Biomedical subjects

D R Bassett

Publications and source records attributed to D R Bassett.

At least 19 recordsLinked to original sources

PubMed2000

Limiting factors for maximum oxygen uptake and determinants of endurance performance.

In the exercising human, maximal oxygen uptake (VO2max) is limited by the ability of the cardiorespiratory system to deliver oxygen to the exercising muscles. This is shown by three major lines of evidence: 1) when oxygen delivery is altered (by blood doping, hypoxia, or beta-blockade), VO2max changes accordingly; 2) the increase in VO2max with training results primarily from an increase in maximal cardiac output (not an increase in the a-v O2 difference); and 3) when a small muscle mass is overperfused during exercise, it has an extremely high capacity for consuming oxygen. Thus, O2 delivery, not skeletal muscle O2 extraction, is viewed as the primary limiting factor for VO2max in exercising humans. Metabolic adaptations in skeletal muscle are, however, critical for improving submaximal endurance performance. Endurance training causes an increase in mitochondrial enzyme activities, which improves performance by enhancing fat oxidation and decreasing lactic acid accumulation at a given VO2. VO2max is an important variable that sets the upper limit for endurance performance (an athlete cannot operate above 100% VO2max, for extended periods). Running economy and fractional utilization of VO2max also affect endurance performance. The speed at lactate threshold (LT) integrates all three of these variables and is the best physiological predictor of distance running performance.

Anaerobic Threshold↗

PubMed2000

Measurement of daily walking distance-questionnaire versus pedometer.

PURPOSE: This study compared measurements of daily walking distance on the College Alumnus questionnaire (CAQ) and a pedometer. METHODS: A total of 96 men and women (25-70 yr of age) with a wide range of physical activity habits were studied. Physical activity index was computed from the College Alumnus questionnaire (PAI-CAQ) as the sum of the energy expended in stair climbing, walking, and sports and recreational physical activity. Data on walking distance were compared with values obtained from the Yamax electronic pedometer (DW-500B). Participants wore the pedometer for 7 consecutive days, except when sleeping, showering, or performing sports and recreational activities. RESULTS: Subjects underestimated their daily walking distance on the CAQ, compared with the pedometer (1.43 +/- 1.01 vs 4.17 +/- 1.61 km x d(-1)). The energy expended in walking was correspondingly lower on the CAQ, compared with the pedometer-derived values (555 +/- 405 versus 1608 +/- 640 kcal x wk(-1)). CONCLUSIONS: These findings suggest that electronic pedometers are useful for examining questions about walking distance on physical activity questionnaires.

Adult↗

PubMed2000

Estimation of energy expenditure using CSA accelerometers at hip and wrist sites.

PURPOSE: This study was designed to establish prediction models that relate hip and wrist accelerometer data to energy expenditure (EE) in field and laboratory settings. We also sought to determine whether the addition of a wrist accelerometer would significantly improve the prediction of EE (METs), compared with a model that used a hip accelerometer alone. METHODS: Seventy participants completed one to six activities within the categories of yardwork, housework, family care, occupation, recreation, and conditioning, for a total of 5 to 12 participants tested per activity. EE was measured using the Cosmed K4b2 portable metabolic system. Simultaneously, two Computer Science and Applications, Inc. (CSA) accelerometers (model 7164), one worn on the wrist and one worn on the hip, recorded body movement. Correlations between EE measured by the Cosmed and the counts recorded by the CSA accelerometers were calculated, and regression equations were developed to predict EE from the CSA data. RESULTS: The wrist, hip, and combined hip and wrist regression equations accounted for 3.3%, 31.7%, and 34.3% of the variation in EE, respectively. The addition of the wrist accelerometer data to the hip accelerometer data to form a bivariate regression equation, although statistically significant (P = 0.002), resulted in only a minor improvement in prediction of EE. Cut points for 3 METs (574 hip counts), 6 METs (4945 hip counts), and 9 METs (9317 hip counts) were also established. CONCLUSION: The small amount of additional accuracy gained from the wrist accelerometer is offset by the extra time required to analyze the data and the cost of the accelerometer.

