Biomedical subjects
Publications and source records attributed to D Pollack.
Marfan's syndrome is a hereditary disorder of connective tissue, involving the ophthalmic, cardiovascular and musculoskeletal systems. Two cases are described in which protrusio acetabuli was a major problem. Otto pelvis should be considered as one of the musculoskeletal manifestations of Marfan's syndrome.
A study was conducted to determine the validity of the MMPI for 142 American Indian patients from Pacific Northwest tribes. All the MMPI profiles were similar and had significant elevations in the Sc, Pd, and Pa scales. There was no significant difference between diagnostic groups on many clinical scales. Nonpsychotic, depressed Indian patients could not be distinguished from schizophrenic patients on any clinical scale, and there were no significant differences between antisocial-alcoholic patients and those with situational reactions. There were minimal differences between the Northwest Coast, Plateau, and Plains cultural groups. The authors believe that the similarity of all subgroup profiles demonstrates a significant cultural influence on the results of the MMPI in this population of American Indians.
The purpose of this study was to provide experimental evidence for the role of Gore-Tex polytetraflourethylene as an abdominal wall prosthesis. This was achieved by evaluating tissue reaction in animals to the plastic and comparing it to that of Marlex mesh. Ten Wistar rats received especially prepared Gore-Tex implants, and another ten received Marlex. The materials were inserted in a fashion that yielded results both intraperitoneally and extraperitoneally. Gross and microscopic data were recorded at the time of sacrifice, which ranged from two to ten weeks postoperatively. Grossly, both plastics were found to be similar in intraperitoneal tissue reaction. Microscopically, all of the Gore-Tex grafts retained their original shape and demonstrated focal adherence to the muscle. In contrast, strands of Marlex showed disorganization in the host in 90 per cent of the specimens and no focal adherence to muscle. Instead, it was seen walled off in fibrous tissues. It was concluded that specifically formulated Gore-Tex may provide the more suitable abdominal wall prosthesis and that further research is necessary.
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Epidemiological studies show an increased risk of bladder cancer associated with tobacco smoking and occupational exposures. Certain carcinogens in tobacco and occupational exposures cause DNA damage and may produce specific mutations. TP53 is considered a common target for carcinogenic agents, and mutations of this gene are reported to be the most frequent nuclear abnormalities in human cancer. In order to investigate the relationship between tobacco smoking, occupations, and altered patterns of p53 expression, we have analyzed a group of 109 incident patients with superficial transitional cell carcinoma of the bladder. We assessed p53 nuclear overexpression by the use of anti-p53 antibody PAb1801 and immunohistochemistry, and identified 45 of 109 patients (41%) displaying p53-positive phenotype. We observed a significant association between the number of cigarettes smoked per day and p53 nuclear overexpression (p = 0.02). The odds ratios were 2.3 for those smoking 1-2 packs per day and 8.4 for smoking more than 2 packs per day. Similar estimates were obtained after controlling for age, sex, and race. Elevated odds ratios were also observed for dye-/ink-related (odds ratio = 2.0; 95% CI, 0.4-9.4) and cooking-related occupations (1.8, 0.6-5.0), although those were not statistically significant. These data support the hypothesis that certain carcinogens derived from cigarette smoking and occupations may induce TP53 mutations, which in turn are involved in early steps of bladder carcinogenesis.