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Biomedical subjects

D Patakas

Publications and source records attributed to D Patakas.

42 records · Page 3Linked to original sources
PubMed1981

Left ventricular function in patients with chronic obstructive pulmonary disease.

We assessed the left ventricle function in 24 patients with severe (forced expiratory volume in 1 sec less than 50% of predicted) chronic obstructive pulmonary disease (COPD) and in 21 normal people. We measured the left ventricular systolic time intervals (STI) and echocardiographic left ventricular diameters, volumes, cardiac index, stroke volume index, echo ejection fraction and functional mean rate of circumferential fiber shortening (Vcf). In 13 of the 24 patients with COPD the mean pulmonary artery pressure and pulmonary artery wedge pressure were recorded. The STI in the patients with COPD were found abnormal while the echocardiographic parameters and pulmonary wedge pressure were normal. 1 patient had a high pulmonary arterial wedge pressure and a low Vcf. 2 patients had an ejection fraction less than 60%, but in only 1 of these the Vcf was low. No patient had all three parameters abnormal. We conclude that in patients with COPD the increased right ventricular afterload and the interaction between left and right ventricles are responsible for the abnormal left ventricular STI, while the left ventricular function is normal.

Adult↗
PubMed1981

Systolic time intervals in chronic obstructive pulmonary disease.

The systolic time intervals (STI) were used to study the left ventricular performance in 51 patients with chronic obstructive pulmonary disease (COPD), in 24 normal subjects and in 13 patients with both COPD and coronary heart disease (CHD). Our study shows that resting spine STI are abnormal in patients with COPD and that the STI in the sitting position and after exercise in these patients are changing in a similar way to those of normal subjects. In patients with both COPD and CHD we found the resting supine STI and the postexercise left ventricular ejection time index (LVETI) to differ from both normals and patients with COPD alone. When these same patients were sitting the STI failed to change, in striking contrast to the normal subjects and to the patients with COPD alone. The similar responses of normal subjects and of patients with COPD in the two stress conditions as well as the different postural and postexercise responses of patients with both COPD and CHD suggest a normal left ventricular function in patients with COPD.

Aged↗
PubMed1980

Respiratory chemosensitivity evaluated by respiratory drive and breath holding.

Ventilatory response to CO2 (delta VE/delta PCO2), respiratory drive (delta P0.1/delta PCO2), breath-holding time (BHT) on 100% O2 and log BHT/PCO2 slope during CO2 rebreathing was assessed, in 19 control subjects and in 22 patients with chronic obstructive pulmonary disease (COPD) with hypercapnia (PCO2 greater than 50 mm Hg). The log BHT/PCO2 slope was expressed as the PCO2 increment to half the BHT. We found no correlation between BHT on 100% O2 and delta VE/delta PCO2 or delta P0.1/delta PCO2 in controls and COPD subjects. delta PCO2 halving BHT had an inverse statistical significant correlation with delta VE/delta PCO2 and delta P0.1 delta PCO2 in controls and patients. In contrast to delta P0.1/delta PCO2, the delta PCO2 halving BHT increased in COPD patients and there are patients with normal respiratory drive but prolonged delta PCO2 halving BHT. The delta PCO2 halving BHT as delta VE/delta PCO2 cannot be substituted for delta P0.1/delta PCO2 in the clinical assessment of respiratory chemosensitivity in COPD patients.

Airway Obstruction↗
PubMed1980

Right ventricular echocardiographic, vectorcardiographic and electrocardiographic study in cor pulmonale.

An echocardiographic (echo), vectorcardiographic (VCG) and electrocardiographic (ECG) study of the right ventricle was carried out in 27 patients with chronic obstructive pulmonary disease and cor pulmonale. The subxiphoid echocardiographic approach was applied in all patients. The right ventricular internal diameter index (RVIDd), anterior right ventricular wall thickness (RVWT) and the ratio (R) intraventricular septum thickness/anterior right ventricular wall thickness were statistically different in the 27 patients compared to the 33 normals. All 27 patients had a RVIDd greater than 1.33 cm while in only 17 (63%, P less than 0.01) of these was right ventricular hypertrophy (RVH) detected with VCG or ECg criteria. In 20 patients the RVWT was measured and in 19 of these the RVWT was greater than 0.56 cm. In only one patient was the RVWT less than 0.56 cm. VCG or ECG criteria showed RVH in only 14 (70%) of these patients. The R was measured in 18 patients. All patients had R less than 1.99 and in only 12 (67%, P less than 0.01) of these was RVH diagnosed with VCG or ECG criteria. It seems that the RVIDd, the RVWT and the R are useful indexes for the detection of right ventricular dilatation and hypertrophy. Therefore echocardiography is superior to the conventional ECG and VCG in the recognition of right ventricular hypertrophy and dilatation.

Adult↗
PubMed1978

Respiratory drive in patients with chronic obstructive pulmonary disease.

Respiratory drive (deltaP 0.1/deltaPCO2) and ventilatory response (deltaVE/deltaPCO2) to CO2 has been estimated in 20 normal subjects and 28 patients with chronic obstructive pulmonary disease (COPD). In patients with COPD, drive and ventilatory response to CO2 were diminished, but no statistical correlation with FEV1, MBC, TLC, FRC, RV/TLC was found. A statistically negative correlation was found between blood bicarbonate and drive or ventilatory response to CO2. Patients with emphysema and normal PaCO2 demonstrated normal deltaP 0.1/deltaPCO2. In contrast, patients with chronic bronchitis with the same pulmonary function abnormalities and hypercapnia had significant diminution of the deltaP 0.1/deltaPCO2. Therefore, we feel that pulmonary function abnormalities alone cannot explain the deltaP 0.1/deltaPCO2 decrease; in most cases there sould coexist a diminished respiratory sensitivity.

Bicarbonates↗