Biomedical subjects

D Pavin

Publications and source records attributed to D Pavin.

24 records · Page 2Linked to original sources

PubMed1997

Human stress cardiomyopathy mimicking acute myocardial syndrome.

Two cases of transient acute cardiomyopathy occurring in the immediate aftermath of intense emotional stress and without any identified aetiology are described. These two cases reports, mimicking cases of acute cardiomyopathy described in patients with pheochromocytoma, suggest the possibility in man of acute catecholamine induced cardiomyopathy related to major emotional stress alone, a phenomenon so far reported only in animal experimental models.

Acute Disease↗

PubMed1997

[Accessory pathways of decremential conduction (Mahaim fibers). Treatment by endocavitary ablation; apropos of 8 cases].

Mahaim fibres are rare, right sided accessory pathways comparable with respect to certain properties (slow, decremential conduction) with "accessory atrioventricular node" located on the lateral tricuspid annulus at a distance from the Aschoff-Tawara node. Atriofascicular and atrioventricular fibres may be distinguished, both responsible for wide complex tachycardia (left bundle branch block pattern with left axis deviation). The authors report a series of 8 patients (6 women, 2 men: age: 27 +/- 11 years) without underlying cardiac disease, incapacitated by episodes of antidromic reciprocating tachycardia related to the atriofascicular fibres and justifying the indication of treatment by endocavitary ablation. In all cases, the authors tried to identify a specific potential of the Mahaim fibres on the lateral aspect of the tricuspid annulus. When the potential was recorded (7 out of the 8 cases) ablation was successful (procedure time 160 +/- 11 min; average number of applications: 9). It was not possible to identify a specific Mahaim potential in 1 case and so ablation was performed on the distal right ventricular site of insertion with no criterion of efficacy. In one woman, manipulation of the ablation catheter led to prolonged mechanical block in the Mahaim fibres, so suppressing the usual criteria of evaluation of the initial result of ablation: an early recurrence of tachycardia was observed in this case. No complications occurred during the 8 procedures. These results and those of other published cases, showed that radiofrequency ablation of Mahaim fibres is feasible with a high success rate without any immediate or long-term complications. This reliable and effective technique should form one of the therapeutic options for these invalidating junctional tachycardias.

Adolescent↗

PubMed1996

Cardiac function improvement 24 hours after isradipine SRO in patients with chronic stable angina: a double-blind randomized study.

We recently showed that Isradipine, a calcium antagonist from the dihydropyridine group, reduces ischemia and improves ventricular function at rest and during exercise, 2 hours after a single oral dose, in patients with chronic stable angina. In the present study, we evaluated the effects of long acting slow release oral (SRO) Isradipine (5 mg) compared to a placebo in 30 coronary patients with stable chronic angina, randomized in a double blind-fashion. The following parameters were obtained at rest and during submaximal exercise: left and right ventricular (LV, RV) ejection fractions (EF; %) and peak filling rate (PFR; EDV/s), assessed by gated radionuclide angiography, clinical symptoms, electrocardiograms (ECG, ST segment depression; mm), systolic and diastolic blood pressure (SBP and DBP; mm Hg). Patients were then given two oral doses of either Isradipine or placebo (one a day). The same parameters were reassessed, at rest and during n equivalent exercise, 48 hours later (24 hours after the last administration of the drug). The results after Isradipine (n = 14) showed, at rest, a significant increase in LVEF and Pfr (51 +/- 9 to 54 +/- 8 and 1.97 +/- 0.44 to 2.36 +/- 0.71, respectively) and a decrease in DBP (93 +/- 11 to 87 +/- 13); and during exercise, a significant increase in LVEF (51 +/- 11 tot 55 +/- 13) and a decrease in ST segment depression (2.3 +/- 1.9 tot 1.9 +/- 1.6). No significant change was observed after placebo in the other 16 patients. We conclude that even 24 hours after an oral administration, Isradipine SRO maintains its beneficial effects both, at rest on LV systolic and diastolic function and pressure, and during exercise on ECG signs of ischemia with improvement in LV ejection fraction.

Adult↗

PubMed1995

[Cardiac tuberculoma; value of echocardiography and therapeutic management apropos of a case].

The authors report the case of a patient with a large mass in the right ventricle which was a tuberculoma without pulmonary disease. The severity of the right ventricular obstruction required surgical intervention with quadri-antitubercular therapy. Myocardial tuberculomas are very rare and usually reported as post-mortem findings. Only four cases resulting in cure have been previously reported. Current means of investigation such as echocardiography and endomyocardial biopsy allow rapid diagnosis of these tumours and should lead to better medical management with possible surgical intervention and a higher therapeutic success rate.

Adult↗

PubMed1995

[Extrapulmonary mycobacterial infection with multiple cold abscesses].

We report one case of extrapulmonary mycobacterial infection, in the absence of HIV infection, singular by a clinical presentation simulating a tumor, associating a bulky intrahepatic mass, an abscess of the psoas, multiple intracerebral lesions, and an obstructive intracardiac mass of the right ventricle, which required a surgical resection. We comment the type of the mycobacterium involved and the hepatic and cardiac localisations, since macronodular hepatic abscesses are rare, and cardiac abcesses, exceptional.

Adult↗

PubMed1993

[Myxoma of the tricuspid valve. Apropos of a case].

The authors report the case of a chance echocardiographic finding of a tricuspid valve myxoma. Transesophageal echocardiography provided valuable complementary information concerning the precise location of the tumour. Tricuspid valve myxoma is a very rare condition: a review of the literature recensed 16 other cases. This case is of particular interest because of the associated pathological signs: erythemato-papular skin lesions which regresses after ablation of the tumour and a multinodular goitre with a cold isthmic nodule which raised the possibility of the diagnosis of Carney's complex.

Aged↗