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Biomedical subjects

D Poraicu

Publications and source records attributed to D Poraicu.

8 recordsLinked to original sources
PubMed1984

The efficiency of intragastric norepinephrine administration in gastrointestinal bleeding in 50 patients.

The results of the treatment of 50 patients with serious digestive tract bleeding by intragastric or intraperitoneal norepinephrine administration are reported. The doses of norepinephrine, mostly smaller than those used by Le Veen et al. who developed the method in 1972, ranged from 4 mg (42 patients) to 8 mg, given in 150 ml NaHCO3 solution, 14 g/1000 ml at 4 degrees C, in cases of intragastric administration. Although the hemorrhages and the underlying diseases were serious, 41 final and 6 temporary successes were obtained (94%), with 38 immediate and 8 late results and only 3 failures (6%), that could be explained by the anatomical situation; 17 patients died (34%), out of these only 4 because of hemorrhage (8%) that were accounted for anatomo-pathologically, as well as critically ill patients, while the other deaths occurred late, mostly due to septic shock. The efficiency in stress ulcers was remarkable. Although, in the author's opinion, the method is empirical, it has given outstandingly good results in the case of life threatening hemorrhages, with no side effects in the patients investigated.

Administration, Oral↗
PubMed1983

Decrease of red blood cell filterability seen in intensive care I. The correlation of low erythrocyte filterability with mortality and its return to normal values in critically ill patients under parenteral nutrition.

Damage to the internal viscosity of red cell is correlated with changes in the surface area to volume ratio and to prelytic phenomena. Considerable changes in shape were noticed in red cells from shocked dogs and some critically ill patients in blood smear or fresh preparation, or after in vitro treatment with colloidal plasma substitutes or glucose, and so erythrocyte filterability was investigated in critically ill patients, given or not given parenteral nutrition. The results revealed an increase of the erythrocyte filtration time (EFT 1/2) in more than 50% of the critically ill patients and less alteration in critically ill patients given total parenteral nutrition, the mortality being half as great. The return of increased EFT 1/2 to normal values occurred after 3-12 days of total parenteral nutrition in 6 patients investigated. A death rate twice as great was seen in patients with high EFT 1/2 as compared to the 27.7% mortality in patients with normal EFT 1/2, its correlation with increased filtration time being significant, r = 0.81 greater than 3 Sr, y = 1.291x + 27.44, n = 47.

Animals↗
PubMed1983

Decrease of red blood cell filterability seen in intensive care. II. Red blood cell crenelation "in vivo" as morphological evidence of increased red blood cell viscosity in low flow states.

We have reported the finding of numerous spiculed erythrocytes in blood stored for 15-21 days with acid citrate dextrose, drawing attention to the possible decrease of stored red cell deformability because of the decrease of the surface to volume ratio. The presence of anisotropy with crenated spheres, equivalent to the internal crystallization of hemoglobin, is closely related to these altered red cell parameters. The increase of erythrocyte filtration time in blood stored with acid citrate dextrose correlated well with the duration of storage up to the 21st day, r = 0.74 greater than 3 Sr, y = 1.104x + 1.853, n = 47, as well as with the increase of the proportion of crenated red cells. Using higher magnification (X700-1000) of the microcirculation in the great omentum of shocked dogs, crenated spheres could be seen within the arterioles, venules and capillaries; during refractory shock, nearly all the red cells became crenated spheres. The observation of echinocytes "in vivo" is a morphological proof of the damage to deformability of normal red blood cells in low flow states.

Animals↗
PubMed1980

Intrahematic crystallization of hemoglobin related to blood preservation with acid citrate dextrose and shock.

In 480 investigations and 40 samples of blood stored liquid with acid citrate dextrose, under adequate conditions for morphological study, many crenated cells of echinocyte types II-III were observed. In 17 samples of blood within 17-21 days of preservation 80-100% crenated red cells were observed including spherocytes. The filterability test performed with significant differences of P < 0.001. In 45 critically ill patients filterability was increased by more than 50%, P < 0.001. Some samples of stored blood appear anisotropic in polarized light microscopy, proving internal crystallization of hemoglobin, the only compound in the blood from some patients in shock and following massive transfusion of 3.5-4 liters. The phenomenon, undoubtedly could give evidence for the participation of internal crystallization of hemoglobin in the late stages of transformation of red cells into crenated shape with two possible factors being incriminated: the participation of membrane or crystallization of Hb. Anisotropic, birefringent, red cells indicate great modification in the specific viscosity of erythrocytes in above conditions. The data are in keeping with the findings of Taube, Massuda and Shoemaker (1973) who suggested that changes in the viscosity of the blood in traumatized patients may be related to alterations in the internal viscosity of the red cell.

Blood Preservation↗
PubMed1978

Parenteral nutrition in toxic septic states.

An analysis is made of two groups each of 20 patients with toxic septic states and hypercatabolic renal failure, who were given parenteral nutrition for at least 3 days. Each group was divided into two subgroups, given glucose, 13--20 and 20--27 kcal. 24 h--1 kg--1 body weight; the second subgroup was also given nitrogen-containing infusions of 0.05--0.12 or 0.12--0.17 g of N 24--1/kg--1 body weight, the total calorie intake amounting to 23--28 and 28--33 kcal. 24 h--1 kg--1 respectively, with nitrogen amounting to 150--400 kcal./g. A mean daily decrease of blood urea of 9.2 mg/100 ml was recorded, together with a positive catabolism in the series given nitrogen, and a rise of 0.8 mg/100 ml with negative catabolic index in the series fed with glucose (P less than 0.01); there were similar nitrogen losses in both the series, corrected by catabolism formula. The results demonstrated a decreased rate of catabolism in patients fed with a diet containing nitrogenous compounds.

Acute Kidney Injury↗
PubMedDate not supplied

[Decreased catabolism after toxico-septic aggression by administration of injectable amino acids].

Two comparative lots were established, of 48 and 44 patients respectively with toxico-septic syndromes, renal failure of the hypercatabolic type, that had received parenteral food for a period of between 3 and 11 days. The first group received only glucose while the second also had injectable aminoacids. In the first group was noted a daily rate of blood urea variation (r) of 1,65 mg% and a good nitrogen elimination. In the second group was noted an r of --8,13mg% (pless than 0,001) and a more rapid improvement of the clinical condition. Next to the fall in the absolute nitrogen elimination (p greater than 0,05), the nitrogen balance, computed at 36% incorporation of the administered nitrogen, was significantly improved in the second group (p greater than 0,01), demonstrating the lowering of the metabolic rate under perfusion with aminoacids.

Acute Kidney Injury↗
PubMedDate not supplied

[Intraperitoneal and intragastric administration of Norartrinal in severe digestive hemorrhages].

A total of 23 successful treatments are described, in severe haemorrhages of the upper intestinal tract, which were either primitive (ulcer, gastritis), or secondary (due to stress), in seriously ill patients, by administration of 4 g of Norartrinal intragastrically or intraperitoneally. The absence of adverse reactions, that have been looked for at anatomo-pathological investigations and during surgery, as well as the good results recorded in patients in whom the classical treatment did not result in satisfactory results, recommend this method especially in limit cases.

Adult↗