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Biomedical subjects

D Piechocki

Publications and source records attributed to D Piechocki.

11 recordsLinked to original sources
PubMed1996

New NO-donors with antithrombotic and vasodilating activities, part 15 nitrolic acids.

Five 1-oximino-1-nitro compounds (nitrolic acids) were prepared and tested for antithrombotic and blood pressure lowering activities. 1-Nitro-ethanone 1-oxime (1, ethylnitrolic acid) 2 h after oral administration to rats inhibited thrombus formation by a laser beam in mesenteric arterioles of rats by 69% and by 46% in venules (60 mg/kg). The blood pressure of SHR rats even at this high dose only was decreased by 10% suggesting that antithrombotic and blood pressure effects can be dissociated. The in vitro decomposition of 1 at 37 degrees C nearly exclusively gave N2O and acetic acid indicating that HNO primarily had been formed.

Animals↗
PubMed1996

New NO-donors with antithrombotic and vasodilating activities, Part 14. 1,3,4-Triazol-1-oles.

Five 1,3,4-triazol-1-oles (5a-f) with different alkyl, aryl, and arylalkyl substituents in 2,5-position were synthesized and tested for their antithrombotic properties. The 2,5-dimethyl derivative 5a was most active. 2 h after administration of 60 mg/kg to rats thrombus formation by a laser beam was inhibited by 42% in arterioles and by 33% in venules. At the same dose the blood pressure of SHR rats was slightly (5%) but significantly decreased even 4 h after application of 5a. This pattern of activities suggests a nitric oxide mediated mechanism of action. 1,1'-Azo-bis-ethanone oxime(7)-the synthetic precursor of 5a-inhibited the aggregation of blood platelet (Born test) with an IC50 = 15 mumol/L.

Animals↗
PubMed1995

[Effect of Hydrochloric acid on invasion of Ascaris suum; enzyme activity in the digestive system and serum of newborn piglets].

The studies were carried out on twenty newborn piglets. They were divided into four groups. The groups no 3 and no 4 were given intragastric 0.18% HCl from the 3th day of experiment. The groups no 2 and no 4 were infected on the 7th day with 10,000 invasive eggs of Ascaris suum. The presence of A. suum larvae in the lungs and liver was examined after one week lasting invasion by Baermann method. The total acidity in the gastric content was measured. The activity of alpha-amylase, lipase and proteases was determined in the extracts from pancreas and in the contents of stomach, duodenum and jejunum. The level of pepsinogens and alpha-amylase in the animals serum was studied. The intensity of Ascaris invasion was slightly higher in the group which was given HCl than in the infected group without HCl. The activity of digestive enzymes in the both groups was similar. Only in the stomach content from the 4th group the activity of pepsin was higher (p < 0.05), and alpha-amylase and lipase were lower (p < 0.01) than in the 2nd and in the 3th group. The level of pepsinogens was always lower and alpha-amylase higher in the serum of infected animals than in uninfected groups.

Animals↗
PubMed1994

Platelet aggregation inhibiting and anticoagulant effects of oligoamines, XXIV: Interactions between oligosydnone imines and albumin or phospholipids.

Oligosydnone imines are strongly bound to albumin (alpha < 1%) in pure water. In saline, however, this effect is abolished (alpha approximately 80%). 4,4'-Propylene-bis-3-hexyl-sydnone-5-imine hydrochloride (1) moderately binds to phosphatidylcholine liposomes (PC, alpha approximately 34%). This is increased by phosphatidylethanolamine (PE). In PC/PE vesicles alpha is about 7%. The binding is further enhanced by the incorporation of negatively charged phospholipids (PL) like phosphatidylserine (PS). In PC/PE/PS liposomes complete binding of 1 can be achieved. This holds especially true if the composition of the liposomes is similar to the PL composition of platelet membranes. The results suggest that the antiplatelet activity of 1 is mediated by the bindings to negatively charged PL in the platelet membrane.

Albumins↗
PubMed1993

[Processes connected with hatching of larvae from eggs of parasitic nematodes].

