Biomedical subjects

D Okuyama

Publications and source records attributed to D Okuyama.

9 recordsLinked to original sources

PubMed1999

[Significance and effects of intraperitoneal cisplatin administration for ovarian cancer].

We studied the efficacy and safety of combination chemotherapy in which a high-dose platinum agent was administered intraperitoneally (i.p.) plus intravenously (i.v.) to 22 patients with stage III ovarian cancer. The chemotherapy consisted of etoposide (i.p.), cisplatin (i.p.), and carboplatin (i.v.). Each course was repeated every 4 weeks and a maximum of 5 courses was given in the 6 months following the initial surgery. As a control, 13 patients received different chemotherapy (CAP etc.) in which cisplatin, cyclophosphamide and doxorubicin pirarubicin hydrochloride were administered. The mean (SD) total dose of cisplatin in the patient group group (790.6 +/- 317.0 mg/m2) over the 6 months was significantly higher than in the control group (377.2 +/- 215.1 mg/m2). The overall response rate (CR + PR) 6 months after the completion (95.5%) was significantly higher in the study patients than in the control group (53.1%). The 1, 3, 5-year survival rates were significantly higher in the EPJ group (91.0, 59.0, 42.1%) than in the control group (53.8, 15.4, 15.4%). There was no significant difference in renal toxicity or bone marrow suppression (leukopenia and thrombocytopenia) between the two groups. EPJ therapy allowed an increased dose of cisplatin in the treatment of ovarian cancer without enhancing renal toxicity, resulting in higher response and survival rates. This study demonstrated that this therapy is an effective and well-tolerated regimen.

Adult↗

PubMed1995

[A case report: complete remission of stage IV uterine cervix carcinoma by immuno-chemotherapy with intraarterial infusion using implantable reservoir system].

A patient with neck lymph node metastasis from squamous carcinoma of the uterine cervix was treated by immunotherapy and neo-adjuvant intraarterial infusion chemotherapy (OK-432 ic, etoposide 25 mg/body x 7 days po, CDDP 100 mg/m2/5 hr iA, CPM 200 mg/body iv, THP 50 mg/m2/2 hr iA). Three courses of the neo-adjuvant chemotherapy were given. After the first course, the neck metastatic tumor appeared remarkably small. After the second, the neck tumor disappeared and the uterine tumor appeared small and to have good movement. Hysterectomy was performed one month after. Each tissue platina concentration (microgram/cm3) is 9.12 uterus cervix, 10.9 uterus corporis, 8.17 fallopian tube, 14.0 ovarium, 1.47-0.88 pelvic lymph node. This patient was treated with irradiation after operation, and is presently in a state of cytological complete remission. Now she continues maintenance immunochemotherapy with UFT and OK-432 with a home doctor.

Aged↗

PubMed1990

[Estimation of 3 rate constants of the 3 compartments model in PET measurement by a weighted integral method--simulation of estimation errors].

A simulation study to evaluate the errors in rate constants of the three compartment model using the weighted integral method was performed. Ten combinations of 7 kinds of weight functions, the errors were tested in 18F fluorodeoxyglucose (18FDG) study. The error factors arising in PET measurement were statistical noise, cerebral blood volume, time shift and scanning time of PET measurement. Errors in each rate constant were within the range of 10 percent and those in k1k3/(k2+k3) within 1 percent. The weighted integral method was confirmed to be a faster method than the conventional least squares method within a reasonable error range.

Body Fluid Compartments↗

PubMed1986

[A simulation study to evaluate the statistical noise and spatial resolution in image reconstruction of emission computed tomography--with respect to the optimization of the filter function in the convolution integral].

Filtered backprojection method has been commonly used to reconstruct images in the field of the computed tomography (CT). However, in the emission CT such as positron and single photon CT, poor counting static which are caused by limited dosage to patients, limited counting rate capacity and limited efficiency of the imaging device, produce a statistical noise in the reconstructed image. The magnitude of the statistical noise and the spatial resolution were evaluated for various shapes of the filter used in the convolution integrals of the filtered back-projection procedure. The statistical noise was proportional to the inverse of the root of the total number of counts for any filters. The high-frequency-cut characteristic of the filter reduced the statistical noise, but increased the spatial resolution in the images. It was possible to optimize the shape of the filter for given total number of counts and required statistical noise and spatial resolution.

Humans↗

PubMed1982