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D Orolin

Publications and source records attributed to D Orolin.

At least 19 recordsLinked to original sources
PubMed1992

[Isolated arteritis of the central nervous system].

Isolated arteritis of the central nervous system (CNS) is a relatively rare condition. Of the patients treated at our department two presented with characteristic features and eventually the diagnosis of isolated arteritis of the CNS was established. Headaches and relapsing lesions of cerebral nerves were predominant in the clinical picture of the first patient. In agreement with the clinical picture suggesting that small arteries were affected, the angiographic (AG) finding was negative and the diagnosis was based mainly on the positive effect of immunosuppressive treatment. The second patient with relapsing monofocal brain damage had a typical AG finding and a positive response to the treatment. The clinical picture of isolated arteritis of the CNS can be rather varied, with headaches and different neurological features being predominant. Both AG and bioptic examinations may prove negative. Positive response to immunosuppressive treatment is to be considered a characteristic feature of the disease. (Fig. 3, Ref. 11.)

Adult↗
PubMed1978

Transmissible virus dementia. I. An unusual space and time clustering of Creutzfeldt-Jakob disease and of other organic presenile dementia cases.

A peculiar grouping of Creutzfeldt-Jacob disease (CJD) and of other organic presenile dementia (OPD) cases in a small, prevalently rural area in Czechoslovakia to the east of 19 degrees 35' E and to the north of 48 degrees 15' N was studied. Between August, 1972 and November, 1976, three histologically proven CJD cases, bearing no sporadic of familial patterns, were observed. The distance between their dwellings was 13--17 km. In addition, seven cases of OPD were detected in the same area, two of them being suspected as possible CJD according to clinical evidence.

Adult↗
PubMed1978

Transmissible virus dementia. II. Neurohistology of three, geographically clustered cases of Creutzfeldt-Jakob disease.

Histopathological findings in three temporo-spatially linked cases of Creutzfeldt-Jakob disease (CJD) are reported. The patients were males, unrelated and without positive family history. Their mean age at the onset of the disease was 52.3 years. The mean duration of the illness was 6.6 months; the clinical symptomatology differed considerably. Neurohistology revealed in all patients a neuronal loss, intracyoplasmic vacuolation, spongiosis and astrocytosis. Besides the cortical regions, basal ganglia and cerebella were severely affected. All cases were pathologically suggestive of the cortico-striato-cerebella variant of CJD. Attention is drawn to this apparent topical similarity of most pronounced lesions. The possible significance of the pathoanatomical consistency, observed in the cases studied, for the unusual pattern of natural occurrence of CJD is considered.

Astrocytes↗
PubMed1976

Experimental live tick-borne encephalitis vaccine (Labgat E5 "14" virus clone): volunteers 1 and 2 years after single-dose immunization.

Groups of volunteers given intramuscularly 5 or 6.5 dex or perorally 6.5 dex newborn mouse icLD50 of the plaquesegregated "14" clone of the Langat E5 virus strain (tick-borne encephalitis comples) were followed for periods of 12 and 24-27 months. Circulating specific virus neutralizing antibodies persisted in them in the absence of apparent reaction as evidenced by clinical, electroencephalographic and cerebrospinal fluid findings.

Administration, Oral↗
PubMed1975

Further virological and clinical investigations on the attenuated E5"14" virus from the tick-borne excephalitis complex.

A total of 22 persons, given a single intramuscular dose of 3.1 times 10(6) newborn mouse ic LD50/ml of the E5"14" virus (stored for 26 months at 4 degrees C in lyophilized state), were subjected to rigorous clinical, clinical-laboratory and virological investigations. Clinical observations and laboratory tests (blood and cerebrospinal fluid cytology and biochemistry) revealed no ill-effects or deviations attributable to the immunization procedure. After administration of the immunizing dose, no viraemia was detected and specific seroconversions from negativity to positivity were found after 9 weeks in 73-82% of the subjects, using different tick-borne encephalitis (western subtype) viruses in the virus neutralization experiments. The results obtained seem to give increased confidence in the further use of this attenuated virus clone with strictly defined characteristics.

Adult↗