Iopronic acid interaction with hepatic microsomal cytochrome P-450: relationship between chemical structure and binding.
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Biomedical subjects
Publications and source records attributed to D Pitré.
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A series of new heterocyclic derivatives of triiodophenyl and triiodophenoxy alkanoic acids was prepared; some of these compounds showed high billiary excretion and low acute toxicity in rats. One compound, 2-ethyl-3-[3-N-butyrolactamyl-2,4,6-triiodophenyl]-propionic acid, showed such characteristics that encouraged us to carry out further preclinical and clinical investigations.