Biomedical subjects

D O Mutti

Publications and source records attributed to D O Mutti.

6 recordsLinked to original sources

PubMed1992

Retinoscopic measurement of the refractive state of the rat.

Using retinoscopy, we measured the refractive state of 96 eyes of three different strains of rats: albino Sprague-Dawley, Royal College of Surgeons (RCS) with and without inherited retinal dystrophy, and lean and obese varieties of Zucker rats. Contrary to previous reports, we do not find consistent high hyperopia in the rat, but rather refractions that range from near emmetropia (-0.12 D) to extreme hyperopia (+18.95 D). This range of refractive errors suggests a poorly developed emmetropization mechanism in the rat, and that individual refractions should be performed on animals utilized in experiments where refractive state is critical.

Albinism, Ocular↗

PubMed1992

A video technique for phakometry of the human crystalline lens.

Accurate measurement of the dioptric power of the human crystalline lens is important in any study of ocular development and refractive error. Previous studies have used comparison ophthalmophakometry, measuring crystalline lens curvature and power from still flash photographs of Purkinje images I, III, and IV. This report presents a video-based technique for in vivo measurement of crystalline lens power suitable for use with children. The repeatability and validity of this video system were evaluated in comparison to a still photograph system through the measurement of anterior and posterior lens curvatures of 40 normal adults. The video system's repeatability (95% limits of agreement) was +/- 0.52 diopters for the anterior lens power, +/- 0.73 D for the posterior lens power, and +/- 0.88 D for the total lens power. The repeatability of the still flash photography system was +/- 0.78 D for the anterior, +/- 1.43 D for the posterior, and +/- 1.84 D for the lens power as a whole. An indirect method of calculating lens power using other ocular component measures gave a repeatability of +/- 1.78 D. The validity of the video system was improved by having the camera and the light source closer to the optic axis of the eye. The bias induced by having a more off-axis configuration (40 degrees separation between camera and light source) was a +0.10 D overestimation of surface power for the anterior and +0.73 D for the posterior lens surface power compared to a more coaxial arrangement (20 degrees between camera and light source). The use of video phakometry improved the repeatability and the validity of lens curvature measures relative to still flash photograph comparison ophthalmophakometry and to an indirect method of calculating lens power. This was achieved through the system's ability to analyze multiple frames, the use of a collimated light source, and the placement of the light source for the Purkinje images closer to the eye's optic axis.

Adult↗

PubMed1992

The repeatability of measurement of the ocular components.

Studies of the ocular components of refraction typically neglect issues of repeatability of measurement methods or analyze method comparison/repeatability data inappropriately using correlation. The authors have examined the repeatability of refractive error measures (retinoscopy, subjective refraction, and Canon R-1 autorefraction, noncycloplegic and cycloplegic), axial dimension measures (Allergan-Humphrey A-scan ultrasound), and corneoscopy (keratometry and KERA photokeratoscopy), and the agreement between different refractive error and corneal measurement methods on 40 pre-presbyopic normal adults. The authors plotted the difference versus the mean of two different measurement occasions (repeatability), or two different methods (agreement), to determine the bias (mean of the differences relative to zero) and 95% limits of agreement of each technique. The most reliable measure of refractive error was autorefraction with cycloplegia, with 95% limits of agreement of +/- 0.32 diopters. Cycloplegic autorefraction had no statistically significant bias compared to cycloplegic subjective refraction. Cycloplegic retinoscopy was the least reliable refractive error measure, with repeat measures on two separate occasions extending over 95% limits of agreement of +/- 0.95 D. Anterior chamber depth was reliable to +/- 0.29 mm, lens thickness to +/- 0.20 mm, and vitreous chamber depth to +/- 0.37 mm. Corneal curvature measures show keratometry to be more reliable (to +/- 0.87 D) than photokeratoscopy (+/- 2.02 D) with a statistically significant bias (paired t-test, P less than 0.0001) of 0.57 D flatter for photokeratoscopy.

Adult↗

PubMed1987

Refractive error changes in law students.

We report two separate studies: a retrospective survey and a longitudinal study; both were designed to assess the changes in refractive error of a group of young adult law students. The retrospective survey compared the previous spectacle correction to the current refractive error in the ocular examination records of 87 members of the class of 1982 law students who were examined at the University of California, Berkeley School of Optometry. Forty-one students (47.1% of the sample, 12.9% of the entire class of 318) increased at least -0.50D in myopia in at least one eye. In the longitudinal study, we followed 16 first year law students for 6 months, measuring refractive error. Five eyes (15.6%) became at least +0.50D more hyperopic, and 12 eyes (37.5%) became at least -0.50D more myopic. These data represent analysis of a small number of eyes over a short period of time. An adult myopic shift is nonetheless evident. A methodology for accumulation of more meaningful data on the specific ocular component changes responsible for this effect is discussed.

Adult↗

PubMed1987

Contact lens fitting relation and visual acuity in keratoconus.

The presence of visual decrement in keratoconus is widely recognized, but little is known about the effect of different contact lens fitting philosophies on visual acuity. We studied 10 eyes with keratoconus, each of which was tested with an automated visual acuity device while wearing rigid contact lenses of varying base curves and diameters. Lenses used were large, flat lenses and small, steep lenses, fitted from 0.4 mm flatter to 0.4 mm steeper than the average keratometric measurement in 0.1-mm increments, including parallel to the average corneal curvature. A small improvement in visual acuity was noted with the flat lenses, equalling approximately one-half line of visual acuity, which, although statistically significant, was not deemed to be clinically significant. In addition, a decrement in visual acuity of keratoconus patients with centrally placed cones was noted and is discussed.

Contact Lenses↗

PubMed1986

Artifact in optical pachometry with contact lenses in situ.

We describe a measurement artifact associated with the wearing of a contact lens during optical pachometry. The contact lens essentially magnifies the image of the cornea, creating a nonphysiological apparent increase in corneal thickness. This artifact ranges from 0.27 to 1.22% with four current extended wear hydrogel lenses, depending on lens thickness and index of refraction. The implications of this artifact are discussed relative to study design and interpretation of results for contact lens-induced corneal edema.

Contact Lenses↗