Biomedical subjects

D Paran

Publications and source records attributed to D Paran.

21 records · Page 2Linked to original sources

PubMedDate not supplied

Transient regional osteoporosis with antiphospholipid antibodies: a report of two cases.

We describe two patients with clinical, radiological and laboratory findings consistent with transient regional osteoporosis. In both cases antinuclear and antiphospholipid antibodies were found with no evidence of any other autoimmune disease. Both patients were smokers. We suggest transient ischemia caused by antiphospholipid antibodies as a possible etiological factor in this rare and poorly understood syndrome, and hypothesize that anticoagulants and abstinence from smoking may play a role in the prevention of recurrence in these patients.

Antibodies, Antinuclear↗

PubMedDate not supplied

Sleep disturbances, fibromyalgia and primary Sjögren's syndrome.

OBJECTIVE: To investigate the association and prevalence of sleep disturbances and fibromyalgia (FM) in a group of patients with primary Sjögren's syndrome (pSS). METHODS: Sixty-five patients with pSS were investigated. A 10-point Mini Sleep Questionnaire (MSQ) was completed focusing on sleep complaints. The same questionnaire was also used in three control groups: Group A-67 patients with rheumatoid arthritis. Group B-53 patients with rheumatoid arthritis (RA) and sicca symptoms; Group C-31 patients with osteoarthritis. All patients with pSS were also studied fro the presence of FM. RESULTS: Moderate or severe sleep disturbances were reported by 49 out of 65 pSS patients (75%). This frequency was significantly higher than that reported by patients in the three control groups (p < 0.001). FM was present in 36 out of 65 pSS patients (55%) and was associated with sleep disturbances. FM or sleep disturbances were not associated with any clinical or laboratory parameters. CONCLUSION: Our results suggest that sleep abnormalities and FM in pSS patients are frequent and their etiology might involve other mechanisms besides joint pain or sicca symptomatology.

Aged↗

PubMedDate not supplied

Polymyalgia rheumatica in patients with ankylosing spondylitis: a report of 5 cases.

OBJECTIVE: To report the cases of 5 elderly male patients with ankylosing spondylitis (AS) who developed polymyalgia rheumatica (PMR). MATERIALS AND METHODS: The files of 5 patients with AS who developed PMR were retrospectively reviewed. The demographic, clinical, laboratory characteristics and outcome of these patients were summarized. RESULTS: All 5 patients were male, 65-80 years old at the time of their PMR diagnosis. The diagnosis of AS was made simultaneously based on clinical and radiological data; the age at onset of symptoms retrospectively attributable to AS was 20-40 years in three cases, while in the two other patients it could not be determined. The patients presented with typical symptoms of PMR and responded to steroid treatment. HLA B27 was found in three cases, while HLA DR did not show a consistent pattern. CONCLUSIONS: The coexistence of AS and PMR could be more than coincidental. Further screening of both patient populations is needed to assess the true extent of this preliminary observation.

Aged↗