PubMed Health⌕ Search

Biomedical subjects

D P DeSimone

Publications and source records attributed to D P DeSimone.

10 recordsLinked to original sources
PubMed1993

Case report 785: Radiation-induced osteochondroma of the ilium.

A case of osteochondroma of the pelvis secondary to radiation therapy after radical nephrectomy for a Wilm's tumor is reported. The occurrence of such a complication has been discussed. Proof was obtained by open biopsy. The indications for surgical resection of such a tumor were considered. The differential diagnosis, though limited, was discussed.

Adult↗
PubMed1993

Case report 773. Radiation-induced osteochondroma of the ilium.

A case of osteochondroma of the pelvis secondary to radiation therapy after radical nephrectomy for a Wilm's tumor is reported. The occurrence of such a complication is discussed. Proof was obtained by open biopsy. The indications for surgical resection of such a tumor were considered. The differential diagnosis, although limited in scope, was discussed.

Adult↗
PubMed1992

Vascularization and endochondral bone development: changes in plasminogen activator activity.

Changes in plasminogen activator activity were studied during the sequential developmental stages of matrix-induced cartilage, bone, and bone marrow development. The morphological transitions were correlated with biochemical parameters. Morphologic evidence of vascularization of calcified hypertrophic cartilage was accompanied by a concomitant rise in plasminogen activator activity. Thereafter, a steady decline during mineralization and deposition of new bone was observed. Maximal plasminogen activator activity occurs at approximately the same time as peak activity of alkaline and acid phosphatase. These results imply a role for plasminogen activator during angiogenesis, vascular invasion, and attendant bone differentiation.

Animals↗
PubMed1989

Influence of body habitus and race on bone mineral density of the midradius, hip, and spine in aging women.

Osteoporosis and fractures of the hip are less common in black women and in obese white women than in nonobese white women. To determine the effects of race, age, and body weight on bone mineral density (BMD), BMD of the lumbar spine, trochanter, and femoral neck were determined by dual-photon absorptiometry in 131 nonobese white women and 34 nonobese black women, all of whom were within 30% of their ideal body weight, and in 24 obese white women and 27 obese black women, all of whom weighed more than 30% of their ideal body weight and were in the same age range as the nonobese women. All of them were 51 years of age or older, and most of them were postmenopausal. BMD of the midradius was measured by single-photon absorptiometry. Whereas body weight was significantly higher in the black as compared to the white women, the ages of the two groups were not different from each other. BMD declined with age and increased with body weight in both the black and white women at each of the four sites measured. After adjusting for age and weight by covariate analyses, black women had greater BMDs than white women at the midradius, lumbar spine, and femoral neck (p less than 0.001), but not at the trochanter (p = 0.18). The increases in BMD observed in the obese and black women in the present study are consistent with the previous findings that osteoporosis and fractures of the hip are less common in black and in obese white women than in nonobese white women.

Aged↗
PubMed1988

Diagnostic arthrogram of a Salter I fracture of the proximal humerus in a newborn.

Proximal humeral fractures occurring during breech delivery are rare and are generally Salter-Harris Type I physeal fractures. The absence of a radiographically demonstrable metaphysis attached to the proximal fragment of these fractures often makes them exceedingly difficult to diagnose at first. A recent case demonstrates the usefulness of arthrography and videofluoroscopy as an adjunct to plain radiography in diagnosing such injuries.

Arthrography↗
PubMed1983

Type II collagen-induced arthritis. A morphologic and biochemical study of articular cartilage.

Articular cartilage was obtained from type II collagen-induced arthritic rat joints. Transmission electron microscopy showed a gradual degeneration of chondrocytes, disorganization of the collagenous extracellular matrix, and formation of microscars. Biochemical analyses indicated that type II collagen was the only collagen present and that it was normal in regard to hydroxylation of lysine and glycosylation of hydroxylysine. Analyses of the proteoglycan in the extracellular matrix revealed a 50% loss of chondroitin sulfate and keratan sulfate.

Animals↗
PubMed1983

Influence of vitamin A on matrix-induced endochondral bone formation.

The influence of retinoic acid on matrix-induced endochondral bone differentiation was determined. Retinoic acid was administered during discrete stages of endochondral bone formation, specifically, mesenchymal cell proliferation, chondrogenesis, bone formation, and mineralization. In retinoic acid-treated rats examined on day 3 following matrix implantation, biochemical markers for mesenchymal cell proliferation were about 50% of the controls. Chondrogenesis on day 7, assessed by 35 SO4 incorporation into proteoglycans, was 27% of the control. In addition, dissociative extraction of proteoglycans with 4.0 M guanidine-HCl and chromatography on Sepharose CL-2B revealed the synthesis of a smaller molecular weight proteoglycan when compared to controls which exhibited the cartilage-specific type. Osteogenesis and bone mineralization were monitored by alkaline phosphatase activity and 45Ca incorporation. On day 11 alkaline phosphatase activity was decreased by 40% and 45Ca incorporation was 48% of the control. These results revealed the multiple foci of the actions of excess vitamin A.

Alkaline Phosphatase↗