[Some statistical and organizational aspects of the diagnosis and follow-up of urogenital tuberculosis by the antituberculosis centers].
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Biomedical subjects
Publications and source records attributed to D Plopeanu.
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In view of establishing an attitude toward patients with pathological pulmonary images, suspected of tuberculosis but without bacteriological confirmation, a study was organized in an area serviced by 9 offices of phthisiology. A total of 154 such cases were identified between 1st January and 30th April 1978. These were followed up and controlled by radiological as well as bacteriological examinations for a period of one year. The anti-tuberculous treatment did not have to be applied except when the diagnosis was confirmed as tuberculosis. In 11 of the patients (7,1%) the diagnosis was made from the start, and it was established that they had active, non-bacillary pulmonary tuberculosis. In another 49 patients (31,8%) the suspicion was abandoned, and tuberculosis. In another 49 patients (31,8%) the suspicion was abandoned, and various other pulmonary affections, but not tuberculosis, were diagnosed, either of chronic or acute type. The remaining 94 patients (61,1%) remained suspected of tuberculosis. In 16 of them, in spite of the provisions made in the protocol of the study, anti-tuberculous treatment was applied. Of them 3 died of pulmonary cancers during the follow-up. The remaining suspects were not treated. Five of them (7,3%) have developed active tuberculosis, bacteriologically confirmed in 3 of the cases. The rest had a normal eventless evolution. The authors consider the careful investigation and follow-up of suspects for a period of one year as the most correct attitude in such cases.
Analysis of epidemiological indicators is of particular importance, and relevant for assessing the efficiency of the prevention and fighting programs against tuberculosis. The most relevant epidemiometric indicators are the incidence of the infection and that of the disease itself. The annual risk of infection with tuberculous bacilli is considered as the most valuable indicator of extension or limiting tendencies of endemia, and of the efficiency of anti-tuberculosis programs. The annual incidence of the infection at the age of 14 years established by various methods, and improper conditions determined by mass allergizing of the infantile population by mandatory B.C.G. vaccination has decreased from 3,5% in 1960 to 0.8-1.0% in 1980. The level is still high, as compared with other european countries, but the rate of decrease has accelerated over the last years, a fact which demonstrates the efficiency of fighting measures applied. The incidence of contracting tuberculosis should be dealt with separately with regard to children and adults, since in children it is mainly related to primary infection, while in adults it is related to the presence of minimal lesions with phtysiogenic potential which can be traced to the post-primary stage, as well as to immuno-depressing influence of some environmental factors. In this connection the incidence of tuberculosis in children has been reduced in our country in the last 25 years from 297.2% to 10.3%. The risk of developing the disease has fallen from 1/230 in 1950 to 1/9 700 in 1980. The risk of developing the disease has decreased more rapidly in older children (between 5 and 9 years) than in the younger ones (0 to 4 years). The incidence of tuberculosis in the population aged above 15 years has fallen from 352.6% in 1955 to 70.5% in 1980. The risk of developing the disease in adults was of 1/284 in 1956 and 1/1 418 in 1980. The authors also make an analysis of the dynamics of some demographic risk factors, such as sex, age and environment.
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Tb infection prevalence and incidence are considered as the most relevant epidemiological indices which characterizes the endemic disease in a population. The study tried to establish the level of Tb infection prevalence in the age groups "6-7" and "14-15", based on the information included in the card-index for BCG pre- vaccination in the above groups, in 11 districts of Romania and the city of Bucharest. To calculate the Tb prevalence results from the BCG tests in 24,175 pupils aged 6 and 14, the persons with reactions of 10-19 mm Palmer type I-II, and reactions > or = 20 mm regardless the Palmer type were considered as infected. In 1990, infection prevalence was of 2.13% and 6.73% in pupils aged 6 and 14, respectively. The study was not intended to establish the average level of Tb infection prevalence for the whole country since it would have required adequate samples of population and working teams of the same technical level as regards skin testing and its interpretation. The obtained data allowed the calculation of the average annual rate of infection for "age-group 0-6" within the study group (0.36%). It is estimated that infection prevalence evolution can be followed up at district level, by processing the data of the card-index for pre-vaccinal tests in the pupils of the I-st and VIII-th forms.
The global incidence of tuberculosis increased during the last 5 years in the city of Bucharest by 37.8%, from 84.2%000 in 1989 to 116.0%000 in 1993. The risk of disease was permanently higher in the rural area of the Ilfov Agricultural Sector (148.5%000 in 1993). During 1993 almost 55% of new cases of pulmonary tuberculosis registered in the city of Bucharest presented advanced lesions on case-finding; 71% of these cases were tb bacilli eliminators. In the epidemiological conditions induced by a marked increase of contamination sources (periodic prevalence of tb bacilli eliminators reached 111.6%000 in 1993) the disease risk in children increased as well in Bucharest from 19.6%000 in 1989 to 38.3%000 in 1993. Tuberculosis control in Bucharest benefits from a rather complex material basis which should be improved according to the present day epidemiological conditions.
An attempt was made to make an estimation of equipment and accessibility of pneumophthisiology ambulatory units for diagnosis and treatment of patients newly discovered and the already registered ones. A number of 172 (97% of total number) pneumophthisiology units have been taken into the study showing a certain progress regarding the lb diagnosis. As for other chronic lung diseases, the specific equipment is not available in all units: 73 have not spirometer, bronchoscopy is performed in other places, a.s.o. The situation requires urgent providing the pneumophthisiology network units with new techniques equipment for diagnosis and replacing the present one which is outdated and worn-out.
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