relationship between the relative amount of o,p'-DDD found in the fraction exhibiting a density of less than 1.006 g/ml (chylomicrons plus VLDL) and the relative amount observed in the LDL or HDL fractions of serum. Our results indicate that hypertriglyceridemia may impede the entry of o,p'-DDD into the brain or the adrenals. For therapeutic monitoring of o,p'-DDD levels in severe hypertriglyceridemia, we recommend that the chylomicron and VLDL fraction first be removed from the serum by ultracentrifugation.
Adrenal Cortex Neoplasms↗
Quantitative determination of plasma lipoproteins.
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Cholesterol, HDL↗