Biomedical subjects

D Pollono

Publications and source records attributed to D Pollono.

7 recordsLinked to original sources

PubMed2000

Fetal rhabdomyomatous nephroblastoma: diagnosis by fine-needle aspiration cytology--a case report.

The present report describes the case of a 21-mo-old boy with a fetal rhabdomyomatous nephroblastoma (FRN) diagnosed by fine-needle aspiration cytology (FNAC). The smears contained numerous isolated or clustered, deeply eosinophilic, thin, elongated rhabdomyoblasts with oval nuclei. Some of these cells presented cross-striations. Peculiar clusters of small, deeply eosinophilic, round cells with and without rounded nuclei in a mosaic pattern were interpreted as representing transversally oriented rhabdomyoblasts. Fetal rhabdomyoblasts were by far the predominant type of cell. Histology of the surgical specimen proved 90% of the mass to be constituted of fetal rhadomyomatous tissue. Adequate recognition of FRN is useful for the planning of treatment.

Humans↗

PubMed1998

Pleuropulmonary blastoma: diagnosis by fine-needle aspiration cytology: a case report.

Pleuropulmonary blastoma (PPB) is an unusual pleural-based blastoma presenting in childhood composed by undifferentiated sarcomatous tissue with divergent differentiation and occasional benign epithelial-lined structures. We are presenting the cytologic features of PPB as diagnosed by fine-needle aspiration cytology (FNAC) of the lower lobe of the right lung in a 4-year-old girl. The smears showed highly malignant cells with hyperchromatic oval or multilobulated pleomorphic nuclei strongly suggesting an aggressive sarcoma. Histology of the aspirated material also revealed small fragments of a myxoid sarcoma with some pleomorphic anaplastic cells. Lobectomy and surgical pathologic investigation confirmed the diagnosis. PPB seems to be another tumor in which accurate diagnosis may be achieved by FNAC.

Biopsy, Needle↗

PubMed1997

Cytologic characteristics of peripheral neuroectodermal tumors in fine-needle aspiration smears: a retrospective study of three pediatric cases.

Cytologic diagnosis of peripheral neuroectodermal tumors (PNT) on fine-needle aspiration (FNA) smears represents a challenge to the cytopathologist. Usually ancillary studies are used to achieve definitive diagnosis. We retrospectively examined FNA material from three cases of PNT with the aim of identifying their features. Positive and negative cytologic findings were recognized. Positive features for PNT included the presence of: rather uniform appearance of the cells, which display scant but almost always-present perinuclear clear cytoplasm (suggesting a bland epithelial tumor); nuclei with distinctively smooth nuclear membrane contour, finely granular chromatin, and one or two small nucleoli (suggesting neuroendocrine anlage); and organization of the cells singly or in cohesive clusters. Negative findings included the absence of: frequent mitotic figures, large nucleoli, nuclear pleomorphism, cellular debris, histiocytes, and polymorphonuclear leucocytes. The smears appeared clean, with small, uniform cells having features suggesting a neuroendocrine epithelial tumor. These findings may prove useful for accurate cytologic diagnosis and differentiation of PNT from other small blue round cell tumours (SBRCT) of soft tissues without the use of ancillary studies since, when properly evaluated, cytomorphology of the latter group of tumors is more heterogeneous than generally believed.

Abdominal Muscles↗

PubMed1997

Malignancy-associated membranoproliferative glomerulonephritis.

An 11-year-old girl with an abdominal desmoplastic round cell tumor, treated with chemotherapy, presented with gross hematuria and proteinuria. Renal biopsy revealed type I membranoproliferative glomerulonephritis (MPGN). The association of a malignant tumor and MPGN is extremely unusual in children, and the pathogenesis of the renal lesion under these circumstances is unknown.

Abdominal Neoplasms↗

PubMed1993

Chondrosarcoma of bone as second tumor after diffuse anaplastic Wilms' tumor: diagnosis by fine-needle aspiration cytology.

A 6-yr-old boy already treated (surgery and chemotherapy) for a diffuse anaplastic Wilms' tumor discovered at the age of 10 mo, presented with a large tumor in the left femur. This proved to be a chondrosarcoma after fine-needle aspiration cytology, a diagnosis later confirmed by histology of the tumor. The patient was treated with marginal excision and prosthetic replacement but died 1 yr after this operation with lung metastasis. It is proposed that this case may represent a new association of unusual types of tumors.

Biopsy, Needle↗

PubMed1990

Incidence of childhood cancer in La Plata, Argentina, 1977-1987.

Incidence data on malignant tumors in children aged 0-14 for the period 1977-87 were calculated in La Plata, Argentina. The number of children living in La Plata was 151,085. The overall incidence of malignant tumors was 106.5 per million (127.4 for males and 83.4 for females). Leukemia (30.5%), lymphoma (15.2%) and central nervous system (14.1%) comprised 60% of all tumors. The relative frequency of histologic types was similar to the pattern recognized in other countries of Latin America and different from that reported in North America and Europe where brain tumors rank second. A high incidence of orchioblastoma (infantile embryonal carcinoma) present in this survey can only be substantiated after a longer period of study.

Adolescent↗

PubMedDate not supplied

Anaplastic Wilms' tumor. Initial diagnosis by fine needle aspiration.

The diagnosis of a diffusely anaplastic Wilms' tumor in a ten-month-old child was first suggested by cytologic and histologic study of a fine needle aspirate. The mesenchymal component was predominant (75%) and exhibited some cells with hyaline, periodic acid-Schiff-positive, intracytoplasmic droplets. Foci of clear-cell carcinoma were also present. Only one case showing this histologic pattern in this unusual variant of Wilms' tumor has been reported previously.

Anaplasia↗