Adult↗

PubMed2000

Comparison of three methods for measuring the time spent in physical activity.

PURPOSE: Three methods for measuring time spent in daily physical activity (PA) were compared during a 21-d period among 83 adults (38 men and 45 women). METHODS: Each day, participants wore a Computer Science and Applications, Inc. (CSA) monitor and completed a 1-page, 48-item PA log that reflected time spent in household, occupational, transportation, sport, conditioning, and leisure activities. Once a week, participants also completed a telephone survey to identify the number of minutes spent each week in nonoccupational walking and in moderate intensity and hard/very hard-intensity PA. Data were analyzed using descriptive statistics and Spearman rank-order correlations. Three equations developed to compute CSA cut points for moderate and hard/very hard PA were also compared with the PA logs and PA survey. RESULTS: There was modest to good agreement for the time spent in different PA intensity categories between the three CSA cut point methods (r = 0.43-0.94, P < 0.001). Correlations between the CSA and PA logs ranged from r = 0.22 to r = 0.36, depending on the comparisons. Correlations between the survey items and PA logs were r = 0.26-0.54 (P < 0.01) for moderate and walking activities and r < 0.09 (P > 0.05) for hard/very hard activities. Correlations between the survey items and the CSA min per day varied according to the method used to compute the CSA intensity cut points. CONCLUSIONS: The results were consistent with findings from other PA validation studies that show motion sensors, PA logs, and surveys reflect PA; however, these methods do not always provide similar estimates of the time spent in resting/light, moderate, or hard/very hard PA.

Activities of Daily Living↗

PubMed2000

Evaluation of heart rate as a method for assessing moderate intensity physical activity.

UNLABELLED: To further develop our understanding of the relationship between habitual physical activity and health, research studies require a method of assessment that is objective, accurate, and noninvasive. Heart rate (HR) monitoring represents a promising tool for measurement because it is a physiological parameter that correlates well with energy expenditure (EE). However, one of the limitations of HR monitoring is that training state and individual HR characteristics can affect the HR-VO2 relationship. PURPOSE: The primary purpose of this study was to examine the relationship between HR (beats x min(-1)) and VO2 (mL x kg(-1 x -1) min(-1)) during field- and laboratory-based moderate-intensity activities. In addition, we examined the validity of estimating EE from HR after adjusting for age and fitness. This was done by expressing the data as a percent of heart rate reserve (%HRR) and percent of VO2 reserve (%VO2R). METHODS: Sixty-one adults (18-74 yr) performed physical tasks in both a laboratory and field setting. HR and VO2 were measured continuously during the 15-min tasks. Mean values over min 5-15 were used to perform linear regression analysis on HR versus VO2. HR data were then used to predict EE (METs), using age-predicted HRmax and estimated VO2max. RESULTS: The correlation between HR and VO2 was r = 0.68, with HR accounting for 47% of the variability in VO2. After adjusting for age and fitness level, HR was an accurate predictor of EE (r = 0.87, SEE = 0.76 METs). CONCLUSION: This method of analyzing HR data could allow researchers to more accurately quantify physical activity in free-living individuals.

Adult↗

PubMed2000

Validity of four motion sensors in measuring moderate intensity physical activity.

PURPOSE: This study tested the validity of four motion sensors for measuring energy expenditure (EE) during moderate intensity physical activities in field and laboratory settings. We also evaluated the accuracy of the EE values for selected moderate activities listed in the 1993 Compendium of Physical Activities. METHODS: A total of 81 participants (age 19-74 yr) completed selected tasks from six general categories: yardwork, housework, occupation, family care, conditioning, and recreation. Twelve individuals performed each of the 28 activities examined. During each activity, EE was measured using a portable metabolic measurement system. Participants also wore three accelerometers (Computer Science and Applications [CSA], Inc. model 7164; Caltrac; and Kenz Select 2) and the Yamax SW-701 electronic pedometer. For the CSA device, three previously developed regression equations were used to convert accelerometer scores to EE. RESULTS: The mean error scores (indirect calorimetry minus device) across all activities were: CSA1, 0.97 MET; CSA2, 0.47 MET, CSA3, 0.05 MET; Caltrac, 0.83 MET; Kenz, 0.96 MET; and Yamax, 1.12 MET. The correlation coefficients between indirect calorimetry and motion sensors ranged from r = 0.33 to r = 0.62. The energy cost for power mowing and sweeping/mopping was higher than that listed in the 1993 Compendium (P < 0.05), and the cost for several household and recreational activities was lower (P < 0.05). CONCLUSION: Motion sensors tended to overpredict EE during walking. However, they underpredicted the energy cost of many other activities because of an inability to detect arm movements and external work. These findings illustrate some of the limitations of using motion sensors to predict EE in field settings.

