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Biomedical subjects

D P Abbott

Publications and source records attributed to D P Abbott.

16 recordsLinked to original sources
PubMed1991

A condition resembling pagetoid reticulosis in a laboratory mouse.

A raised, hairless cutaneous nodule was found incidentally at necropsy of a 24-month-old CD1 mouse. Histologically there was infiltration of the epidermis by a monomorphic population of moderate to large lymphocytoid cells. Many large cells had bizarre convolutions of the nuclear membrane and resembled the so-called Sézary or mycosis cells seen in epidermotropic T-cell proliferative disorders. The pattern of cutaneous involvement and the presence of the large cells with convoluted nuclei is characteristic of pagetoid reticulosis. No previous reports of such cutaneous lymphoid neoplasms in mice were found in an extensive literature search.

Animals↗
PubMed1990

Hepatocytes in the mouse stomach.

Hepatocytes occurred in the stomach as incidental findings in 4 110-112-week-old mice (3 B6C3F1 and 1 Crl:COBS-CD1) sacrificed at termination of 2-yr toxicity/carcinogenicity bioassays of unrelated chemicals. Both sexes, and control and treated animals, were affected. Grossly, 2 mice only had 1.0-5.0 mm, smooth, cream-colored nodules protruding from the glandular stomach mucosa. Histologically, the glandular stomach submucosa and lamina propria adjacent to the limiting ridge, and in one case, the forestomach submucosa had circumscribed accumulations of well-differentiated hepatocytes with abundant eosinophilic cytoplasm and round central nuclei. Adjacent gastric glands sometimes exhibited dilation, epithelial hyperplasia, mineralization and/or microherniation into the submucosa. Ultrastructurally, the hepatocytes were polygonal cells with abundant mitochondria and rough endoplasmic reticulum; intercellular bile canaliculus-like structures exhibiting intraluminal microvilli and bounded by desmosomes were also present. No evidence of hepatocellular carcinoma or primary gastric neoplasms was found. No definitive conclusions concerning cell of origin or pathogenesis of these hepatocytes could be made, but hypotheses include congenital anomaly or post-natal transdifferentiation (metaplasia).

Animals↗
PubMed1986

Calcifying epithelial odontogenic tumours in three cats and a dog.

Neoplasms histologically similar to calcifying epithelial odontogenic tumour (CEOT) of man are described in three cats and a dog. The diagnostic features of these neoplasms are their occurrence in the jaw and the histological appearance of cords of epithelial cells, amyloid spherules and foci of calcification. The histogenesis and behaviour of the tumour are discussed.

Animals↗
PubMed1984

Lymphangiosarcoma in two cats.

Cutaneous tumours consisting of irregular empty anastomosing spaces lined by spindle cells were diagnosed as lymphangiosarcoma in two cats. The tumour cells exhibited the characteristic lining up along pre-existing collagen and muscle fibres. Because of the small number of cases of lymphangiosarcoma in cats, conclusions regarding biological behaviour or breed incidence are not made.

Animals↗
PubMed1984

A survey of parasitic lesions in wild-caught, laboratory-maintained primates: (rhesus, cynomolgus, and baboon).

The lesions associated with parasitic infestation in 1156 wild-caught, laboratory-maintained nonhuman primates (Macaca fascicularis, Macaca mulatta, and Papio spp) are described. The two most common parasites seen were lung mites (Pneumonyssus spp) and nodular worms (Oesophagostomum spp). In addition, in cynomolgus monkeys (Macaca fascicularis) only, Nochtia nochti was a frequent pathogen. The etiology of mineralized fibrotic nodules in the mesentery of cynomolgus monkeys was thought to be infection with Paragonimus westermani, the oriental lung fluke.

Animals↗
PubMed1984

Spontaneous ovarian neoplasms of the laboratory rat.

A wide range of spontaneous tumors of the ovary are reported in a group of 5903 aged female Sprague-Dawley rats of the CD and CFY strains examined since 1978 in this laboratory. The most commonly observed tumor was the tubular adenoma. Others recorded were tubular adenocarcinoma, papillary cystadenoma, papillary cystadenocarcinoma, a Sertoli's cell tumor, benign and malignant granulosa cell tumors, benign thecal cell tumors, and classical mesotheliomas of ovarian origin. A system of classification and nomenclature of the ovarian tumors from this group is advanced.

Adenocarcinoma↗
PubMed1983

Mononuclear cell leukemia in aged Sprague-Dawley rats.

A mononuclear cell leukemia in Sprague-Dawley rats is described in which liver, spleen, and lung involvement was a constant feature. The cell was 16 to 25 microns in diameter with round, oval or indented nucleus, and the cytoplasm contained bright red granules. This is the first report of such a leukemia in Sprague-Dawley rats and a comparison with mononuclear cell leukemia in other strains of laboratory rats is made.

Animals↗
PubMed1983

Neuronal ceroid-lipofuscin storage in a cynomolgus monkey (Macaca fascicularis).

The light and electron microscopical characteristics of non-age-related neuronal ceroid-lipofuscinosis in a young cynomolgus monkey (Macaca fascicularis) are described. The pigment in the neuronal cytoplasm was PAS-positive, sudanophilic, weakly acid-fast, and positive with Schmorl's and aldehydefuchsin stains for lipofuscin. Ultra-structurally, it appeared as membrane-bound, electron-dense aggregates within the cytoplasm of neurones of both brain and spinal cord.

Animals↗
PubMed1975

Vaterite: a mineralization product of the hard tissues of a marine organism (Ascidiacea).

X-ray diffraction and infrared absorption spectra show that the spicules of the common tropical ascidian, Herdmania momus, are mineralized with vaterite. These are the first strictly marine organisms known to normally precipitate vaterite. The biomineralization of vaterite may constitute another link between the urochordates and vertebrates. The vaterite of ascidian spicules immersed in natural seawater remains mineralogically unchanged for 1 year, which indicates that vaterite may be preserved transiently in marine sediments.

Animals↗