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Biomedical subjects

D R Finch

Publications and source records attributed to D R Finch.

At least 19 recordsLinked to original sources
PubMed1989

A study of the mortality from ruptured abdominal aortic aneurysms in a district community.

In a 6-year period (1982-1987), 197 cases of ruptured abdominal aortic aneurysm were identified in the area covered by the Swindon Health District. Of these, 135 (69%) reached hospital alive, 88 (45%) were operated on, and only 28 (14%) survived. This represents an overall mortality of 86%. In comparison, the mortality from elective aneurysm repair for the same period was only 3.3%. These findings suggest that early detection of aortic aneurysms, leading to elective rather than emergency repair, would be of much greater benefit than the small increase in overall survival one would expect from improving treatment in cases of rupture.

Aged↗
PubMed1986

Wound sepsis after cholecystectomy. Influence of incidental appendectomy.

We undertook a prospective study of the effect of incidental appendectomy on the safety of cholecystectomy in patients under the age of 50 years. One hundred twenty patients were randomized to have either cholecystectomy alone or cholecystectomy and appendectomy. All patients received preoperative antibiotic cover. Both groups were well matched for age, sex, obesity, and length of hospital stay. Twelve patients were withdrawn from the trial. Wound infections occurred in three of the 56 patients in the cholecystectomy group (5.3%) and in two of the 52 patients in the cholecystectomy plus appendectomy group (3.8%). Incidental appendectomy is a safe addition to elective cholecystectomy.

Adult↗
PubMed1981

In-vitro venous prostacyclin production, plasma 6-keto-prostaglandin F1 alpha concentrations, and diabetic retinopathy.

Previous studies have shown that vessels from diabetics produce less prostacyclin in vitro than those from normal controls. To determine whether this decreased production is related to complications elective biopsy of a superficial forearm vein was performed on 12 insulin-dependent male diabetics, six with nil or minimal and six with proliferative retinopathy, and seven male controls. Vein segments from the diabetics and controls produced similar amounts of prostacyclin in vitro (medians 0.11 and 0.19 ng/mg tissue respectively), but the segments from the diabetics with nil or minimal retinopathy produced less than those from the diabetics with proliferative retinopathy (medians 0.09 and 0.18 ng/mg respectively). Preoperative plasma immunoreactive concentrations of 6-keto-prostaglandin F1 alpha were not significantly different between the controls and the diabetics (medians 101 and 116 pg/ml respectively). In a separate study, however, 11 diabetics with duration of disease of over 10 years and nil or minimal retinopathy had significantly lower concentrations than a matched group of 16 with background or proliferative retinopathy (medians 79 and 121 pg/ml respectively). These results do not support an association between reduced prostacyclin production and diabetic retinopathy.

6-Ketoprostaglandin F1 alpha↗
PubMed1981

Postoperative analgesia for day-case herniorrhaphy patients. A comparison of cryoanalgesia, paravertebral blockade and oral analgesia.

Patients were admitted as day-cases for inguinal herniorrhaphy under epidural anaesthesia and chlormethiazole sedation. The patients were given oral analgesia, and in addition, some were given either a paravertebral block with a dextran/bupivacaine mixture or cryoanalgesia of the ilio-inguinal nerve for postoperative pain relief. These anaesthetic and analgesic techniques are discussed in relation to day-case herniorrhaphy.

Acetaminophen↗
PubMed1979

Wound sepsis following gastrointestinal surgery: a comparison of topical and two-dose systemic cephradine.

A prospective study of the effect of the route of administration of prophylactic antibiotic on the wound infection rate following gastrointestinal surgery was performed. Patients were randomly allocated to one of three groups: group 1 received no form of antibiotic prophylaxis; group 2 received 1 g of cephradine applied topically to the wound at closure; group 3 received 1 g of cephradine intravenously at induction of anaesthesia and a further intravenous dose of 500 mg 4 h later. Wound infections occurred in 12 of 83 patients in the control group (14.5 per cent), in 6 of the 83 patients in the group who received topical antibiotic (7.2 per cent) and in 3 of the 82 patients who received systemic antibiotics (3.6 per cent). Only the group who received systemic antibiotic showed a statistically significant reduction in the incidence of wound infections compared with the control group (P = 0.03).

Administration, Topical↗
PubMed1979

Immediate reconstruction of gunshot injuries to the face.

In the past, severe traumatic injuries to the face resulting from shotgun injuries have been managed by primary wound healing followed by little or late reconstruction. This would involve a long period of convalescence by the patient, followed by years of living with his deformity. With recent demands to minimize the patient's suffering and disabilities and to lessen hospitalization costs, a method of immediate reconstruction of such crippling facial injuries using a partially de-epithelialized skin flap has been devised and successfully applied to the patient presented here.

Adult↗
PubMed1977

Successful intra-splenic transplantation of syngeneic and allogeneic isolated pancreatic islets.

Adult rat islets harvested by the collagenase digestion/Ficoll separation technique were injected into the splenic pulp in 9 syngeneic (Lewis-leads to Lewis and WaG leads to WaG) and 13 allogeneic [(DA X Lewis) F1 leads to Lewis] experiments. Normal serum glucose levels and 24 hour urine volumes were restored in all 9 syngeneic recipients and in 11 out of the 13 allogeneic recipients in a mean of 3.3 days. Splenectomy performed on 3 of the 9 syngeneic recipients 110-178 days after transplantation resulted in a prompt return to the diabetic state. In all the remaining syngeneic recipients, normal values have persisted for the current period of observation of 6 months. In 5 untreated allogeneic recipients, rejection occurred in a mean of 5.2 days. The administration of a short course of ALS (1 ml I.P. days-1, 1, 3 and 5) to the remaining 6 animals greatly prolonged graft survival with all animals remaining normoglycaemic for at lest 4 weeks. These results were not significantly different from those recorded in comparable groups of intra-portal allogeneic islet recipients.

Animals↗
PubMed1976

The results of colostomy closure.

Complications arouse in 93 (44 per cent) of 213 patients following the closure of a temporary colostomy. These complications include 1 death, 19 faecal fistulas, 3 large bowel obstructions and 24 incisional hernias. Complications were most commonly seen following closure of colostomies of the sigmoid colon, especially when such closure was undertaken between the fourth and twelfth weeks after definite surgery. It is concluded that still greater care is needed in both the operative technique and the preoperative care of these patients.

Abdomen↗