Activities of Daily Living↗

PubMed2000

Compendium of physical activities: an update of activity codes and MET intensities.

We provide an updated version of the Compendium of Physical Activities, a coding scheme that classifies specific physical activity (PA) by rate of energy expenditure. It was developed to enhance the comparability of results across studies using self-reports of PA. The Compendium coding scheme links a five-digit code that describes physical activities by major headings (e.g., occupation, transportation, etc.) and specific activities within each major heading with its intensity, defined as the ratio of work metabolic rate to a standard resting metabolic rate (MET). Energy expenditure in MET-minutes, MET-hours, kcal, or kcal per kilogram body weight can be estimated for specific activities by type or MET intensity. Additions to the Compendium were obtained from studies describing daily PA patterns of adults and studies measuring the energy cost of specific physical activities in field settings. The updated version includes two new major headings of volunteer and religious activities, extends the number of specific activities from 477 to 605, and provides updated MET intensity levels for selected activities.

Activities of Daily Living↗

PubMed2000

Validity and reliability issues in objective monitoring of physical activity.

Major technical advances have occurred within the last 10 years in the field of physical activity monitoring. The biggest one is real-time data acquisition, and the development of computer microchips that allow vast amounts of information to be stored and later recalled. It is evident that no single motion sensor will provide an accurate estimate of energy expenditure across all activities. Future directions for research include the use of combined instruments such as an accelerometer plus questionnaire, multiple motion sensors, or dual HR-motion sensor technology.

Equipment Design↗

PubMed1999

Validation of Aerosport KB1-C portable metabolic system.

The purpose of this study was to test the validity of the Aerosport KB1-C portable metabolic measurement system against the criterion Douglas bag method. During cycle ergometry, simultaneous measurements of minute ventilation (VE), oxygen consumption (VO2), and carbon dioxide production (VCO2) were made at rest and at power outputs of 50, 100, 150, 200, and 250 W. No significant differences (P > 0.05) were observed for VE, VO2, and VCO2 between the KB1-C and Douglas bag at 100, 150, and 250 W, while the KB1-C was significantly different (P < 0.05) from Douglas bag values at rest, 50, and 200 W. R values were found to be significantly different (P < 0.05) at 100, 150, and 200 W, while no significant differences were observed at rest, 50, and 250 W. The fractional concentrations of oxygen (FEO2) and carbon dioxide (FECO2) were not significantly different at 50, 100, 200, and 250 W while values at rest and 150 W were significantly different (P < 0.05). These findings show that the Aerosport KB1-C portable metabolic system is acceptable for measuring oxygen uptake in the range of 1.5 and 3.5 L x min(-1), using the medium flow pneumotach setting. At lower intensities, the low-flow pneumotach setting provides acceptable results.

Adult↗

PubMed1999

Comparing cycling world hour records, 1967-1996: modeling with empirical data.

