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Biomedical subjects

D Pupek-Musialik

Publications and source records attributed to D Pupek-Musialik.

At least 19 recordsLinked to original sources
PubMed1992

[Nephrotoxic effect of gentamicin on the function of the proximal tubules of the nephron and glomerular filtration].

The purpose of the study was assessment of gentamicin nephrotoxicity with reference to proximal tubule function and glomerular filtration. The study was carried out in 20 patients with nephrolithiasis and chronic pyelonephritis, and 33 patients with respiratory and bile tract infections treated with gentamicin in doses of 2-3 mg/kg/2 h. In 3 patients with nephrolithiasis and chronic pyelonephritis signs of increased nephrotoxicity of gentamicin (according to Schentag criteria) were found. Similar signs were demonstrated in 3 patients with non-urinary tract infections. The abnormalities included increased excretion of low-molecular protein and beta-2-microglobulin (B2m), reduction of B2m reabsorption and lower glomerular filtration. Beta-2-microglobulinuria increase precede by 4-5 days the fall of the glomerular filtration rate which suggests that beta-2-microglobulinuria assessment is an early sign of gentamicin neurotoxicity.

Adult↗
PubMed1990

[Nephrotoxicity of aminoglycosides].

The paper presents recent views on the aminoglycoside (AG) nephrotoxicity. The risk factors for nephrotoxicity in the patients treated with AG are discussed.

Aminoglycosides↗
PubMedDate not supplied

[Evaluation of selected indicators of the renal proximal tubule function in patients treated with gentamicin].

The study aimed at evaluating proximal renal tubule function in patients with nephrolithiasis and chronic pyelonephritis, and in patients with infectious diseases treated with gentamicin. The study involved 2 groups of patients: group A--17 patients with nephrolithiasis and chronic pyelonephritis and group B--30 patients with other infectious diseases (pneumonia, biliary tract infections) but with normal glomerular filtration rate. Patients from both groups were treated with gentamicin in a daily dose of 2-3 mg/kg for 7-10 days. Serum and urine creatinine levels were assayed in all patients prior to, 2-3, 7, 10 days, and after the treatment. Patients assigned to group B were divided into two subgroups: B1 included 15 patients with normal beta 2-microglobulinuria, and B2 15 patients with increased renal loss of beta 2-microglobulin and decreased tubular reabsorption of this protein. Significant increase in beta 2-microglobulinuria was seen on the third day of therapy, the decrease in the tubular reabsorption and glomerular filtration rate were noted in all patients on the seventh day of gentamicin administration. Beta 2-microglobulinuria was significantly higher in patients from groups A and B2 in comparison with group B1 in which no dysfunction of the proximal renal tubule was present before gentamicin therapy. A degree of beta 2-microglobulinuria is an early and sensitive indicator of gentamicin nephrotoxicity. The risk of nephrotixic symptoms is particularly obvious in patients with deteriorated function of renal proximal tubuli before the treatment with gentamicin.

Adult↗
PubMedDate not supplied

[Malignant mesothelioma of the pericardium--diagnostic problems].

A case of the malignant mesothelioma of pericardium is presented as this is rare primary neoplasm of pericardium. Diagnosis of the malignant mesothelioma of pericardium is a difficult clinical problem. The authors discuss the value of various diagnostic techniques used in diagnosis of the malignant mesothelioma of pericardium.

Female↗
PubMedDate not supplied

[Effect of nifedipine on kidney output of calcium, oxalic acid, and saturation of urinary calcium oxalate].

The study involved 30 patients treated with nifedipine in daily dose of 30 mg for 7 days. Calcium, magnesium, phosphate, oxalate, and uric acid levels in the urine were measured. It was found that nifedipine significantly decreased oxaluria urinary excretion of calcium, magnesium, phosphate, and uric acid remained unchanged following nifedipine therapy. Results may suggest that nifedipine may exert an influence on renal stone formation.

Adult↗