Susceptibility loci regulating total serum IgE levels, bronchial hyperresponsiveness, and clinical asthma map to chromosome 5q.
Explore the source record for details and available documents.
Asthma↗
Biomedical subjects
D Postma
Publications and source records attributed to D Postma.
Endoscopy of the airway in infants and children.
We believe that many of our readers will appreciate having some familiarity with the procedures described in this manuscript. For those who have had difficulty in deciding whether the need for diagnosis justifies the risk of a procedure, this perspective will shed new light on the problem. It is appropriate to warn our readers that complete unanimity on several points is not yet evident. For example, the indications for flexible bronchoscopy, by whom the procedure should be done, and even more specific technical aspects are questions not completely resolved. However, this article is not an effort to instruct anyone in how to do the procedure. Rather, it is an effort to acquaint our readers with progress in the field. With that in mind, we are confident that the remaining questions will be answered on the basis of the training, experience, and, ultimately, the good judgment of all the physicians involved.
Bronchoscopes↗
The nose, minor salivary glands, and sarcoidosis.
Fifty-nine patients referred to the ear, nose, and throat clinic for random minor salivary gland (MSG) biopsy were studied. After a careful head and neck examination, a random MSG biopsy and a random inferior turbinate or specific nasal lesion biopsy was done. Of 30 patients with bilateral hilar lymphadenopathy (BHL), 12 of 26 who were thought to have sarcoidosis had abnormal findings on MSG biopsy. Of 29 patients without BHL, none of the six who were later believed to have sarcoidosis had abnormal findings on MSG biopsy. The other 23 patients without BHL and who later were believed findings on MSG biopsy. A careful history, physical examination, and chest roentgenogram should precede referral for random MSG biopsy. Patients without BHL and without other evidence for systemic sarcoidosis do not benefit from random MSG biopsies. This is especially true because of the relative nonspecificity of the finding of a noncaseating granuloma.
Biopsy↗
Pyogenic otorhinologic infections in acquired immune deficiency syndrome.
A 25-year-old homosexual man with acquired immune deficiency syndrome had CNS toxoplasmosis, mucosal candidiasis, acute otitis media, and sinusitis. These problems persisted despite multiple courses of antibiotic therapy. Surgical drainage proved to be the only effective means of controlling his otorhinologic infections. We recommend early surgical intervention for this type of patient when standard antibiotic therapy for sinusitis and otitis media proves ineffective.
Acquired Immunodeficiency Syndrome↗
Polyethylene sponge total ossicular replacement prosthesis. A histopathologic study.
The histopathologic findings of a functioning high-density polyethylene sponge (Plastipore) total ossicular replacement prosthesis in a patient who died of unrelated causes are reported herein. The lack of inflammatory cell infiltration of foreign-body giant cells within, or adjacent to, the prosthesis helps substantiate the safety and efficacy of Plastipore in the reconstruction of the ossicular chain.
Adult↗