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Biomedical subjects

D R Goodless

Publications and source records attributed to D R Goodless.

8 recordsLinked to original sources
PubMed1994

Borderline tuberculoid Hansen's disease in AIDS.

We performed an immunohistochemical analysis of a skin lesion from a patient with AIDS who had borderline tuberculoid Hansen's disease. We also evaluated other laboratory features and performed peripheral blood flow cytometric analysis. The in situ immunologic response to Mycobacterium leprae was minimally affected by concomitant infection and immunosuppression by HIV. The skin demonstrated the typical characteristics of borderline tuberculoid lesions. These results indicate that although a patient with HIV infection may have laboratory evidence typical of the immunosuppression seen in AIDS, the immunologic response to M. leprae is essentially unchanged.

AIDS-Related Opportunistic Infections↗
PubMed1991

Proliferation and collagen synthesis by human dermal fibroblasts cultured from different body sites.

Distal areas in systemic sclerosis (scleroderma), such as the dorsal skin of the hand are more frequently involved and more indurated than proximal areas. On the contrary, the observation often made after surgical excision or trauma is that distal body areas heal more slowly than proximal areas. A possible explanation may be that dermal fibroblasts from distal body parts are more capable, when stimulated, to synthesize greater or lesser amounts of collagen and proliferate at different rates than dermal fibroblasts from more proximal skin. In this study, cultures of dermal fibroblasts from three different body sites (arm, forearm, and hand) of healthy volunteers were investigated for their proliferative activity and collagen synthesis after stimulation in 3% or 10% fetal bovine serum. No significant differences were observed in cell proliferation or in the relative or absolute collagen synthesis by fibroblasts cultured from the hand, forearm or upper arm. We conclude that other in vivo factors are responsible for the observed differences in fibrosis and healing at different body sites. Moreover, if clonal expansion of different fibroblast phenotypes occurs in these physiologic or disease states, it must be of a magnitude that overcomes the fundamental proliferative and biosynthetic baseline.

Adult↗
PubMed1991

Reactional states in Hansen's disease: practical aspects of emergency management.

Hansen's disease (leprosy), though not a common condition in the United States, can be found in some localities among patients who come to the emergency room for treatment. Hansen's disease (HD) is a chronic systemic infectious granulomatous disease involving principally the skin, mucosa, nerves, and eyes. The causative organism, Mycobacterium leprae, is neither highly contagious nor aggressive, but rapid alterations in the immunologic response to M leprae in affected tissues can result in acute exacerbations termed "reactions." Since most of the symptoms and morbidity in HD are a consequence of these reactional states, they must be recognized and treated early to prevent permanent sequelae, especially neurologic and ophthalmologic. Drug therapy, physical therapy, and sometimes surgery all play a role in minimizing the injury caused by reactions.

Emergency Medical Services↗
PubMed1990

Hansen's disease update.

The incidence of Hansen's disease has increased with most new cases appearing in California and Florida. The bulk of this increase can be attributed to the immigration of patients from countries where the disease is endemic. Because many immigrants from Caribbean basin countries settle in Florida, it is especially important for physicians here to be able to recognize this disease. An asymptomatic macule or patch may be the first recognizable feature. Alternatively, patients may present with an acute inflammatory episode known as a "reaction". Dapsone, rifampin, clofazimine, thalidomide and prednisone are useful in treatment. With early recognition and treatment, potentially disabling neurological and ophthalmological sequelae can be avoided. Consultation with or referral to either the Miami Regional Hansen's Disease Center or the Gillis W. Long Hansen's Disease Center in Carville, La., may be helpful.

Humans↗