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Biomedical subjects

D Paris

Publications and source records attributed to D Paris.

45 records · Page 3Linked to original sources
PubMed1984

Use of durapatite for the rehabilitation of resorbed alveolar ridges.

These investigations were undertaken to evaluate durapatite, a particulate, ceramic, nonresorbable bone-grafting material for augmentation of deficient alveolar ridges. A total of 207 augmentations were reported among 198 patients over 24 months. Subjective and objective data showed that durapatite alone was successful for all classes of ridges augmented; height, bulk, contour, and ridge form generally improved and soft tissue overlying the augmented ridges was firm and immobile. Impressions for dentures usually began 4 to 6 weeks after surgery and these dentures remained stable, retentive, and esthetically pleasing throughout the study. Other than transiently altered sensations resulting from mental nerve manipulation during surgery, no other important procedural complications were noted. No infection or bone resorption beneath the implant was observed throughout these studies. Durapatite used in an outpatient setting provides a less costly and more permanent method for alveolar ridge augmentation than do augmentation procedures using autogenous or banked bone.

Adult↗
PubMed1982

[Morphology of the ciliary ganglion (author's transl)].

Microscopic examination of the ciliary ganglion shows the presence of large peripheral and moderately-sized central neurones. The appearance of the intraganglionic neurones suggests that they are of the parasympathetic type, sensory fibres and sympathetic fibre bundles passing through the ganglion without synapses. Afferent fibres are long and thin and have no collateral endings, while efferent fibres are short and thick. Afferent nerve fibres have either a very thin or no myelin sheath, whereas post-ganglionic fibres are richly myelinated.

Autonomic Fibers, Postganglionic↗
PubMedDate not supplied

Soluble beta-amyloid peptides mediate vasoactivity via activation of a pro-inflammatory pathway.

Freshly solubilized beta-amyloid (Abeta) peptides display vasoactive properties, increasing both the magnitude and the duration of endothelin-1-induced vasoconstriction. We show that Abeta vasoactivity is mediated by the stimulation of a pro-inflammatory pathway involving activation of secretory phospholipase A(2) (PLA(2)), mitogen activated protein kinase (MAPK) kinase (MEK1/2), p38 MAPK, cytosolic PLA(2), and the release of arachidonic acid. Ultimately, arachidonic acid is metabolized into proinflammatory eicosanoids via the 5-lipoxygenase and cyclooxygenase-2 (COX-2) enzymes, both of which we show to be required for A beta vasoactivity. Accordingly, p38 MAPK activity is higher in the brains of transgenic mice that overproduce A beta, and COX-2 immunoreactivity is increased in the cerebrovasculature of these transgenic animals. Taken together, our data show that freshly solubilized A beta peptides can trigger a pro-inflammatory reaction in the vasculature that can be blocked by inhibiting specific target molecules, providing the basis for novel therapeutic intervention.

Amyloid beta-Peptides↗