Influence of such factors as temperature, pH, CO2 level and oxidation- reduction potential value in the alimentary tract of host on the stimulation of invasive eggs was studied. Changes of these factors lead to change in permeability of inner layer of egg-shell. Then the hatching fluid is released and its enzymes digest the egg-shell. In the nematodes, which have the free-living larvae, the initiation process can depend on parasite or environmental agents.

Animals↗
PubMed1991

[The influence of HCl administration on the acidity and the activity of enzymes in the stomach contents of suckling piglets].

After HCl administration to 3-21 day old crossbred piglets (wbp x pbz x złotnicka biała) the total acidity and output of acidity, the activity of pepsin, alpha-amylase and lipase were measured in the stomach content. The activity of pepsinogen was estimated in piglet's serum. The results do not indicate the significant influence of HCl on the acidity and the activity of enzymes in the stomach content.

Animals↗
PubMed1991

[The influence of HCl administration on the activity of trypsin, alpha-amylase and lipase in different parts of the alimentary tract of piglets in the first three weeks of life].

The experiments were conducted using 3 to 21 days old piglets. The content of animals stomach was supplemented with 0.18% HCl starting from the 3rd, 7th and 10th day of their life. The animals were dissected on the 4th, 7th and 11th day after HCl administration. The activity of trypsin, alpha-amylase and lipase was measured in homogenate from pancreas and duodenum and ileum contents. The presented results do not confirm the existence of significant differences between control and experimental animals.

Animals↗
PubMed1990

[Trypsin and alpha-amylase activities in the pancreas of guinea pigs. II. Effect of per os and intra-intestinal infection with invasive ova of Ascaris suum].

The guinea pigs were infected orally or intraintestinally (after laparotomy) with 5000 invasive eggs of Ascaris suum. On the 7th day after infection the invasion was controlled by lung's weight, degree of congestion, and number of larvae in the lungs. The activity of amylase was determined according to Fennel method, trypsin to Anson method. The activities of both enzymes in pancreas of orally infected animals (after laparotomy or not) were lower, and relative weight of lungs of these animals was higher than in control animals. In pancreas of guinea pig with invasive material introduced into its, the activities of amylase and trypsin were higher than in control animals, but only the activity of trypsin differed significantly.

Animals↗
PubMed1985

Swine uterus carnosinase activity in oestrous cycle and early pregnancy.

Carnosinase activity was determined in uterus extracts of sexually immature sows, on particular days of the oestrous cycle, and on the 20th and 30th day of pregnancy. In mature sows carnosinase activity in the uterus was on the average 4.5 times higher than in immature sows. Activity of the enzyme in the oestrous cycle increased from the zero day (first day of the heat) until 13th day, followed by a rapid decrease, reaching the lowest levels on the 17th day of the cycle (3 times lower on the average than on the zero day). On the last days of the cycle (20-21st) activity of carnosinase reached again levels similar to those of the zero day. Carnosinase activity in a uterus corner of pregnant sows (20th day of pregnancy) was over 4 times higher than in the "peak" day of the oestrous cycle (13th day), and over 12 times higher than in immature sows. Activity of the enzyme increased along with progressing pregnancy. It was found that activity of carnosinase in uterus corner of swines was related to the level of progesterone determined by other authors in the blood plasma.

Animals↗
PubMed1978

[Risk factors in stroke].

Risk factors were compared in 300 patients with brain stroke and 120 patients with neurosis or sciatic pains. It was found that arterial hypertension (p = 0.001) and diabetes (p = 0.01) were significantly more frequent in cases of brain stroke. Disturbances of lipid metabolism, tobacco smoking and obesity showed no significant difference. Extracerebral atherosclerosis (p = 0.001) increased the risk of stroke. Coronary arterial disease was most frequent (48.8%), myocardial infarction (8.3%) and calcifications in the aorta (32%) were second and third in frequency. Presence of at least two risk factors may be an indication to prophylactic treatment.

Aortic Diseases↗