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D Ondrus

Publications and source records attributed to D Ondrus.

50 records · Page 3Linked to original sources
PubMed1988

Value correlation of alpha-fetoprotein and human chorionic gonadotropin with the results of lymphadenectomy in non-seminomatous testicular tumours.

In a group of 131 patients with nonseminomatous testicular tumours, the authors correlated the postorchiectomic levels of alpha-fetoprotein and human chorionic gonadotropin with the results of lymphadenectomy. They found 90.5% correlation of negative and 74% of positive levels of tumour markers with results of lymphadenectomy. In spite of 9.5% false positive and 25.7% false negative results the authors concluded that determination of alpha-fetoprotein and human chorionic gonadotropin is an important contribution to the detection of residual nonseminomatous tumour tissues after orchiectomy.

Chorionic Gonadotropin↗
PubMed1988

Low sperm counts as a prognostic factor of progression in stage I non-seminomatous germ cell testicular tumours.

The prognostic factors of disease progression were studied in a prospective study in patients with Stage I non-seminomatous testicular tumours. Patients received no treatment after orchiectomy until progression of disease was confirmed. The results showed a good correlation between sperm counts in semen collected around the time of orchiectomy and progression of disease. While progression of disease occurred in 9 of the 20 patients with sperm counts lower than 10 X 10(6)/ml, it was not found in any of the patients with a sperm count exceeding 10 X 10(6)/ml.

Adolescent↗
PubMed1988

[Treatment of patients with stage I non-seminomatous testicular tumors with general orchiectomy].

A group of 24 patients with non-seminomatous germ cell tumors of the testis in clinical stage I were followed in a prospective study in order to evaluate the strategy of "surveillance" consisting of regular check-up and administration of chemotherapy in the case of progression of the disease. 19 out of 24 patients (79.2%) did not require any other treatment than orchiectomy alone during an average observation time of 14.7 (3-27) months. Progression of the disease was found in 5 patients (20.8%) after an average period of 6.6 (2-10) months. Metastasizing into the retroperitoneal lymph nodes was the most frequent finding (4/5 patients); one patient had elevated levels of HCG and AFP. These 5 patients with active disease were treated by chemotherapy including a combination of cis-platin, vinblastine and bleomycin. Three patients are in complete remission, one continues to receive chemotherapy and one died following an acute complication of the cytostatic treatment. The strategy of "surveillance" requires further prospective studies to allow the recognition of risk factors for progression of the disease.

Biomarkers, Tumor↗
PubMed1987

The incidence of carcinoma in situ in postpubertal undescended testis.

In a retrospective study of 32 adult males undergoing "preventive" orchiectomy for unilateral undescended testis the average age of the patients at the time of orchiectomy was 28.3 years (range 16-63). Macroscopically, all the testes were atrophic and there was no evidence of tumour. In all surgically removed testes histological examination showed atrophied germinative epithelium and absence of spermatogenesis. In one patient, aged 16, an obvious carcinoma in situ was identified. In another 3 patients, aged 18, 19 and 29, atypical germ cells were found. Unilateral undescended testis in postpubertal patients should be treated by orchiectomy instead of orchiopexy.

Adolescent↗
PubMed1987

Prognosis of patients after retroperitoneal lymphadenectomy for clinical stage I nonseminomatous germ cell tumour of the testis.

A retrospective analysis of patients with the clinical stage I nonseminomatous germ cell tumour of the testis was performed in order to test the reliability of clinical diagnostic methods in assessing the extent of the disease, morbidity, relapse rate, and survival after retroperitoneal lymphadenectomy, and in an effort to pinpoint the risk factors leading to relapse. A total of 69 patients with clinical stage I nonseminomatous germ cell tumours of the testis underwent retroperitoneal lymphadenectomy. Metastases in the retroperitoneal space were found in 8 [11.6%] patients. Immediate postoperative complications were observed in 7.2% of patients. Loss of ejaculation was found in 52.9% of patients after bilateral, and in 21.4% after unilateral retroperitoneal lymphadenectomy. Relapse was noted in 5 out of 61 [8.2%] patients, with the relapse invariably localized in the lungs. Of the 69 patients, 65 [94.2%] are alive, free of signs of the disease at an average 5.4 years since initiation of treatment. The study did not find a correlation between relapse and histologic findings and/or the extent of the germ cell tumour.

Adolescent↗
PubMed1986

Testicular dysfunctions in patients after cytostatic treatment of non-seminomatous testis tumours.

In recent two years 28 patients were treated by combined cytostatic therapy for non-seminomatous testis tumour. Eleven months on the average since finishing chemotherapy they underwent andrological examination aimed at the changes of testicular function. Influence of cytostatics--bleomycin, cisplatinum and vinblastine on spermiogenesis of patient, on contralateral testis unaffected by tumour and on potency (data on erection, orgasm, volume of ejaculate and coitus frequency) was observed. 20% of patients had diminished contralateral testis. Decrease of ejaculate volume was stated by 64% of patients. Spermiogenesis damage was established in all patients (86% of patients had azoospermia and 14% had difficult oligoasthenospermia). One of the possible solutions of this negative effect on male fertility is represented by cryopreservation of semen before introduction of chemotherapy.

Adult↗
PubMed1982

[Significance of infiltration of the lamina propria for the prognosis of patients with bladder tumors].

3- and 5-year survival rate from 128 patients with superficial bladder cancer was evaluated. With noninvasive papillary cancer the 3- and 5-year patient survival rate was 83,6 respectively 58,1%. If the tumor had been infiltrated the Lamina propria patients survival rate was 57,5 respectively 28,7%. Combined therapy consisting in transurethral resection and irradiation should be considered for patients with infiltrating superficial bladder cancer.

Adult↗