Biomedical subjects

D Onken

Publications and source records attributed to D Onken.

12 recordsLinked to original sources

PubMed1978

["Hepatoportal pneumatosis with pneumatosis intestinalis in the neonate" (author's transl)].

A fullterm newborn infant two weeks of age, suffering from congestive heart failure due to a large patent ductus arteriosus, deteriorated suddenly presenting with a paralytic ileus. Radiographically diffuse intestinal pneumatosis and gas in the portal vein system could be shown. A mechanical reason was excluded by laparotomy shortly after which the infang died. Out of blood Klebsiella pneumonia could be grown. A survey of the literature on the syndrome of pneumatosis intestinalis and gas embolization into the portal vein system in the neonatal age group disclosed 41 cases. Based on this material etiology radiological features, differential diagnosis, prognosis and treatment is discussed in detail.

Air↗

PubMed1975

[Acute renal failure after intracranial injury in three children: analysis of possible causes (author's transl)].

In three children (aged 6-8 years)acute renal failure developed three to five days after head injury. After emergency treatment and measures to prevent cerebral oedema, two of the children were given simultaneously dextran, cefalotin, gentaminic and beta-aescin. The dosage of these drugs was much higher than the usual upper limbs, beta-aescin in doses as high as 10 to 20 fold above recommended maximum. There was no proven connection between the drugs and their dosage and renal failure, because many factors were involved. However, in intensive treatment for children an exact control of drug dosage essential because toxic side effects of different drugs can be potentiated. All three children were haemodialysed, renal function recovered and all were discharged without organic sequelae.

Acute Kidney Injury↗

PubMed1975

Stereospecificity in some central and circulatory effects of phenylisopropyl-adenosine (PIA).

The effects of l- and d-stereoisomers of phenylisopropyl-adenosine (PIA) were tested on the central nervous and circulatory system. In mice l-PIA in doses of 0.1--0.2 mg/kg i.p. reduced motor activity and muscular coordination, prolonged barbiturate sleeping time and exerted a hypothermic and analgetic effect. In most of these tests even 10--20 times higher doses of d-PIA proved to be ineffective. In isolated guinea-pig heart preparation l-PIA increased the coronary flow, diminished the contraction amplitude and frequency in approximately 1/20 of the doses than did d-PIA. Blood pressure of rats was markedly lowered by l-PIA in doses of 6--15 mug/kg i.v. but not by the same dose of d-PIA. There seems to be stereospecificity for PIA in various tissues and animals in vivo as well as in isolated organs. The l-isomer is usually 10--20 times more active than the d-form. In addition to stereospecificity at receptor sites, differences in lipid solubility of the stereoisomers could explain these findings.

Adenosine↗

PubMed1975