D Pectasides — Page 5 | PubMed Health

PubMedDate not supplied

131I-labelled monoclonal antibody H17E2 in the detection of subcutaneous metastasis from gestational choriocarcinoma.

Subcutaneous metastasis is an uncommon finding in gestational choriocarcinoma. We detected such a lesion by external radioimmunoscintigraphy in a patient with gestational choriocarcinoma using 131-I labelled H17E2 monoclonal antibody raised against placental alkaline phosphatase. On the contrary, no positive image of the same metastasis was taken using 131-I labelled non-specific 11.4.1 monoclonal antibody. The successful detection of occult metastatic deposits in choriocarcinoma, which have become resistant to chemotherapy, may be of value for the potential use of curative surgery in these patients.

Adult↗

PubMedDate not supplied

Prognostic variables in greek patients with stage II breast cancer: a Hellenic Cooperative Oncology Group study.

The independent effects of several patient, tumor and treatment-related prognostic factors on relapse-free survival (RFS) and overall survival (OS) were assessed by Cox multivariate regression analysis in 988 Greek patients with stage II breast cancer. At a median follow-up time of 83 (range 3.3-131+) months and after the evaluation of all patients together, the number of positive axillary nodes (p < 0.0001), tumor size (p = 0.0024) and tumor grade (p = 0.0008) were identified as significant prognostic factors for RFS. Also, the number of positive nodes (p < 0.0001), tumor size (p = 0.0002) and ER status (p = 0.0001) were found to be significant for OS. These short-term prognostic variables are similar to those reported for this group of patients in other European countries and in the USA.

Adult↗