PURPOSE: The world hour record in cycling has increased dramatically in recent years. The present study was designed to compare the performances of former/current record holders, after adjusting for differences in aerodynamic equipment and altitude. Additionally, we sought to determine the ideal elevation for future hour record attempts. METHODS: The first step was constructing a mathematical model to predict power requirements of track cycling. The model was based on empirical data from wind-tunnel tests, the relationship of body size to frontal surface area, and field power measurements using a crank dynamometer (SRM). The model agreed reasonably well with actual measurements of power output on elite cyclists. Subsequently, the effects of altitude on maximal aerobic power were estimated from published research studies of elite athletes. This information was combined with the power requirement equation to predict what each cyclist's power output would have been at sea level. This allowed us to estimate the distance that each rider could have covered using state-of-the-art equipment at sea level. According to these calculations, when racing under equivalent conditions, Rominger would be first, Boardman second, Merckx third, and Indurain fourth. In addition, about 60% of the increase in hour record distances since Bracke's record (1967) have come from advances in technology and 40% from physiological improvements. RESULTS AND CONCLUSIONS: To break the current world hour record, field measurements and the model indicate that a cyclist would have to deliver over 440 W for 1 h at sea level, or correspondingly less at altitude. The optimal elevation for future hour record attempts is predicted to be about 2500 m for acclimatized riders and 2000 m for unacclimatized riders.

Acclimatization↗

PubMed1999

Validity of the heart rate deflection point as a predictor of lactate threshold during running.

During an incremental run test, some researchers consistently observe a heart rate (HR) deflection at higher speeds, but others do not. The present study was designed to investigate whether differences in test protocols could explain the discrepancy. Additionally, we sought to determine whether the HR deflection point accurately predicts lactate threshold (LT). Eight trained runners performed four tests each: 1) a treadmill test for maximal O(2) uptake, 2) a Conconi test on a 400-m track with speeds increasing approximately 0.5 km/h every 200 m, 3) a continuous treadmill run with speeds increasing 0.5 km/h every minute, and 4) a continuous LT treadmill test in which 3-min stages were used. All subjects demonstrated an HR deflection on the track, but only one-half of the subjects showed an HR deflection on the treadmill. On the track the shortening of stages with increasing speeds contributed to a loss of linearity in the speed-HR relationship. Additionally, the HR deflection point overestimated the LT when a continuous treadmill LT protocol was used. In conclusion, the HR deflection point was not an accurate predictor of LT in the present study.

Adult↗

PubMed1998

Substrate use during and following moderate- and low-intensity exercise: implications for weight control.

Substrate utilization during and after low- and moderate-intensity exercise of similar caloric expenditure was compared. Ten active males [age: 26.9 (4.8) years; height: 181.1 (4.8) cm; Mass: 75.7 (8.8) kg; maximum O2 consumption (VO2max): 51.2 (4.8) ml x kg(-1) x min(-1)] cycled at 33% and 66% VO2max on separate days for 90 and 45 min, respectively. After exercise, subjects rested in a recumbent position for 6 h. Two h post-exercise, subjects ate a standard meal of 66% carbohydrate (CHO), 11% protein, and 23% fat. Near-continuous indirect calorimetry and measurement of urinary nitrogen excretion were used to determine substrate utilization. Total caloric expenditure was similar for the two trials; however, significantly (P < 0.05) more fat [42.4 (3.6) g versus 24.0 (12.2) g] and less CHO [142.5 (28.5) g versus 188.8 (45.2) g] was utilized as a substrate during the low-intensity compared to the moderate-intensity trial. Protein utilization was similar for the two trials. The difference in substrate use can be attributed to the exercise period because over twice as much fat was utilized during low-intensity [30.0 (11.0) g] compared to moderate-intensity exercise [13.6 (6.6) g]. Significantly more (P < 0.05) CHO was utilized during the moderate-intensity [106.0 (27.8) g] compared to the low-intensity exercise [68.7 (20.0) g]. Substrate use during the recovery period was not significantly different. We conclude that low-intensity, long-duration exercise results in a greater total fat oxidation than does moderate intensity exercise of similar caloric expenditure. Dietary-induced thermogenesis was not different for the two trials.

Adult↗

PubMed1998

Exaggerated blood pressure response to exercise: importance of resting blood pressure.

