Immunogenicity of acellular pertussis vaccines using two vaccines for primary immunization.
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Biomedical subjects
Publications and source records attributed to D Palitzsch.
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A girl with mild psychomotoric retardation, dysmorphic stigmata, feeding difficulties and recurrent infections is described, who has been observed from the age of 7 months to 3 2/12 years. Chromosomal analysis revealed an unbalanced X-autosomal translocation between the greater parts of the long arm of an X-chromosome and the long arm of an chromosome 8 resulting in a partial trisomy 8q and partial monosomy Xq.
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Three members of a family showed a bifascicular bundle branch block in their electrocardiographic curves. One member had suffered from rheumatic myocarditis. The other two membranes did not show signs of cardiac disorder. The familial occurrence of conduction system disturbances are well known but has been reported infrequently. Etiology and pathogenesis are multifactorial. A definite statement with regard to the prognosis is not possible.
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Examinations of faeces (pH, Clinitest and Clinistix) are liable to contribute to the diagnosis of lactose malabsorption. To confirm the diagnosis the test is to be repeated while Lactase 500 is added to the child's milk. The enzyme does not split the lactase into the two monosaccharides, thus eliminating the malabsorption. The new drug Lactase 500 was used as a diagnostic parameter and for the treatment of lactose malabsorption in 20 infants. The effect on both groups was confirmed as mentioned by foreign authors. In addition to a very simple diagnostic method, which can be performed in the practitioner's office, there are two methods of treating lactose malabsorption: 1. feeding milk free of lactose, 2. feeding milk with an addition of Lactase 500. As in an earlier publication we assumed that about 10 per cent of the population suffers from secondary malabsorption of lactose, it seems advisable to check with the help of the described to simple methods all children with chronic diarrhoea.
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Results of the second enquiry organished by the milk-kitchen commission of the German paediatric Association. Questionnaires were sent to 500 German and foreign paediatric and obstetric departments. In paediatric departments not much has changed since the first enquiry five years ago. As then 85% of paediatric departments have a central milk-kitchen. Food is - in the main - prepared once in 24 hours. One half of them use milk powder, fluid food has risen only slightly. Bacteriologic controls of food and personel are unfortunately carried out only at too long intervals. In departments for premature infants the one-way bottle with uperised milk has been widely accepted. Almost all obstetric departments have abandoned their central milk-kitchens and provide fluid nourishment except where they are connected with the central milk-kitchen of a paediatric department. Since almost all directors of departments replied, the present result is representative and shows little change. The reasons for this are discussed and the need for careful control of feed-preparation and cooling chains emphasized. According to a recommendation of the German paediatric Association to the national Ministry of Health the handling of food for babies in paediatric departments should be brought into line with the regulations.
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