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D Quinones

Publications and source records attributed to D Quinones.

5 recordsLinked to original sources

Assessment of intraaxial and extraaxial brain lesions with digitized computed tomographic images versus film: ROC analysis.

RATIONALE AND OBJECTIVES: The authors evaluated the diagnostic accuracy of viewing computed tomographic (CT) scans as film versus soft-copy images at a workstation. METHODS: Receiver operating characteristic analysis of the interpretation of 202 CT scans (103 were normal, 99 were abnormal) by five neuroradiologists was performed. Abnormal images contained high- or low-attenuation intraaxial lesions or extraaxial fluid (subdural, subarachnoid, or epidural hemorrhage). Hard copies were read on a standard light box, and digital images were examined at a 1,024 x 1,250 workstation. Lesion location and type and confidence ratings were recorded on a worksheet. RESULTS: There were no statistically significant differences in diagnostic accuracy between the two display modes. Reader performance was slightly better with the workstation in the assessment of low-attenuation lesions. CONCLUSION: Diagnostic accuracy is similar for CT scans displayed at a workstation and those displayed as hard copy in the assessment of subtle intra- and extraaxial brain lesions.

Brain↗

Conservative management of rectocutaneous fistula following radical perineal prostatectomy.

Inadvertent rectal injury during radical perineal prostatectomy may sometimes lead to the development of a rectocutaneous fistula. This has traditionally been managed with diverting colostomy until closure of the fistula is assured. We report 3 cases of rectocutaneous fistula following radical perineal prostatectomy, which were managed in a more conservative fashion. This included appropriate wound care, antibiotics, bowel rest, parenteral hyperalimentation, and, in the presence of a concomitant urine leak in 1 case, optimal urinary diversion and bed rest. All fistulas healed without incident.

Aged↗

Manipulation of the immune response of mice against neu/HER2-expressing tumours.

The rat oncogene neu, and its human homologue HER2, can both cause cell transformation in vitro and tumour formation in vivo, albeit by different mechanisms. 3T3 cells (B104.1.1) transfected with mutated neu (neu) grow as solid tumours in Swiss mice. The purpose of this study was to determine whether immunization with extracts of different 3T3 lines expressing these oncoproteins would lead to a cross-reactive response, and whether this response could alter B104. 1.1 tumour growth. Both humoral and cellular cross-reactive responses were observed, which were capable of inhibiting tumour growth in vivo. This cross-reactive response may be relevant to the immunotherapy of HER2-expressing tumours in humans.

3T3 Cells↗