Normotensive individuals who exhibit an exaggerated blood pressure (BP) response to exercise have an increased risk of future hypertension. However, previous studies failed to control for resting BP despite the fact that an elevated resting BP in the normotensive range is also a strong predictor of future hypertension. Therefore, we determined whether maximal systolic BP is associated with resting BP. Resting BP was measured in 68 healthy normotensive men on three separate days. The subjects then performed a graded, maximal exercise test on a Monark cycle ergometer. Maximal systolic BP was strongly correlated with resting systolic BP (r = 0.64, P < 0.0001). Subjects with elevations in systolic BP during maximal exercise (> 220 mmHg) also had higher (P < 0.005) resting BP than those without (< 220 mmHg). When stepwise regression analyses were performed, systolic BP at rest was a significant independent predictor of maximal systolic BP, explaining over 40% of the variability. These results suggest that exaggerated BP response as a predictor of future hypertension reported in previous studies may be little more than a simple reflection of elevated resting BP. Specifically, these studies should not be interpreted as demonstrating that exercise BP is a better predictor of future hypertension than resting BP alone. In the future, defining the BP 'response' to exercise as a change score (i.e. maximal BP minus resting BP) may be advantageous as it permits the effects of exercise to be examined independently of the level of resting BP.

Adult↗

PubMed1997

Changes in plasma tryptophan/branched chain amino acid ratio in responses to training volume variation.

The major symptoms of overtraining including decreased exercise performance, altered mood states, and depleted muscle glycogen stores closely resemble the effects of brain serotonin, the level of which is dependent on the plasma ratio of tryptophan to branched-chain amino acids (BCAA). To examine the relation between plasma amino acids and overtraining, ten highly-trained endurance runners underwent two weeks of base training (normal training) before increasing their training volume by 40% for two weeks to achieve a state of short-term overtraining (or overreaching). The overtraining period was followed by two weeks of recovery in which training volume was reduced by 41% of the base training. For the whole group, no significant changes were observed in running economy and maximum oxygen uptake. There were no changes in resting heart rate, blood pressure, resting metabolic rate, and serum cortisol level in response to the changes in training volume. The runners experienced a significant increase (p < 0.05) in fatigue score for the profile of mood states when the training volume was increased. The elevated fatigue score returned to baseline when the training volume was reduced. Plasma free or total tryptophan, BCAA, and the tryptophan/BCAA ratio were not significantly altered throughout the course of this study. We concluded that proposed physiological markers of overtraining, including plasma tryptophan and BCAA levels, were unchanged despite a 40% increase in training volume.

Adult↗

PubMed1997

Swimming training lowers the resting blood pressure in individuals with hypertension.

BACKGROUND: Despite the fact that swimming is often recommended for the prevention and treatment of hypertension, no study has examined the potential efficacy of regular swimming exercise for lowering the blood pressure in hypertensive humans. OBJECTIVE: To test the hypothesis that regular swimming exercise lowers the resting blood pressure. DESIGN: A 10-week closely supervised swimming training program compared with a non-exercising control group. PATIENTS: Eighteen previously sedentary men and women [aged 48 +/- 2 years (mean +/- SEM)] with stage 1 or 2 essential hypertension. RESULTS: The resting heart rated, an index of cardiovascular adaptation, decreased in the swimming training group from 81 +/- 4 to 71 +/- 3 beats/min (P < 0.01). The body mass and body fat percentage did not show statistically significant changes. The systolic blood pressure of patients in the seated position fell significantly (P < 0.05) from 150 +/- 5 to 144 +/- 4 mmHg. The seated diastolic blood pressure did not change significantly. A similar magnitude of reductions in systolic blood pressure (P < 0.05) was also found in patients in the supine position. No significant changes in plasma catecholamine concentrations, casual forearm vascular resistance, plasma volume and blood volume were observed. There were no significant changes in any of these variables in the control group. CONCLUSION: Swimming training elicits significant reductions in arterial blood pressure at rest in individuals with hypertension. This is a clinically important finding since swimming can be a highly useful alternative to land-based exercises for hypertensive patients with obesity, exercise-induced asthma, or orthopedic injuries.

Blood Flow Velocity↗

PubMed1997

Maximal oxygen uptake: "classical" versus "contemporary" viewpoints.

