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Biomedical subjects

D P Lynch

Publications and source records attributed to D P Lynch.

At least 19 recordsLinked to original sources
PubMed1998

The dos and don'ts of an oral mucosal biopsy performed by the general dentist.

The recognition of a pathologic entity is only the first step in the chain of events which must be performed for accurate diagnoses and appropriate patient management. Other steps include selection of the type of biopsy to be performed; proper biopsy technique, instrumentation and specimen handling; appropriate fixation; detailed documentation; and postoperative patient instructions. If the clinician performs each step carefully and correctly, the patient is ensured of receiving an accurate diagnosis in the shortest possible period of time.

Biopsy↗
PubMed1997

Oral mucosal melanomas: the WESTOP Banff workshop proceedings. Western Society of Teachers of Oral Pathology.

A workshop to discuss primary oral melanomas was convened at the annual Western Society of Teachers of Oral Pathology meeting in Bannf, Alberta, Canada. Fifty oral melanomas, identified from the files of the participants, were reviewed in order to better understand the clinical features, histologic spectrum, and natural history of these perplexing lesions. Results confirmed that oral melanomas occur in adults almost three times more frequently in men than women and have a decided predilection for the palate and gingiva. Some lesions exhibit a clinically detectable and prolonged in situ growth phase, whereas others seem to lack this property and exhibit only or predominantly invasive characteristics. Recurrences, metastases, and death from tumor were characteristic of the follow-up of a limited number of patients. Until definitive prospective data are collected that elucidate natural history, oral mucosal melanomas should be tracked separately from cutaneous lesions. All oral pigmented lesions that are not clinically diagnostic should be biopsied. Lesions with equivocal histopathologic features might be referred to as "atypical melanocytic proliferation" and should be excised. Recognition of lesions in an early in situ phase and aggressive treatment should have a favorable effect on prognosis. To enhance future or prospective study of these rare neoplasms, guidelines for reporting oral melanomas are suggested.

Adult↗
PubMed1997

Oral manifestations of HIV disease: an update.

More than 40 different oral diseases and conditions have been described in patients infected with human immunodeficiency virus (HIV). The recognition of the oral manifestations of HIV disease is of great significance because they may represent the first signs of the disease and have been shown to be highly predictive markers of severe immune deterioration and disease progression. Although some oral diseases and conditions have a weak association with HIV disease, others are strongly linked with the disorder, and a few are acquired immune deficiency syndrome (AIDS)-defining in nature. The spectrum of oral manifestations of HIV disease is reviewed with emphasis on clinical recognition, diagnosis, and treatment.

AIDS-Related Opportunistic Infections↗
PubMed1996

Oral manifestations of HIV infection.

OBJECTIVE: To provide a comprehensive, literature-based guide to the diagnosis of and the management and referral of patients with oral diseases associated with human immunodeficiency virus (HIV) infection. DATA SOURCES: The literature was reviewed to identify common oral manifestations of HIV infection, the physical and laboratory findings associated with them, and the therapies used to treat them. The National Library of Medicine's AIDSLINE database was searched using the term "mouth diseases." Additional references were identified from the bibliographies of these articles and related textbooks. STUDY SELECTION: English-language abstracts were reviewed to determine each paper's clinical relevance. To be considered clinically relevant, a paper had to describe the physical appearance of oral manifestations, methods used to diagnose oral manifestations, or treatment and referral guidelines. More than 600 abstracts were identified. DATA EXTRACTION: After the abstracts were reviewed, articles were selected and were reviewed for possible inclusion. If both of two reviewers agreed that an article was clinically relevant and dealt with conditions that occurred in more than 1% of HIV-infected patients, the article was included. DATA SYNTHESIS: 16 conditions that occur in more than 1% of HIV-infected patients were identified. Information on these conditions was collected and sorted into three categories: clinical appearance, diagnostic methods, and treatment. CONCLUSIONS: Almost all patients with HIV infection will contract oral diseases. Guidelines for recognizing, diagnosing, and managing these conditions are presented. Most conditions can be treated or alleviated through the combined efforts of the physician and the dentist.

HIV Infections↗
PubMed1996

Faculty development.

Explore the source record for details and available documents.

Cost-Benefit Analysis↗
PubMed1994

Oral candidiasis. History, classification, and clinical presentation.

Candida albicans is a ubiquitous, dimorphous yeast; it has been known for many centuries, and has the potential to cause human disease under specific circumstances and conditions. The actual taxonomy of Candida albicans and related species has only been confirmed within the twentieth century. The oral carriage rate for the organism is high, with nearly one half of the healthy population harboring the organism. Numerous predisposing factors for oral candidiasis have been recognized, including metabolic, dietary, mechanical, and iatrogenic factors. Multiple clinical forms of the disease have been described, including acute, chronic, and mucocutaneous presentations. Although rarely fatal in the absence of other serious underlying disease, oral candidiasis may serve as a useful clinical marker for the presence of significant predisposing conditions.

Age Factors↗
PubMed1993

HIV infection and AIDS in Texas. A Special Report.

Human Immunodeficiency Virus (HIV) infection and the Acquired Immune Deficiency Syndrome (AIDS) are significant public health problems in Texas. This paper summarizes the most recent information on HIV infection and AIDS from global, national, and state perspectives. Current information on the manifestations of HIV infection and AIDS which are important to dentistry, ramifications for dental health care workers, and initiatives for HIV/AIDS education for dental health care workers in Texas are presented.

Acquired Immunodeficiency Syndrome↗
PubMed1990

The oral mucosal punch biopsy: indications and technique.

The indications for advantages and disadvantages of the punch biopsy technique in the diagnosis of oral mucosal disease are discussed. The punch biopsy is recommended for use by the general practitioner as a simple, fast, inexpensive, and safe procedure for the diagnosis of oral mucosal lesions.

Biopsy↗
PubMed1988

Intraoral Kaposi's sarcoma: a correlated light microscopic, ultrastructural, and immunohistochemical study.

Oral mucosal lesions of Kaposi's sarcoma are a common finding in patients with acquired immunodeficiency syndrome (AIDS). The histologic features of Kaposi's sarcoma vary, depending on the clinical stage of the lesion. Endothelium-lined vessels are the principal feature of early, macular lesions, while spindle cells dominate late-stage, nodular lesions. The histogenesis of both components remains controversial. In this study, biopsy specimens of intraoral Kaposi's sarcoma from 10 patients with AIDS were studied by light and electron microscopic examination and by immunoperoxidase staining with the endothelial markers, factor VIII-related antigen and Ulex europeaus agglutinin I. The results of this study support a vascular origin for both the endothelium-lined vessels and the spindle cells. The latter appear to represent vascular endothelial cells in various stages of differentiation. The histologic features that are useful in the diagnosis of intraoral Kaposi's sarcoma are reviewed.

Acquired Immunodeficiency Syndrome↗