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Biomedical subjects

D Paslin

Publications and source records attributed to D Paslin.

15 recordsLinked to original sources
PubMed1996

Androgens in the topical treatment of lichen sclerosus.

BACKGROUND: Testosterone propionate has been shown repeatedly to be effective in the treatment of vulvar lichen sclerosus, yet studies of androgens in serum of women with untreated vulvar lichen sclerosus suggested an abnormal activity of 5-alpha reductase in these patients. If impairment of 5-alpha reductase in women with untreated vulvar lichen sclerosus is a proximate cause of this disease, then dihydrotestosterone should be more effective than testosterone propionate in the treatment of the condition. METHODS: To test this hypothesis, five women with vulvar lichen sclerosus received topically either dihydrotestosterone or testosterone propionate in a double-blind cross-over study. RESULTS: These androgens appear to be equally effective in inducing objective improvement of the vulvar lichen sclerosus by both gross and microscopic criteria. CONCLUSIONS: Impairment of 5-alpha reductase may not be germane to the pathogenesis of vulvar lichen sclerosus.

3-Oxo-5-alpha-Steroid 4-Dehydrogenase↗
PubMed1991

Treatment of lichen sclerosus with topical dihydrotestosterone.

Lichen sclerosus typically affects the vulva of postmenopausal women. Because serum levels of dihydrotestosterone are low in women with vulvar lichen sclerosus and because dihydrotestosterone is an effector androgen in vulvar skin, this double-blind cross-over study assessed five women with vulvar lichen sclerosus to determine the response to treatment with dihydrotestosterone. Objective gross and microscopic improvement in lichen sclerosus accompanied sustained treatment with topical dihydrotestosterone, but not with vehicle alone. However, there was no change in symptoms (itching and dyspareunia) in these women, although dihydrotestosterone did improve some of the features of vulvar lichen sclerosus and may represent a new treatment for this disease.

Administration, Cutaneous↗
PubMed1989

Staphylococcus aureus induction of inflammatory plaques of nipples and areolae.

A 30-year-old atopic lactating woman developed a peculiar plaquelike dermatitis of nipples and areolae after infection with Staphylococcus aureus. Histologic examination showed an eosinophilic and plasma cellular edematous psoriasiform dermatitis. This constellation of findings seems distinct from other clinicopathologic states induced by staphylococci.

Adult↗
PubMed1983

Urethroid cyst.

Cysts found on the ventral surface of the penis have been pathogenetically ascribed to defective embryologic closure of the median raphe, to anomalous developmental rests of the periurethral glands of Littre, and to the ectopic development of apocrine cystadenoma in the penile skin. This case reports a previously unrecognized but compelling pathogenesis for at least some ventral penile cysts, namely the anomalous congenital outgrowth of the entodermal urethral lining, giving rise to what is here designated as a urethroid cyst.

Aged↗
PubMed1977

Chronicled metastases in a hamster melanoma.

Fortner's Melanotic Melanoma No 1 was inoculated into the right hindfoot of 86 golden hamsters. Three, 7, 14, 21, and 28 days after inoculation, groups of hamsters underwent amputations at the ipsilateral hindhip to determine when pulmonary metastases initially occur. Upon subsequent sacrifice of the hamsters, pulmonary metastases were found to occur initially within 14 days of tumor inoculation.

Amputation, Surgical↗
PubMed1977

Atopic dermatitis and impaired neutrophil chemotaxis in Job's syndrome.

A 22-year-old white woman with Job's syndrome was found to have atopic dermatitis and impaired neutrophil chemotaxis in vitro. Major clinical features of Job's syndrome included large, "cold" and recurrent staphylococcal abscesses, and intermittent bacterial and yeast infections. Evidence for atopic disease included infantile eczema progressing to flexural dermatitis, a family history of atopy, positive immediate hypersensitivity skin tests, and hyperimmunoglobulinemia E. Defective erythema responses to histamine, methyl niacinate, and methacholine (Mecholyl) chloride may explain the lack of redness, heat, or pain signalling the development of abscesses (hence the term "cold"). Impaired chemotaxis was probably due to an intrinsic neutrophil defect since patient's serum generated normal amounts of chemotactic factors and did not contain an inhibitor of neutrophil chemotaxis. A delay in neutrophil exudation in vivo may explain the abscess formations and the atopic diathesis may explain the absence of clinical signs of inflammation that have been described in this and other patients with Job's syndrome.

Adult↗
PubMed1976

Regression of a hamster melanoma with intralesional Corynebacterium granulosum.

The present study was undertaken to compare the antitumour effects of intralesionally administered Corynebacterium granulosum, Corynebacterium parvum, BCG and saline on a hamster melanoma. Forty-eight golden hamsters were inoculated subcutaneously with Forthers melanotic melanoma no. 1. Twenty-four animals bore palpable tumours which were excised. No non-excised group animal showed primary tumour regression. In the excised group, the tumours generally recurred at the excision site in the C. parvum, BCG and saline-treated animals. By contrast, the incidence of recurrence was significantly reduced by intralesional injections of C. granulosum.

Animals↗
PubMedDate not supplied

Psoriasis without neutrophils.

Histologic studies suggest that polymorphonuclear leukocytes (polys) may initiate, enable, and/or enhance the development of psoriasis. A man with long-standing psoriasis developed acute myelogenous leukemia. His psoriasis disappeared after treatment with daunorubicin and cytosine arabinoside. Smears of his peripheral blood showed essentially zero polys from day 10 to day 22 after start of chemotherapy. His psoriasis began to reappear on day 14, became prominent by day 16, and persisted. Polys may not be requisite for the development and maintenance of psoriasis.

Cytarabine↗