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D Perna

Publications and source records attributed to D Perna.

15 recordsLinked to original sources
PubMed1981

Esters of 1,7,7-trimethyl-2-exo-piperidinobicyclo[2.2.1]heptan-3-endo-ol with antiarrhythmic, local anesthetic and other activities.

A series of aliphatic and aromatic esters of 1,7,7-trimethyl-2-exo-piperidinobicyclo[2.2.1]heptan-3-endo-ol is described. A number of these compounds showed antiarrhythmic activity in guinea pigs and mice, as well as surface anesthesia in rabbits and infiltration anesthesia in mice. Circulatory, cardiac and respiratory effects in dogs are also described.

Acetylcholine↗
PubMed1980

Derivatives of 1,2,3,3-tetramethyl-2-azabicyclo[2,2,2]octan-5-trans-ol with antiarrhythmic and other activities. V.

A series of N,N-dialkyl 5-trans-carbamoyloxy-1,2,3,3-tetramethyl-2-azabicyclo [2,2,2]octanes was prepared by reaction of 1,2,3,3-tetramethyl-2-azabicyclo [2,2,2]octan-5-trans-ol with phosgene, followed by aminolysis of the resulting chlorocarbonate with aliphatic secondary amines. 5-Chloro-1,2,3,3-tetramethyl-2-azabicyclo [2,2,2] octane (cis/trans mixture) was isolated as by-product of the reaction. A number of urethanes showed antiarrhythmic activity in guinea pigs and mice, as well as surface anesthesia in rabbits and infiltration anesthesia in mice, superior or similar to lidocaine. The circulatory, cardiac and respiratory effects in dogs and hens are also described.

Anesthetics, Local↗
PubMed1970

Marihuana.

Explore the source record for details and available documents.

Cannabis↗
PubMedDate not supplied

[Sodium phosphocreatine and the cardiovascular and respiratory systems].

In the dog, rat and chick, phosphocreatine-Na has not caused, from an experimental point of view, significative modifications of the cardiovascular- and respiratory-apparatus, of the reactivity of the cardio-regulator centers, of the baroreceptorial carotid-sinus and glomus reactivity, of the gangliar-, muscarinic-, histaminergic-, dopaminergic-, beta-adrenergic- and serotoninergic- vasomotor reactivity; only the vasomotor reactivity of a constrictive-type induced by epinephrine, nor-epinephrine, occlusion of the two common carotid arteries, hypertension and by BaCl2 is moderately reduced. It is interesting to note that the hypotensive response evoked by adenosine was augmented.

Animals↗