Diverticular disease in urban Kenyans.
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Biomedical subjects
Publications and source records attributed to D P Burkitt.
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The prevalence of colonic-rectal cancer is generally directly related to the fat content and inversely related to the fiber content of diet. In the few exceptions to this generalization, tumor prevalence is more closely related to fiber than to fat. Hypotheses have been postulated to explain the possible ways in which dietary fiber may protect against colonic-rectal cancer and to account for the close relationships between the geographical distribution of these tumors and that of certain other diseases.
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All the results of a common cause will be related to one another. Consequently observed inter-relationships between diseases suggest some common causative factors. Certain characteristically western diseases have been shown to be related to one another in a number of different ways, including their order of emergence. This order with increasing age in western countries is the same as that of their emergence with the passage of time following the impact of western culture in developing countries. These observations are consistent with the hypothesis that they share some causative factor, and the removal of fiber from plant foods has been postulated to be such a factor.
A quarter of a century ago Professor C. F. M. Saint of the University of Cape Town noted the occasional association of diverticular disease, hiatus hernia, and gallstones in a patient. The occurrences of these diseases, and the significance of their associations, are discussed. The suggestion is made that the diseases are casually related to the consumption of fibre-depleted diets.
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The high prevalence of varicose veins in Western countries contrasts with their relative rarity in traditionally living communities in the Third World. Evidence is presented in support of the hypothesis that a major causative factor is the transmission of raised intra-abdominal pressures to the veins of the legs. One important cause of these pressures is the abdominal straining necessitated to evacuate small firm stools, which in turn are the result of fiber-depleted diets.
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