PubMed Health⌕ Search

Biomedical subjects

D Paull

Publications and source records attributed to D Paull.

9 recordsLinked to original sources
PubMed1989

Longitudinal changes in regional cerebral blood flow in a normal elderly group.

Only one published study to date has examined longitudinal age-changes in regional cerebral blood flow (rCBF) in an elderly group. It found rCBF declined significantly in their elderly sample over a 24 to 42 month period. The current study attempts to cross-validate the earlier study's findings with an older normal elderly group and a longer time interval between rCBF studies. This study is consistent with that investigation. The normal elderly did exhibit significant declines in blood flow across a variety of indices including: gray and white matter and the Initial Slope Index. These declines were generally on the order of.50 to.75 of a standard deviation loss. No significant differences in blood flow decline between males and females were discerned. While the young-old did exhibit greater blood flow than the old-old there were no significant differences in the rate of decline between the two age-groups.

Journal Article↗
PubMed1988

Collaboration between nurse educators in Australia and New Zealand extends educational opportunities for nurses.

This paper presents a case study style report of a collaborative endeavour between nursing faculty in two institutions, one in New Zealand and the other in Australia. Expertise developed and tested in New Zealand, in teaching through the distance education mode and in the subject area of nursing theory, was able to be applied to assist with establishing a new nursing education programme in Australia. What might have been treated simply as a consultancy situation had greater mutual benefit for all those concerned because of being approached within a collaborative framework. The purpose, process, pitfalls and rewards of the association are described with the hope that others may be stimulated to seek opportunities nationally, and internationally, for pooling resources in the interests of improving the quality and availability of advanced education in nursing.

Australia↗
PubMed1987

Longitudinal neuropsychological changes in a "normal" elderly group.

The need for age-related normative data on neuropsychological measures is clearly important. This longitudinal study examines a "normal" elderly group's performance on the Luria-Nebraska Neuropsychological Battery (LNNB) across four years. This report is based on the 59 "normal" elderly volunteers seen in an earlier cross-sectional aging study (MacInnes et al., 1983). The LNNB Clinical Scales exhibited few significant changes across the four year time period. The test-retest correlations of the LNNB Clinical Scales ranged from.32 to.81. Few differences between males and females were seen. Similarly, being in an older subgroup did not affect the rate of change on the LNNB scores. Although, health status changed very little over the four years, health status at Time 2 did significantly predict 16 of the 17 LNNB Clinical Scales at Time 2. In summary, we found the LNNB accurately identified the "normal" elderly as normal. Similarly, their performance on the LNNB exhibited little meaningful change across four years.

Journal Article↗
PubMed1982

Biochemical correlates of morphologic differentiation in human breast cancer.

In 115 breast carcinoma tissues, histologica grade and cell cytosol concentrations of estrogen receptor (ER) and progesterone receptor (PR) and two breast cyst fluid proteins (gross cystic disease fluid protein [GCDFP-15] and nonreceptor progesterone-binding protein [PBP]) were deterMined. Higher levels (expressed as femtomoles per milligram of protein) of ER (128 +/- 28 versus 11 +/- 1, P less than 0.001) and PR (82 +/- 16 versus 3 +/- 1, P less than 0.001) were found in grade 1 (well-differentiated) carcinomas as compared with grade 3 (poorly differentiated) carcinomas. Similarly, higher concentrations (expressed as nanograms per milligram of cytosol protein) of GCDFP-15 (2110 +/- 840 versus 210 +/- 40, p less than 0.001) and PBP (4920 +/- 1200 versus 370 +/- 60, P less than 0.001) were found in grade 1 as compared with grade 3 carcinomas. Tumor cytosols that contained low levels of both cyst proteins (less than 225 ng/mg GCDFP-15 and less than 750 ng/mg PBP) had a high incidence of grade 3 (35 of 46, 78%) or grade 2 (15 of 46, 33%) histologic findings and had a high incidence of receptor-negative specimens (27 of 52, 52%). Based on these cutoff levels, grade 2 lesions were subdivided into a "high" cyst protein group, which had ER and PR levels similar to grade 1 tumors (93.1 +/- 26.7 for ER and 84.7 +/- 32.4 for PR, P greater than 0.3), and a "low" group, which had receptor values similar to grade 3 carcinomas (14.1 +/- 5.3 for ER and 9.1 +/- 5.2 for PR, P less than 0.3). Although the mean cytosol content of carcinoembryonic antigen (CEA) was significantly higher in malignant tissues (125 +/- 27 ng/mg cytosol protein) than in benign tissues (4.8 +/- 1 ng/mg cytosol protein), the CEA content was not significantly different between grades 1 and 3 tumors.

Apolipoproteins↗