The traditional view of VO2max owes a great deal to the work of A. V. Hill, who conducted experiments on exercising man in Manchester, England, in the 1920's. Hill and colleagues proposed that there is an upper limit to oxygen uptake (VO2max), that there are inter-individual differences in this variable, and that VO2max is limited by the circulatory and/or respiratory systems. They demonstrated that oxygen uptake increases linearly with running speed, but in some subjects it eventually "reaches a maximum beyond which no effort can drive it," a phenomenon now referred to as the VO2 plateau. In recent years, Timothy Noakes has strongly criticized Hill's concept of VO2max. He maintains that the absence of a VO2 plateau in some subjects is proof that oxygen delivery is not a limiting factor for VO2max. This view fails to recognize that the plateau is not the principal evidence for a cardiorespiratory limitation. Noakes rejects the VO2max paradigm of A. V. Hill in its entirety. The alternative paradigm he proposes is that endurance performance is limited by "muscle factors." Noakes suggests that the best distance runners have muscle characteristics that allow them to achieve higher running speeds, and since running speed is linearly related to oxygen uptake, an indirect consequence of this is that they will have higher VO2max values. This is exactly the opposite of how the relationship between VO2max and running speed at the end of a maximal exercise test should be viewed. Noakes offers little evidence to support his views, and they conflict with a vast body of scientific evidence showing that oxygen transport is a major determinant of endurance performance. After carefully reviewing the evidence on both sides of the issue, we conclude that the older "classical" VO2max paradigm of A. V. Hill is the correct one.

Cardiac Output↗

PubMed1997

Energy cost of stair climbing and descending on the college alumnus questionnaire.

In calculating the physical activity index (PAI) on the college alumnus questionnaire, it is assumed that 8 kcal are expended for every 20 steps climbed. This value is equal to an energy cost of 0.40 kcal.step-1. Since it is assumed that subjects climb and descend an equal number of stairs, the total value reflects the energy cost of stepping up (estimated at 0.30 kcal.step-1) and stepping down (estimated at 0.10 kcal.step-1). However, these values appear to be based on theoretical calculations rather than empirical observation. The purpose of this study was to quantify the energy cost of stair climbing and stair descending by measuring oxygen uptake. Twenty subjects performed continuous stair-climbing and stair-descending on an escalator at a stepping rate of 70 step.min-1. Heart rate was monitored by telemetry, and oxygen uptake was measured by the Douglas bag technique from 5 to 7 min. Results showed that the gross energy cost of stair climbing is 8.6 METs, and that of stair descending is 2.9 METs. Thus, for a 70-kg person the gross caloric costs of ascending stairs (0.15 kcal.step-1) and descending stairs (0.05 kcal.step-1) are one-half of the values previously assumed. In conclusion, the algorithm for calculating PAI on the college alumnus questionnaire should be modified to reflect a total cost of 0.20 kcal for going up and down one step. Even more precise estimates can be obtained by adjusting for body weight (going up and down one flight of stairs requires 1.63 MET.min).

Adult↗

PubMed1996

Exaggerated blood pressure response to maximal exercise in endurance-trained individuals.

Recent studies have suggested that an exaggerated blood pressure response to maximal exercise may be useful in detecting individuals who are prone to developing hypertension in later years. To examine the hypothesis that regular aerobic exercise results in a smaller blood pressure response to maximal exercise, 26 endurance-trained and 31 untrained individuals (matched on age and physical characteristics) performed graded maximal exercise tests on a cycle ergometer. Trained subjects achieved a significantly (P < .05) higher level of maximal oxygen uptake (mean +/- SE: 59.4 +/- 1.4 v 44.7 +/- 1.0 mL/kg/min), as well as a greater maximal work rate. Although there was no significant difference in resting blood pressure between the groups, endurance-trained individuals demonstrated significantly higher maximal systolic blood pressure levels compared to untrained subjects during maximal exercise (225 +/- 3 v 204 +/- 4 mm Hg). The group differences in systolic blood pressure were also significant (P < .05) at work rates of 180 W and higher. It is concluded that physically active individuals show higher blood pressure responses to maximal exercise, despite their reduced risk of future hypertension. This finding indicates that an exaggerated blood pressure response is not a valid prognostic test to indicate the likelihood of future hypertension in this population.

Adult↗