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Biomedical subjects

D Pauleikhoff

Publications and source records attributed to D Pauleikhoff.

64 records · Page 4Linked to original sources
PubMed1990

[Drusen and their significance in age related macular degeneration].

In 81 patients with bilateral drusen and 150 patients with unilateral disciform lesions drusen were analyzed with respect to number, size, density and early and late angiographic behavior. In patients with bilateral drusen excellent symmetry was observed for all parameters. Drusen in fellow eyes of patients with avascular pigment epithelium detachments were larger, more confluent and less fluorescent than drusen in fellow eyes of patients with choroidal neovascularization. These results reveal drusen as products of specific metabolic failures of the pigment epithelium rather than unspecific aging changes. These metabolic failures result in specific individual patterns of drusen, which predispose to the development of specific complications of age-related macular degeneration.

Fluorescein Angiography↗
PubMed1989

[Long-term results of the treatment of Coats disease].

Fluorescein angiographies and clinical data of 265 patients (292 eyes) with primary retinal teleangiectasis were retrospectively evaluated. If patients showed the typical pathology of the fundus and were less than or equal to 20 years, they were summarized under the diagnosis Coats' disease (125 eyes). These patients revealed significantly more severe vascular changes and exudates compared with older patients with retinal teleangiectasis. The treated and untreated course was compared in the group of patients with Coats' disease. Coagulation treatment and in some cases additional retina detachment surgery resulted in a significantly better course of the disease in contrast to the untreated group. The degree of the pathology of the fundus was the main factor for successful therapy. If the vascular changes regressed, the situation was stabilized for the following years.

Adolescent↗
PubMed1988

[Coagulation therapy of senile macular degenerations. I. Avascular pigment epithelium detachments].

The fluorescein angiograms and visual acuity of 74 patients with avascular pigment epithelium detachment in age-related maculopathy were studied retrospectively. Thirty patients had received photocoagulation treatment, and 44 patients had been kept under observation without treatment. With regard to initial visual acuity, age, and follow-up time the two groups were statistically similar. After a mean follow-up time of four years no significant difference was found between the two groups as regards ultimate visual acuity (P = 0.9) or in the comparison between initial and ultimate visual acuity (P = 0.7). A deterioration in visual acuity was recorded in approximately two-thirds of the patients in both groups, while one-third showed improved or unchanged vision. Only in patients with an initial visual acuity better than 0.6 could this prognosis be significantly improved by coagulation therapy (p = 0.05). Higher age at onset and longer follow-up times are both unfavorable factors as regards the prognosis and cannot be influenced by photocoagulation treatment.

Aged↗
PubMed1988

[Coagulation therapy of senile macular degeneration. II. Extrafoveal choroid neovascularization].

A retrospective study was conducted covering a total of 229 patients with choroidal neovascularizations in age-related maculopathy. Of these patients, 81 had been treated by photocoagulation and 148 had been followed up without treatment. After four years' follow-up of statistically comparable groups the photocoagulation group showed significantly better results than the control group with regard to both final visual acuity (p = 0.01) as well as changes between initial and final visual acuity (p = 0.03). This therapeutic effect of photocoagulation treatment in extrafoveolar choroidal neovascularization was only observed in patients followed up for a maximum of six years (p = 007), while in patients who had been followed up for longer periods of time similar visual results between the coagulation and control groups were found (p = 0.4).

Aged↗
PubMed1987

Visual hallucinations in ophthalmology.

Forty-three patients with severe visual impairment due to bilateral eye disease were assessed for visual hallucinations, 28 of them after eye surgery. Ages ranged between 65 and 93 years and none of the patients had any psychiatric disorder. Five of the 43 patients were diagnosed as cases with Charles Bonnet syndrome reporting visual hallucinations that had developed in the course of sight deterioration. There was strong indication that sensory deprivation was an essential pathogenetic factor for this phenomenon. Three of the 28 patients assessed following eye surgery who had no history of hallucinatory phenomena experienced visual hallucinations on the 2nd postoperative day without showing any other psychiatric symptoms. The various conditions associated with visual hallucinations are discussed that may be of relevance to the ophthalmologist.

Aged↗
PubMed1987

Bone-marrow transplantation and toxoplasmic retinochoroiditis.

A 33-year-old woman underwent bone-marrow transplantation following radiation and chemotherapy for chronic myelocytic leukemia (CML); immunosuppressive therapy was continued for graft-versus-host disease. Five months after successful transplantation, she developed necrotizing retinitis in both eyes with rapid progression over the following weeks. Due to her immunosuppressed state the patient developed pneumonia and died. Postmortem evaluation of the retinal lesions in both eyes disclosed infection by Toxoplasma gondii, which was also found in the brain and myocardium. Multiple viable toxoplasmic cysts were observed at the transition zone from a necrotic to a normal retina. Additionally, cysts of Toxoplasma gondii a normal retina. Additionally, cysts of Toxoplasma gondii were seen in the adjacent intact retina and in areas of necrosis with almost complete absence of retinal or choroidal inflammation. Toxoplasmosis should therefore be considered along with fungi and viruses in the differential diagnosis of necrotizing retinochoroiditis in immunocompromised patients.

Adrenal Cortex Hormones↗
PubMed1987

[Photocoagulation in diabetic rubeosis iridis and neovascular glaucoma].

This retrospective study was performed to examine the effect of retinal coagulation on the course of iris neovascularization and neovascular glaucoma in patients with diabetic retinopathy. Sixty-four eyes in 42 patients were examined. Following retinal coagulation iris neovascularization regressed in 47 eyes (73%), while 17 eyes (27%) showed no improvement. In eyes with neovascular glaucoma, a drop in intraocular pressure was noted. Visual acuity decreased in 60% of the treated eyes. Regression of iris neovascularization was related to the number of burns applied.

Diabetic Retinopathy↗
PubMedDate not supplied

Photodynamic therapy for choroidal neovascularization in patients with multifocal choroiditis and panuveitis.

PURPOSE: To evaluate the visual benefit of photodynamic therapy (PDT) with verteporfin in patients with choroidal neovascularization (CNV) secondary to multifocal choroiditis and panuveitis over a longer follow-up period. METHODS: A total of 14 eyes of 12 patients (mean age 34 years) with a classic subfoveal CNV (13/14) or juxtafoveal CNV (1/14) were treated with PDT. Visual outcome was assessed by best-corrected visual acuity (VA). Morphologic characteristics of CNVs such as localization, size, and activity were monitored by fluorescein angiography. RESULTS: Patients were followed for 3 to 45 months (mean 23 months). During this period, one to six PDTs (mean 2.4) were performed. At the time of the first PDT no acute inflammation was seen in the affected eyes. Improved or stabilized visual function (VA loss < or = 2 lines in the Early Treatment Diabetic Retinopathy Study chart) was observed in 71.4% of the eyes. A total of 78% of the eyes showed an inactive scar in the area of CNV after PDT. Treatment failure after PDT occurred due to uninfluenced CNV growth. No further complications were observed. CONCLUSIONS: PDT in subfoveal or juxtafoveal classic CNV secondary to multifocal choroiditis and panuveitis stabilized or improved VA in the majority of patients over a longer follow-up period. No risk factor for failed VA rehabilitation could be defined.

Adolescent↗