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D R Gambino

Publications and source records attributed to D R Gambino.

3 recordsLinked to original sources
PubMed1990

Age-related changes in the neuromuscular junctions in the human posterior cricoarytenoid muscles: a quantitative study.

The posterior cricoarytenoid muscle is unique histochemically, ultrastructurally, and functionally. It has been suggested that the posterior cricoarytenoid muscle undergoes early aging. Aging in peripheral nerves has been reported to resemble a "dying back" neuropathy in that the most severe and earliest age-related changes occur at the most distal levels of the nerve fibers. The lengths and terminal axonal branching of neuromuscular junctions in 17 human posterior cricoarytenoid muscles aged 4 days to 95 years were determined. Both neuromuscular junction lengths and the numbers of axonal terminal branches in the very young group differed significantly from values in two older groups. In contrast to results reported for some other muscles, there was no significant age-related change in these parameters in the posterior cricoarytenoid muscle during adult life. This difference may be related to the repetitive contraction of the posterior cricoarytenoid muscle.

Acetylcholinesterase↗
PubMed1985

Three-dimensional computer reconstruction of the neuromuscular junction distribution in the human posterior cricoarytenoid muscle.

Recent studies have indicated that in a denervated muscle highly specific interactions occur between regenerating axons and the basal lamina of the myofiber precisely at the original synaptic sites. Since these findings suggest that synapse regeneration is facilitated at the original synaptic sites, a knowledge of the distribution of neuromuscular junctions in the human posterior cricoarytenoid (PCA) muscle may guide reinnervation procedures in this muscle. We, therefore, have used histochemical and computer graphics techniques to reconstruct the three-dimensional distribution of neuromuscular junctions in the human PCA taken fresh at autopsy. The results indicated a more localized pattern of neuromuscular junctions as compared to the human thyroarytenoid muscle. The results will be discussed with respect to their implications for procedures for reinnervation of the posterior cricoarytenoid muscle.

Computers↗