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Biomedical subjects

D O'Donnell

Publications and source records attributed to D O'Donnell.

At least 109 records · Page 6Linked to original sources
PubMed1985

Hypophosphataemic osteomalacia misdiagnosed as metastatic carcinoma. A case report.

A 60-year-old woman presented with diffuse bone pain 12 months after simple mastectomy. During investigation for metastatic disease it was realized that her pain had preceded the mastectomy by 2 years and that the biochemical and radiological findings were inconsistent with metastatic disease. The findings of phosphaturia, hypophosphataemia, normocalcaemia and normal renal function without hyperparathyroidism are discussed in the light of the rarity of such findings in a 60-year-old adult and, in particular, in a patient with cancer of the breast.

Breast Neoplasms↗
PubMed1985

Source of cadaver kidneys for transplantation at Johannesburg Hospital.

The Johannesburg Hospital Renal Transplantation Unit obtains cadaver kidneys from throughout the Transvaal; they are also exchanged with other transplantation centres in the RSA. Analysis of the cause of death of kidney donors shows that motor vehicle accidents, suicide and cerebrovascular disease make up the majority. An encouraging feature has been the significant contribution from non-teaching hospitals and private institutions in the Johannesburg area and the effort made by more remote hospitals to help to ensure an adequate supply.

Adolescent↗
PubMed1985

Acute renal failure caused by non-traumatic rhabdomyolysis. Case reports.

Four cases of severe acute renal failure are described in which rhabdomyolysis was a causative or contributory aetiological factor. This diagnosis is worthy of consideration in the alcoholic or drug-overdose patient who presents with renal impairment. The particular biochemical changes are reviewed.

Acute Kidney Injury↗
PubMed1985

Pregnancy after renal transplantation.

During the 13 year period 1971 to 1984 there were 38 pregnancies in 21 renal transplant patients at the Johannesburg Hospital. Twenty-two ended with live births and included two sets of twins; there were nine spontaneous abortions, six therapeutic abortions, and one stillbirth. Maternal complications were mild in the majority but five patients suffered deterioration in renal function, two undergoing transplant nephrectomy as a result of this. There were seven neonatal deaths, including both sets of twins; death was due to prematurity in six and congenital malformation (diaphragmatic hernia) in one. A further infant had congenital pyloric stenosis which was corrected surgically. Pregnancies were analysed according to whether or not their outcome was successful. Those with a successful outcome had less exposure to warfarin during pregnancy (p = 0.0025) and showed a tendency towards lower immunosuppressive doses of prednisone and azathioprine although these did not reach significance. Although these results indicate an unhappy prognosis for both the mother and fetus, two redeeming features are to be noted. Pregnancy outcome improved markedly in the latter years, possibly owing to non-exposure to warfarin, less immunosuppression, and improvement in neonatal care, and four of the five mothers who suffered deterioration in renal function were notoriously unco-operative in their medical care. Pregnancy can only be recommended in the transplanted patient who has stable renal function, is compliant in taking of medications, and whose graft is of such age that the immunosuppressive drug dose is minimal. Warfarin should be avoided.

Abnormalities, Drug-Induced↗
PubMed1985

Accuracy and reliability of the Del Mar Avionics pressurometer III.

We assessed the accuracy and reliability of the Avionics pressurometer, a fully automated ambulatory blood pressure recorder. Accuracy was assessed in 96 patients against the Hawksley random-zero sphygmomanometer. Two recordings were made with each device in a random sequence. No mean difference was found between methods. However, there was a marked variation in the difference between Avionics and Hawksley recordings. This was not due to variability in blood pressure alone since the agreement between Avionics and pressurometer systolic recordings (r = 0.88) was less than the agreement between sequential systolic blood pressure measurements with the Hawksley (r = 0.976, P < 0.001). In addition, a small degree of inter-device variability was demonstrated between three Avionics recorders, one device giving higher readings. Reliability was assessed in 30 patients during normal daily activities and compared with the Remler M2000. The rate of markedly artefactual recordings was higher with the Avionics. Thus, variability in Avionics recordings makes this device unreliable.

Blood Pressure Monitors↗
PubMed1983

Aortic and mitral valve replacement for bacterial endocarditis in pregnancy. A case report.

A 24-weeks pregnant woman presented with bacterial endocarditis due to Streptococcus viridans and severe aortic and mitral valve incompetence. Progressive deterioration in haemodynamic function and the presence of systemic emboli necessitated the urgent performance of aortic and mitral valve replacement; both the patient and the fetus survived. Double valve replacement for infective endocarditis in pregnancy has not previously been reported.

Adult↗