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D O Lyon

Publications and source records attributed to D O Lyon.

5 recordsLinked to original sources

Effects of phenytoin on schedule-controlled performance of rats.

The present study examined the effects of acute administrations of phenytoin on the lever pressing of rats maintained under fixed-ratio, fixed-interval, and interresponse-time-greater-than-T schedules of food delivery. The drug typically produced dose-dependent decreases in response rates under fixed-ratio and fixed-interval schedules, while response rates under the interresponse-time-greater-than-T schedule were affected little by the drug. These findings indicate that phenytoin effects on schedule-controlled responding differ from those of other anticonvulsants.

Animals

Pavlovian conditioning of shock-elicited aggression: a discrimination procedure.

Two auditory stimuli, separated by a fixed intertrial interval, were alternately presented to two rats in a closed environment. The positive conditioned stimulus (CS+) terminated with the offset of a 2-mA, 0.75-sec shock. The negative conditioned stimulus (CS-) terminated without shock. The incidence of the "stereotyped fighting posture" was recorded during the CS+, the CS-, the intertrial interval, and shock. The results showed an increase in the percentage of conditioned responses during the CS+, and a decrease during both the CS- and the intertrial interval, when the duration of the conditioned stimuli and the intertrial interval was 16 sec. Appropriate changes in the incidence of aggression during the two stimuli were obtained following the reversal of the stimulus functions. During the acquisition and reversal phases there was a between-session decrement and a within-session improvement in the incidence of aggression during the CS+, defined as warm-up. The presentation of free shocks before the conditioning sessions was effective in reducing the warm-up only when the interval between shocks was 64 sec. These data were interpreted as demonstrating classical conditioning of shock-elicited aggression, with little chance of non-associative factors contributing to the measurement of the conditioned response.

Aggression

The post-reinforcement pause.

Measurements of the post-reinforcement pause and response rate were obtained from four birds on a range of fixed ratio schedules from 25 to 150. The results indicated a consistent increase in the length of the pause as the ratio was increased. Response rate tended to decrease, but these data were less consistent and some reversals were apparent.

Animals

Conditioned suppression and variable ratio reinforcement.

Conditioned suppression is a decrease in response rate during a relatively short duration stimulus that terminates independently of the animal's behavior and coincidentally with a brief unavoidable shock. The degree of conditioned suppression was measured for each of three birds on three variable ratio schedules; that is, the number of responses required for food reinforcement was varied around a mean of 50, 100, or 200. The results indicated a slight and possibly negligible decrease in the degree of suppression as the mean number of responses required on the schedule was increased from 50, to 100, and 200. In general, it was found that all of the variable ratio schedules tested were quite insensitive to the conditioned suppression procedure, although almost complete suppression was obtained on a few occasions. Since the reinforcement was contingent upon the emission of responses, the birds typically displayed a high rate of response during the pre-shock stimulus on all schedules. In addition, the rate during the pre-shock stimulus often changed abruptly independent of the presentation of a reinforcement. As a result of the high rate of response and the abrupt changes in rate, the degree of suppression from trial to trial was quite variable. A clear analysis of an experimental variable on this baseline is thus difficult.

Animals